Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Bereaved family members of people with dementia who received hospice reported higher perceptions of the quality of care and quality of dying.
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The observed trunk adaptations were a consistent instability factor.
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Over 40% of US NH decedents have mild-to-moderately severe or advanced dementia.
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Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous syndrome, characterized by progressive decline in behaviour or language associated with degeneration of the frontal and anterior temporal lobes.
Why it matters
This review describes frontotemporal lobar degeneration as a heterogeneous syndrome with three clinical variants and tau-positive or TDP-43-positive pathologies. It covers epidemiology, diagnosis, and management of FTLD, not Alzheimer's disease treatment, cure, or prevention.
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In this article we aim to present these recommendations and to invite professionals to consider these important issues and to contribute towards a broader discussion.
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40/100
Down syndrome (DS) is the leading cause of genetically-defined intellectual disability and congenital birth defects.
Why it matters
This review states that cognitive disabilities in Down syndrome result mainly from two processes: impaired neurogenesis and Alzheimer-like degeneration, with early onset Alzheimer disease linked to overexpression of beta-amyloid precursor protein. It describes mechanisms only and offers no treatment, cure, or prevention.
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Though both traditional and computer-based cognitive intervention programmes seem to be effective, the computer-based ones present more advantages: 1) they could individualize the programme tailored to the patient's neuropsychological pattern and needs. 2) they permit the user to make an immediate objective comparison with data collected earlier and thus help in setting up a systematic training plan by providing instant value-free feedback. 3) they offer a possibility of a widescale dissemination.
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The NH culture influences the approach to feeding in advanced cognitive impairment, whether by hand or placement of a feeding tube.
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These findings indicate that among Lewy body disease cases that pass through a mild cognitive impairment stage, any cognitive pattern or mild cognitive subtype is possible, with the attention/executive and visuospatial domains most frequently impaired.
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The authors identified 2 Class I studies, 8 Class II studies, and 30 Class III studies in ALS, but many important areas have been little studied.
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Expert manual hippocampal volumetry is more sensitive than both automated methods for the detection of hippocampal atrophy associated with mTLE.
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Medications with anticholinergic activity negatively affect the cognitive performance of older adults.
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In order to explore the impact of a degraded semantic system on the structure of language production, we analysed transcripts from autobiographical memory interviews to identify naturally-occurring speech errors by eight patients with semantic dementia (SD) and eight age-matched normal speakers.
Why it matters
This analysis of speech errors in eight patients with semantic dementia found more substitutions and omissions of words and more anomalous sentences than in controls. It concerns language production in semantic dementia, not treating, curing, or preventing Alzheimer's disease.
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Delirium was associated with increased level of S100B which could indicate cerebral damage either due to delirium or leading to delirium.
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Aging is associated with cognitive decline, yet this does not prevent older adults from finding ways to compensate for age-related deficits.
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Test-retest reliability data of the Arabic MoCA were collected approximately 35.0 +/- 17.6 days apart.
Why it matters
This study tested an Arabic version of a cognitive screening test and used it to estimate how common mild cognitive impairment is among older people in Cairo. It is about measuring and counting cases, not about treating, curing or preventing Alzheimer's disease.
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Most feeding tubes are inserted in an acute care hospital.
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After adjusting for demographics, socioeconomics, health care access and utilization, comorbidities, and service year, we found that anti-dementia medication use was approximately 30% higher among non-Hispanic Whites compared to other racial/ethnic groups (PR=0.73, 95% confidence interval [CI]=0.59, 0.91).
Why it matters
In 1,120 community-dwelling Medicare beneficiaries with dementia (2001–2003 survey data), minority beneficiaries were less likely than non-Hispanic Whites to use anti-dementia medication (prevalence ratio 0.73), even after accounting for income, health care access, other illnesses and demographics. The gap was clear for non-Hispanic Black and "other" beneficiaries but inconclusive for Hispanic beneficiaries. This shows unequal use of existing dementia drugs, not why it happens, and is not evidence about any treatment's benefit.
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High level of complex mental activity across the lifespan was correlated with a reduced rate of hippocampal atrophy.
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Cerebral ischaemia is a major cause of disability and death globally and has a profoundly negative impact on the individuals it affects, those that care for them and society as a whole.
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This study supports previous findings of heterogenous pathology in essential tremor (ET).
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40/100
The aim of the present study was to clarify the processes of decision making and end-of-life care for patients with dementia in the group homes in Japan.
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Vascular cognitive impairment (VCI) comprises a range of cognitive disorders related to cerebral vessel disease and has generally replaced the term multi-infarct dementia.
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Patients with neurologic or general conditions associated with an increased risk of falling should be asked about recent falls and further examined for the presence of specific neurologic deficits that predict falls, which include gait and balance disorders; deficits of lower extremity strength, sensation, and coordination; and cognitive impairments.
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Of 359,474 cognitively impaired residents, 49% had a diagnosis of dementia.
Why it matters
This study found that nursing home residents with cognitive impairment were less likely to be hospitalized if the facility had a dementia special care unit or higher Medicaid payment rates, and more likely to be hospitalized under a bed-hold policy. It does not test a dementia treatment or prevention, so it cannot show how to cure or prevent dementia.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Neural language networks at birth
- Delirium Reduction via Scripted Family Voice Recordings in Critically Ill Patients Receiving Mechanical Ventilation
- Association of Clinical Outcomes With Surgical Repair of Hip Fracture vs Nonsurgical Management in Nursing Home Residents With Advanced Dementia
- Brain structural alterations before mild cognitive impairment
- A Single-Channel EEG-Based Approach to Detect Mild Cognitive Impairment via Speech-Evoked Brain Responses
- Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals
- Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial
- Contribution of Socioeconomic Status at 3 Life-Course Periods to Late-Life Memory Function and Decline: Early and Late Predictors of Dementia Risk
- Relation of diabetes to mild cognitive impairment
- Lifetime risk and projected burden of dementia