Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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A total of 63 studies were included in this study.
Why it matters
This review of 63 studies found that people with dementia are more likely to accept wearable devices that are aesthetically pleasing and emotionally meaningful, which may also help caregivers collect data more consistently. It concerns device design and acceptance, not any treatment, cure, or prevention for Alzheimer's disease.
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Twenty-nine individuals were enrolled, 3 were women (10.3 %), age 76.3 ± 6 years (mean ± SD).
Why it matters
In this small study of 29 people with dementia with Lewy bodies, vodobatinib was safe and well-tolerated, with reduced falls and a change in one cerebrospinal fluid biomarker compared to placebo. Exploratory clinical outcomes did not differ from placebo, and the authors state that larger trials and longer treatment periods are needed.
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Brain functional connectivity alterations, that is, pathological changes in the signal exchange between areas of the brain, are occurring in several neurological diseases, including neurodegenerative and neuropsychiatric ones.
Why it matters
This study proposes a formal and computational representation of brain states, using paths between connectome configurations to model disease progression, with references to Alzheimer-Perusini's disease among other conditions. It is a conceptual and computational framework and does not report any treatment, cure, or prevention.
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BackgroundCurrent physical activity literature does not distinguish between young (dementia diagnosed before 65) and late onset dementia despite differences between these groups such as age, being known to influence physical activity levels.
Why it matters
This cross-sectional study found no significant differences in physical activity between people with young onset dementia and age-matched controls without dementia. People with late onset dementia did less light activity and spent more time sedentary and sleeping than controls, but the study cannot show whether activity levels affect dementia risk.
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Spousal caregivers of persons living with dementia (PLwD) often experience high overload and loneliness due to the intensive and ongoing nature of caregiving for their partner.
Why it matters
Among 61 spousal caregivers in rural Appalachia, husbands reported lower loneliness and overload than wives, while overall use of paid services was similar. Greater emotional strain and worse functional impairment in the person with dementia were linked to more paid service use.
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84 (4.8%) had NGT procedure flags. Of these 84, 28 (33%) died during admission.
Why it matters
In this audit, 33% of people with a nasogastric tube flag died during admission and 47.6% were deceased within six months, and the authors say these insertions have a high likelihood of being considered 'non-beneficial'. This concerns end-of-life tube feeding decisions, not treating or preventing Alzheimer's disease.
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= 126). Subgroup analyses revealed stronger associations in LMICs than in high-income countries.
Why it matters
This ecological analysis found that delayed age at first childbirth is associated with higher female dementia prevalence and sex disparities, particularly in low- and middle-income countries. It does not test any treatment or cure, and the authors call for individual-level longitudinal studies to explore potential causal pathways.
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Interprofessional case conferences may lead to more awareness regarding gaps in primary palliative care, one's own care routines or a lack of psychosocial support.
Why it matters
This qualitative study found that after interprofessional case conferences, general practitioners followed three different strategies, some maintaining their usual routines and others changing them. It concerns cooperation in palliative care for non-cancer patients, not treating or preventing Alzheimer's disease.
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According to the II level neuropsychological evaluation, 4.8 % of MSA patients met criteria for dementia and 53,2 % for MCI.
Why it matters
This study found that the MMSE and MoCA are effective tools to detect mild cognitive impairment and dementia in patients with multiple system atrophy, with specific cutoff scores identified for each condition. The MoCA fluency item emerged as a reliable tool to detect mild cognitive impairment.
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Traditional dementia-prevention programs have limited accessibility and lack continuous monitoring, making sustained cognitive and emotional support challenging.
Why it matters
In 80 community-dwelling people with dementia, twice-weekly AI care calls were followed by significantly lower depression scores and significantly higher memory scores. This is a small before-and-after study of a support intervention, not evidence that Alzheimer's disease can be cured or prevented.
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Diabetic-related cognitive dysfunction, especially mild cognitive impairment (MCI), is a serious complication of type 2 diabetes mellitus (T2DM).
Why it matters
This review discusses mechanisms, models, and potential treatments for cognitive dysfunction in type 2 diabetes, including antidiabetic drugs such as sulfonylureas, biguanides, insulin, GLP-1 receptor agonists, and SGLT2 inhibitors. It highlights gaps in knowledge and challenges in translating organoid models to clinical practice, so it does not establish that any treatment prevents or cures Alzheimer's disease.
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Black Americans a have higher risk of cognitive impairment relative to other racial/ethnic groups, and Black women have the highest prevalence of Alzheimer's disease and related dementias; however, the mechanisms underlying cognitive impairment are poorly understood.
Why it matters
In this group of Black women, greater neighborhood disadvantage was linked to more cognitive concerns only before accounting for education, and the link disappeared after adjusting for education. This means neighborhood disadvantage as measured here was not associated with increased cognitive concerns once education was considered.
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The study determined an adequate sample size (KMO = 0.67), with sufficient item correlations for factor analysis (χ2 = 449.74; p < 0.001).
Why it matters
This study validated a Turkish version of the MIND diet adherence scale for use in young adults. It is a measurement tool validation and provides no evidence about treating, curing, or preventing Alzheimer's disease.
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Informal caregivers of patients with neurodegenerative diseases are confronted with significant psychological distress.
