Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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41/100
In adjusted analyses, walkability was not related to cognitive impairment in the full sample (OR = 0.89 (95% CI: 0.61‐1.28 for highest vs lowest quartile).
Why it matters
In the full sample, neighborhood walkability was not related to cognitive impairment. Low walkability was linked to greater likelihood of cognitive impairment only in areas with high population density, so this does not show that changing walkability would prevent cognitive impairment.
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Higher teacher‐student ratio was associated with greater gray matter volume (β = 6.25, 95% CI: 1.57, 10.92) but was not associated hippocampal volume (β = ‐0.01, 95% CI: ‐0.14, 0.11), ventricular volume (β = ‐0.04, 95% CI: ‐0.13, 0.04), or white matter hyperintensity (β = ‐0.02, 95% CI: ‐0.31, 0.26) (Table 2).
Why it matters
This study examined county-level measures of education quality and brain imaging markers in middle-aged and older adults, finding some links with gray matter and ventricular volume but not with other markers. It does not test any treatment, cure or prevention, and the findings are associations that cannot show cause and effect.
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We found declining dementia incidence but increasing dementia prevalence in a sample that includes the vast majority of older adults in the United States.
Why it matters
This study found declining dementia incidence but increasing dementia prevalence among United States Medicare beneficiaries from 2014 to 2021. The authors note implications for health system performance in providing equitable care for a growing population, but the work does not test any treatment, cure, or prevention.
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Overall, these findings highlight the generally robust, protective effect of social support on cognitive abilities in this large, diverse cohort of older adults.
Why it matters
This study examined the relationship between social support and global cognition by level of neighborhood disadvantage in the HABS-HD cohort. It found that different types of social support predicted global cognition at different levels of disadvantage, with no significant social support subscale predictors evident within ADI 4.
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Of 2 197 732 beneficiaries enrolled in D-SNPs in 2021, 881 736 (40.1%) were living in counties with aligned enrollment available and 251 305 (11.4%) enrolled.
Why it matters
This study describes availability of and enrollment in Medicare and Medicaid dual-eligible special needs plans with exclusively aligned enrollment. Beneficiaries in counties without aligned enrollment were more likely to live in rural areas and have higher area deprivation, while those enrolled in aligned plans were more likely to have dementia or Alzheimer disease.
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It is associated with various sociodemographic factors and health risks including dementia, depression, cardiovascular disease, and falls.
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With dementia incidence projected to escalate significantly within the next 25 years, the United Nations declared 2021-2030 the Decade of Healthy Ageing, emphasising cognition as a crucial element.
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There were 13,700 beneficiaries with full-year enrollment in MA (6,046) or TM (7,724), 518 with ADRD and 13,252 without ADRD.
Why it matters
This study found that telehealth services were available to and used by Medicare enrollees with Alzheimer's disease and related dementias to a similar extent compared to their non-Alzheimer's disease and related dementias counterparts. Telehealth availability during COVID-19 was negatively associated with being of Black Non-Hispanic ethnicity and living in a non-metro area.
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Environmental Burden Rank (EBR) across the sample (0.53±0.32) was near the 50th percentile nationally.
Why it matters
This study found that environmental and social vulnerabilities were elevated for minorities in a mild cognitive impairment trial, but neither environmental burden nor neighborhood deprivation predicted cognitive decline. It is a small study and does not provide evidence for treating, curing, or preventing Alzheimer's disease.
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In this study on Medicare patients with AF, Black race, low-income subsidy, and dual eligibility were found to be associated with delayed OAC initiation, suggesting potential disparities in the care of AF with timely OAC treatment.
Why it matters
This study found that among Medicare patients with atrial fibrillation, having dementia was among the factors linked to delayed start of oral anticoagulants. It is about stroke-prevention medication timing, not about treating, curing, or preventing Alzheimer's disease.
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Furthermore, we found that healthcare assistants showed no behavioural disgust avoidance on a web-based preferential looking task (equivalent to eye tracking).
Why it matters
This small study of 32 healthcare assistants in UK care homes found reduced self-reported pathogen disgust sensitivity compared with controls, which was negatively correlated with career duration. It found no behavioural disgust avoidance on a web-based looking task, and generalisation did not extend to sexual or moral disgust.
