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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial

    ✓ Peer-reviewed alzhub usefulness score 88 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024-04-17 Clinical trials

    Forty-four participants were recruited between September 2019 and June 2022.

  2. Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Alzheimer's research & therapy 2024-10-02 Drug development

    EQW affected FCN2 (Cohen's d -0.019), PAI-1 (Cohen's d -0.033), sVCAM-1 (Cohen's d 0.035) and a cytokine-cytokine cluster (Cohen's d 0.037) significantly compared with placebo.

  3. Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Nature communications 2023-12-12 Treatments

    We report the case of a 79-year-old woman with Alzheimer's disease who participated in a Phase III randomized controlled trial called CLARITY-AD testing the experimental drug lecanemab.

  4. IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer's disease: Systematic Review and Meta-Analysis

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. Scientific reports 2018-08-13 Risk factors

    We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer's disease.

  5. Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Redox biology 2023-09-07 Drug development

    Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder and the most common cause of cognitive decline.

  6. Peripherin is a biomarker of axonal damage in peripheral nervous system disease

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Brain : a journal of neurology 2023-11-01 Biomarkers

    We demonstrated that peripherin is distributed in sciatic nerve, and to a lesser extent spinal cord tissue lysates, but not in brain or extra-neural tissues.

  7. Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Trends in neurosciences 2020-10-27 Genetics

    Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease.

  8. A meta-analysis of cytokines in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Biological psychiatry 2010-08-08 Tau biomarkers

    These results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β, IL-12 and IL-18 and higher CSF concentrations of TGF-β.

  9. Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality: A Population-Based Study

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Annals of internal medicine 2015-09-01 Drug development

    Ankylosing spondylitis is associated with increased risk for vascular mortality.

  10. Experimental Rodent Models of Vascular Dementia: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. CNS & neurological disorders drug targets 2021 Vascular contributions

    Vascular Dementia (VaD) occurs due to cerebrovascular insufficiency, which leads to decreased blood circulation to the brain, thereby resulting in mental disabilities.

  11. APOE4 derived from astrocytes leads to blood-brain barrier impairment

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Brain : a journal of neurology 2022-10-21 Genetics

    Apolipoprotein E (ApoE) is a multifaceted secreted molecule synthesized in the CNS by astrocytes and microglia, and in the periphery largely by the liver.

  12. Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Alzheimer's & dementia (New York, N. Y.) 2021-03-24 Biomarkers

    The innate immune system is a viable target for therapeutic intervention in AD.

  13. CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Journal of Alzheimer's disease : JAD 2020-01-01 Biomarkers

    CCL23 is a chemokine implicated in inflammation and host defense responses.

  14. An early and late peak in microglial activation in Alzheimer's disease trajectory

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Brain : a journal of neurology 2017-03-01 Mild cognitive impairment

    Amyloid-β deposition, neuroinflammation and tau tangle formation all play a significant role in Alzheimer's disease.

  15. CSF biomarkers of neuroinflammation are associated with regional atrophy

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Journal of neurology 2025-12-24 Inflammation and the immune system

    Higher synaptic latent factor (β = - 0.019, pFDR = 0.021) and YKL-40 (β = - 0.020, pFDR = 0.025) significantly predicted hippocampal atrophy.

  16. The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature communications 2025-01-16 Genetics

    Dysregulated microglia activation, leading to neuroinflammation, is crucial in neurodegenerative disease development and progression.

  17. GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Brain 2015-08-11 Genetics

    Brain amyloid deposition is thought to be a seminal event in Alzheimer’s disease.

  18. Inflammation in dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurobiology of disease 2022-03-18 Brain tissue and pathology

    Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD).

  19. A map of transcriptional heterogeneity and regulatory variation in human microglia

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature genetics 2021-06-03 Genetics

    Microglia, the tissue-resident macrophages of the central nervous system (CNS), play critical roles in immune defense, development and homeostasis.

  20. Systemic inflammation and disease progression in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurology 2009-09-01 Inflammation and the immune system

    Both acute and chronic systemic inflammation, associated with increases in serum tumor necrosis factor alpha, is associated with an increase in cognitive decline in Alzheimer disease.

  21. Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. PubMed 2009-07-01 Vascular contributions

    G) Functions, such as vessel stabilization, regulation of vascular tone and maintenance of local and tissue homeostasis (contractile capacity and vessel permeability regulation), matrix protein synthesis, macrophage-like properties, immunological defense, intervention in coagulation, participation in mechanisms that regulate the quiescent and angiogenic stages of blood vessels (including the behaviour of pericytes during sprouting angiogenesis and intussuceptive vascular growth, as well as pericyte interactions with endothelium and other cells, and with extracellular matrix) and plasticity, as progenitor cells with great mesenchymal potential, originating other pericytes, fibroblast/myofibroblasts, preadipocytes, chondroblasts, osteoblasts, odontoblasts, vascular smooth muscle and myointimal cells.

  22. Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Acta neuropathologica communications 2024-05-07 Brain tissue and pathology

    Morphologically, reactive and amoeboid microglia were common in mixed DLB + AD, while homeostatic microglia with a small soma and thin processes were observed in pure DLB cases.

  23. Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Ageing research reviews 2017-10-07 Risk factors

    Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-related pathologies and natural processes in aging tissue, including the nervous system.

  24. Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2022-06-14 Tau biomarkers

    A total of 96 proteins were decreased in MCI-SNAP compared to CN and MCI-AD.

  25. Proinflammatory cytokines, aging, and age-related diseases

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of the American Medical Directors Association 2013-06-20 Inflammation and the immune system

    Inflammation is a physiological process that repairs tissues in response to endogenous or exogenous aggressions.

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