Why it matters
In this cross-sectional study, dementia caregivers had higher total empathy and depression scores than stroke caregivers and non-caregivers, while stroke caregivers reported greater perceived stress. Cognitive empathy and positive affective empathy were linked to less psychological distress, but the design cannot show cause and effect.
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Dementia is a growing challenge in Southeastern and Western Europe, with aging trends projected to accelerate in the former region.
Why it matters
This perspective article describes regional gaps in dementia care in Southeastern Europe and presents strategies such as mobile memory teams, a Circle of Care Hub framework, and piloted digital tools to improve coordination and support. These are care-delivery approaches rather than treatments, cures, or prevention, and the article notes barriers such as limited services and workforce shortages.
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The results of the data analysis revealed two main categories: emotional schemas in mild cognitive impairment and understanding the meaning of the diagnosis.
Why it matters
This qualitative study explored the emotional experiences and meaning-making of adults with mild cognitive impairment, finding that their experience involves more than just cognitive problems. A deeper understanding could improve interventions and quality of life, but no treatment or cure is tested.
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Cognitive training, whether combined with active or sham tDCS, led to significantly increased fractional anisotropy averaged across all brain regions, indicating an overall improvement in white matter integrity.
Why it matters
This pilot study found that cognitive training improved white matter integrity, but transcranial direct current stimulation provided no additional benefit. It does not show that this combined treatment cures, treats or prevents Alzheimer's disease.
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The observation group had significantly higher blood uric acid levels than the control group (P<0.05).
Why it matters
In patients with acute cerebral infarction and H-type hypertension, higher blood uric acid levels were linked to more severe dementia and worse prognosis, and uric acid was identified as an independent risk factor for prognosis. This highlights the importance of monitoring uric acid in these patients, but it does not show that lowering uric acid treats or prevents dementia.
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Data point to cultural, socioeconomic and systemic barriers to accessing quality EOL care for PLWD.
Why it matters
This qualitative study reports that people from minority ethnic and socioeconomically disadvantaged groups describe poor experiences of end-of-life dementia care, with cultural, socioeconomic, and systemic barriers including fear, stigma, mistrust, and financial concerns. The authors call for co-produced, culturally sensitive interventions to address these inequalities, but no treatment, cure, or prevention was tested.
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The findings revealed three core areas: (a) types of digital tools used, including online platforms, video conferencing, mobile applications and SMS services; (b) educational domains addressed, such as knowledge and skills, psychological support, communication and social interaction, and environmental and technological adaptation; and (c) implementation strategies and outcomes, highlighting personalisation, cultural sensitivity and technological adaptability, which improved knowledge, emotional well-being and carer self-efficacy.
Why it matters
This scoping review found that digital tools such as online platforms, video conferencing, apps, and SMS can improve knowledge, emotional well-being, and self-efficacy for informal dementia carers, and it proposes a progressive framework for their use. It concerns carer education and support, not treating, curing, or preventing Alzheimer's disease.
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Farming communities experience significant rates of dementia, however research exploring the support needs of this population is scarce.
Why it matters
This scoping review found a large research gap on the experiences of dementia in farming communities, with unique challenges and opportunities for fostering resilience. It does not test a treatment or cure for Alzheimer's disease.
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Assistive technologies hold significant potential to enhance the quality of life for persons with dementia and their caregivers by addressing key concerns related to safety, independence, and social inclusion.
Why it matters
This overview of reviews categorized ethical issues with assistive technologies for people with dementia and their caregivers, including autonomy, privacy, equity, surveillance, depersonalization, and stigmatization. It addresses ethical concerns about technologies and does not test any treatment, cure, or prevention for Alzheimer's disease.
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The findings support Istanbul's resilience and offer valuable guidance for urban planning and disaster management, both locally and globally.
Why it matters
This study assessed disaster vulnerability across Istanbul's districts and proposed a risk reduction framework. It contains no information relevant to Alzheimer's disease.
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Public health messaging is an ethically fraught exercise.
Why it matters
This paper discusses the ethics of allocating responsibility for dementia prevention in public health messaging. It argues that dementia campaigns can promote equity and health but can also reinforce stigma or blame affected populations, so messaging needs careful ethical consideration.
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Most factors of the MoCA-B were significantly different between the two groups, and the PSCN group completed the MoCA-B faster (p 0.05).
Why it matters
This study found that the Montreal Cognitive Assessment Basic Scale had greater sensitivity and negative predictive value than the Mini-Mental State Examination for post-stroke cognitive impairment. It is about improving screening for cognitive impairment after stroke, not about treating, curing, or preventing Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Understanding the factors associated with patients with dementia achieving their preferred place of death: a retrospective cohort study
- Associations between U.S. county‐level social infrastructure and dementia among Medicare beneficiaries, 2020
- Medicare program expenditures associated with hospice use
- Palliative Access Through Care at Home: experiences with an urban, geriatric home palliative care program
- Hypertension and aging
- Seven sirtuins for seven deadly diseases of aging
- Precision Nutrition for Dementia: Exploring the Potential in Mitigating Dementia Progression
- Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
- Systematic detection and multidisciplinary care of delirium in older medical inpatients: a randomized trial
- Executive dysfunction and long-term outcomes of geriatric depression