Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The study included 13,431 individuals diagnosed with dementia at UVA (n = 7,152) and Carillion Clinic (n = 6,279).
Why it matters
This study found that most patients diagnosed with dementia did not receive an adequate evaluation or a specific diagnosis, and that the likelihood of a specific diagnosis varied with neighborhood deprivation in a U-shaped pattern. It is about diagnostic practices, not about treating, curing, or preventing Alzheimer's disease.
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Policy implementation was associated with a significant decrease in patient out-of-pocket cost.
Why it matters
This study found that a national dementia policy in Korea was associated with a significant decrease in patient out-of-pocket cost, but no statistically significant changes in total mean healthcare cost. It concluded that national policies need to be monitored to reduce the economic burden of patients with dementia while maintaining the financial sustainability of the healthcare system.
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This study highlights diverse links between dementia mortality and demographic and socioeconomic factors at the county level in the United States.
Why it matters
This county-level analysis found that dementia mortality rates varied geographically, with clusters of high rates in the South, Midwest, and Maine, and that county median income had a significant negative effect on dementia mortality. The study is about spatial patterns and demographic and socioeconomic associations with dementia mortality, not about treating, curing, or preventing Alzheimer's disease.
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Our results suggest that the relationship between greater neighborhood disadvantage and poorer cognitive function are very subtle and may only be present for some, but not all, cognitive domains.
Why it matters
In 852 mostly White, mostly female cognitively normal adults, this study examined whether neighborhood disadvantage was linked to lower cognitive function after controlling for age, education, and sex. The abstract does not report whether the hypothesis was supported.
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The study population of 99,774 individuals had a mean age of 71.0 years and was 49.1% female, 73.9% White, and 17.8% Black, with 62.0% living in an urban setting.
Why it matters
This study found that not achieving CMS Star Medication Adherence quality measures for diabetes, hypertension, and hyperlipidemia therapies was associated with increased risk of cognitive decline outcomes. The odds of cognitive decline increased as more adherence measures were missed.
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Over 78 million people will suffer from dementia by 2030, emphasizing the need for early identification of patients with mild cognitive impairment (MCI) at risk, and personalized clinical evaluation steps to diagnose potentially reversible causes.
Why it matters
This study used machine learning on electronic health records to try to predict mild cognitive impairment up to a year before it was diagnosed, achieving a prediction accuracy (ROC-AUC) of 68.2±0.7. It also produced a data-driven list of clinical procedures commonly ordered during MCI workups, which could help guide clinical guidelines and order sets.
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The term neuronutrition has been proposed as part of nutritional neuroscience, studying the effects of various dietary components on behavior and cognition.
Why it matters
This review discusses how nutrition may affect brain health through mechanisms like inflammation, oxidative stress, and the gut-brain axis, and suggests a personalized approach is needed. It is a narrative review of existing ideas and does not provide evidence that any specific diet prevents or treats Alzheimer's disease.
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Blood pressure is not a static parameter, but rather undergoes continuous fluctuations over time, as a result of the interaction between environmental and behavioural factors on one side and intrinsic cardiovascular regulatory mechanisms on the other side.
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Early detection of age-related cognitive decline has transformative potential to advance the scientific understanding of cognitive impairments and possible treatments by identifying relevant participants for clinical trials.
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40/100
The findings of this study highlight the importance of accurate mortality data for studying and addressing population health trends.
Why it matters
This analysis of 15 years of US death certificate data found that when Down syndrome was reported as the underlying cause of death, Alzheimer's disease and dementia deaths were hidden; after amending those certificates, Alzheimer's disease and dementia became the leading cause of death among adults with Down syndrome. The findings concern how deaths are recorded and counted, not how Alzheimer's disease is treated or prevented.
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The worldwide burden of dementia is immense, and set to increase to unprecedented levels in the coming decades, due to population aging.
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Our findings suggest neighborhood deprivation is an important risk factor of mortality among older adults with ADRD while accounting for individuals’ demographic and clinical characteristics.
Why it matters
This study found that neighborhood deprivation was associated with higher mortality risk among older adults diagnosed with Alzheimer's disease and related dementias. The authors call for intervention and policy programs to address these social factors, but the work does not test any treatment, cure, or prevention for the disease.
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Frailty syndrome, sarcopenia and cognitive decline are associated with reduced faecal microbiota biodiversity, reduced abundance of bacteria able to synthetize short-chain fatty acids (SCFA), including Faecalibacterium prausnitzii , and reduced faecal butyrate levels.
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Cognitive training is a promising tool for slowing or preventing cognitive decline in older adults at-risk for dementia.
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Adequate adherence is a necessary condition for success with any intervention, including for computerized cognitive training designed to mitigate age-related cognitive decline.
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The Medicare hospice benefit was originally designed around a cancer disease paradigm but increasingly serves people living with dementia.
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Dementia, with a high incidence rate, fast-developing syndrome and large disease burden, raises challenges to global health and social systems.
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40/100
Over half of participants (54%) received SFU as initial second-line ADM, 14% received BI, and 32% received another ADM.
Why it matters
This study examined which second-line diabetes medications older adults with type 2 diabetes started and found that medications requiring caution in frail patients were still commonly used. It provides no information about treating, curing, or preventing Alzheimer's disease.
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This manuscript examines the research questions being addressed in prevention research by characterizing the distribution and trends of study designs included in primary and secondary prevention research supported by the National Institutes of Health through grants and cooperative agreements, together with the types of prevention research, populations, rationales, exposures, and outcomes associated with each type of design.
Why it matters
This analysis of NIH prevention research funding found that observational studies and analyses of existing data dominated, while intervention studies were far less common. It describes the research portfolio and reports no findings about treating, curing, or preventing Alzheimer's disease.
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Peri-operative neurocognitive disorders are the most common complication experienced by older individuals undergoing anaesthesia and surgery.
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Neighborhood characteristics may play an influential role in SCD regardless of race/ethnicity and thus are likely important risk factors for AD/ADRD.
Why it matters
In 313 older adults with normal cognition in New York City, neighborhood deprivation predicted subjective cognitive decline even when race and ethnicity were accounted for. This suggests neighborhood conditions may matter independently, but the study was cross-sectional and cannot show cause and effect.
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Nearly 30-50% of people living with HIV experience HIV-Associated Neurocognitive Disorder (HAND).
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Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD).
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Prevalence of dementia continues to increase because of the aging population and limited treatment options.
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BC residual was significantly associated with worse cognitive performance.
Why it matters
This conference abstract reports that black carbon residual was significantly associated with worse cognitive performance, with the association modified by sex, history of solvent exposure and depression. It found stronger effects in females, persons with history of solvent exposure, or depression.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba
- Antihypertensive drug classes and risk of incident dementia: a multinational population-based cohort study
- Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study
- Covid-19 and Aging: Challenges and Opportunities
- A 5-year longitudinal study of the Mini-Mental State Examination in normal aging
- Racial/ethnic disparities in medication use among veterans with hypertension and dementia: a national cohort study
- Long-Term Care Workforce Issues: Practice Principles for Quality Dementia Care
- Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients
- Use of Speech Analyses within a Mobile Application for the Assessment of Cognitive Impairment in Elderly People
- The role of frailty and comorbidities in severe infections and the risk of dementia: a prospective, multicohort, observational study