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A total of 47 adults aged 55+ years were recruited (50% male; 49% aged 60-69 years; 28% aged above 70 years), and 26 HCPs were involved, comprising dietitians (n = 8); geriatricians (n = 6); clinical therapists (n = 4); and nurses, pharmacists, catering managers and meal delivery service coordinators (n = 2 each).
Why it matters
This study gathered views from older adults and healthcare professionals in Ireland about diet and food preferences in older age, finding gaps between nutrition priorities and what older adults want. It is about dietary perspectives and does not test any treatment, cure, or prevention for Alzheimer's disease.
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14,292 patients were diagnosed with dementia over 2018–2021 (age 76.5+/−10.3 years; 53.1% female), with 96.3% linked to a census-tract-level ADI.
Why it matters
In this group of dementia patients, only 6.4% received an adequate evaluation and 30.1% received a disease-specific diagnosis. People in more disadvantaged neighborhoods were more likely to get an adequate evaluation but less likely to receive a disease-specific diagnosis.
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The overall design-oriented need referred to clear situation classifications including urgent care (fall- and wandering detection), non-urgent care (deviations in eating, drinking, sleeping), and future care (risk predictions).
Why it matters
This multimethod study identified what stakeholders need from unobtrusive monitoring technology for home-based dementia care, such as detecting falls, wandering, and changes in eating or sleeping. It is about technology design for care, not about treating, curing, or preventing Alzheimer's disease.
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41/100
This is one of the first formal studies to evaluate research attitudes among relatives of individuals with DS and shows the feasibility of using this approach to answer important questions that will guide trialists developing treatments for AD in DS.
Why it matters
This survey of 1002 families found generally favorable attitudes toward research participation, with higher favorability among those who had previously participated in research and among older respondents. It concerns willingness to enroll in clinical trials, not any treatment, cure or prevention of Alzheimer's disease.
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Dual-related differences were significantly larger than race/ethnicity differences in PAC transitions.
Why it matters
Among Medicare beneficiaries with dementia, differences in post-acute care transitions were larger between dual and non-dual patients than between racial and ethnic groups. The authors say discharge decisions should account for multiple factors at different levels.
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Dietary habits are a determining factor of the higher incidence and prevalence of chronic non-communicable diseases (NCDs).
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Fifteen articles were included: 8 focussed on the psychiatric symptoms caused by the COVID-19 infection and 7 investigated the impact of social isolation on older adults' neuropsychiatric symptoms.
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Participants included 10 physiatrists, 6 OTs, and 11 patients with mild cognitive impairment and mild dementia.
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Of the 59 residents, 57 (96⋅6%) tested positive (mean age: 82⋅8; women: 66⋅7%).
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Dementia syndrome is common and expected to increase significantly among older people and characterized by the loss of cognitive, psychological and physical functions.
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Rural patients with ADRD had 1.23 higher adjusted odds (P < .001) of going to the ED for a preventable visit compared to urban counterparts.
Why it matters
This study found that rural patients with Alzheimer's disease and related dementias had higher odds of preventable emergency department visits compared to urban patients, partly due to living in mental health professional shortage areas. It is about health care access and does not address treating, curing, or preventing the disease.
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41/100
Future experiments and validation studies Future research should determine the extent to which prevention of surgery-induced microgliosis and/or neurovascular unit dysfunction can prevent or ameliorate postoperative memory and attention deficits in animal models.
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Pericytes are unique, multi-functional mural cells localized at the abluminal side of the perivascular space in microvessels.
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Alzheimer's disease (AD) is the most common form of senile dementia, accounting for up to 70% of dementia cases.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence
- Classifying neurocognitive disorders: the DSM-5 approach
- A systematic review of the scientific evidence for the efficacy of a palliative care approach in advanced dementia
- Weight loss and metabolic improvements dominate the microbiome response in the MIND diet intervention: a randomized controlled trial
- Quality of life in dementia--a one-year follow-up study
- Evidence for improving palliative care at the end of life: a systematic review
- Physical Activity and Cognitive Decline Among Older Adults: A Systematic Review and Meta-Analysis
- Adherence to a Mediterranean Diet Protects from Cognitive Decline in the Invecchiare in Chianti Study of Aging
- Silent brain infarcts: a systematic review
- Semantic dementia: a unique clinicopathological syndrome