Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Recurrent depression is associated with smaller hippocampal volume which is most prominent in the posterior hippocampus.
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41/100
Both Kraepelin [1919. Dementia Praecox and Paraphrenia, Livingston, Edinburgh.] and Bleuler [1911.
Why it matters
This review concerns schizophrenia, reporting links between brain structure and thinking abilities in people with that condition. It contains nothing about treating, curing, or preventing Alzheimer's disease.
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41/100
The authors summarize the dementia caregiving literature and provide recommendations regarding practice guidelines for health professionals working with caregivers.
Why it matters
This review summarises the dementia caregiving literature and recommends practice guidelines and support strategies for health professionals working with caregivers. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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A study was performed on patients with Alzheimer's disease (AD) in order to evaluate the efficacy of a combined treatment (donepezil plus cognitive training) in both cognitive processes and affective states.
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41/100
Patients receiving chronic corticosteroid therapy have smaller hippocampal volumes, lower N-acetyl aspartate ratios, and declarative memory deficits compared with controls.
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Virtually all respondents reported increased skill, knowledge, and confidence, and all would recommend the program to others.
Why it matters
The Savvy Caregiver Program, a 12-hour training for family caregivers, was tested across several sites and caregivers reported increased skill, knowledge, and confidence, with improved well-being measures. This is about supporting caregivers, not about treating, curing, or preventing Alzheimer's disease.
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Aging is often accompanied by learning and memory problems, many of which resemble deficits associated with hippocampal damage.
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Grey matter volume in the posterior hippocampus of London taxi drivers is greater than in age-matched controls, and the size of this increase correlates positively with time spent taxi driving (E.A.
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Thirty patients (16 male) were diagnosed as having PPFG (mean age at onset, 72.2 years; mean duration of disease, 5 years).
Why it matters
This review of 30 patients describes the natural history of primary progressive freezing gait, with brain imaging normal or showing minor nonspecific changes in most cases. It concerns this syndrome's course, not treating, curing, or preventing Alzheimer's disease.
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We compared voxel-based morphometry (VBM) with independent accurate region-of-interest (ROI) measurements of temporal lobe structures in order to validate the usefulness of this fully automated and unbiased technique in Alzheimer's disease (AD) and semantic dementia (SD).
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We conducted an open, prospective trial of olanzapine for the treatment of delirium in a sample of 79 hospitalized cancer patients.
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Parkinson's disease patients may suffer from cognitive impairment and behavioural problems such as apathy, personality changes, speech disturbances and visual hallucinations (Parkinson's disease dementia).
Why it matters
This case series reports that rivastigmine improved cognitive and functional abilities and resolved behavioural problems and visual hallucinations in patients with Parkinson's disease dementia. It is a small case series about Parkinson's disease dementia and does not test any treatment, cure, or prevention for Alzheimer's disease.
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In 1994-1995, a screening and examination survey was conducted to ascertain the prevalence of dementia, Parkinson's disease and stroke in two urban communities and one rural community of central Spain.
Why it matters
This paper uses a survey in central Spain to illustrate nonclinical problems in conducting two-phase prevalence surveys, especially screening nonparticipation and screening validation. It is about survey methods, not about treating, curing, or preventing Alzheimer's disease.
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There was no significant difference between patients with dementia or depression in their wish to know their diagnosis.
Why it matters
Most patients with dementia and depression liked the idea of reading their diagnosis, though 25% of dementia cases felt upset. This concerns how patients react to being told their diagnosis, not treating, curing or preventing Alzheimer's disease.
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Practice standards in medical genetics provide an implicit guide to the ethical, legal, and social implications (ELSI) of genetic tests.
Why it matters
This paper categorizes genetic tests by their clinical validity and whether effective treatment exists, and notes that testing for APOE to predict Alzheimer disease risk is generally recommended against. The reasoning is that APOE testing has limited clinical validity and no effective treatment, so avoiding harm justifies not recommending it.
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Dementia is frequent after ischemic or hemorrhagic stroke.
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The results of our study indicate no reduction in the volume of the hippocampus in patients with major depression.
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Children born preterm and of very low birth weight have an increased incidence of learning difficulties, but little is known about the specific nature of their cognitive deficits and the underlying neuropathology.
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Dementia of Alzheimer Type (DAT) is increasingly detected at an earlier stage of the disorder, when interventions to assist with everyday memory difficulties might be most valuable.
Why it matters
This small study of 6 people with early stage Alzheimer's disease tested individually tailored memory training based on errorless learning principles. It suggests some learning may be possible in early Alzheimer's disease, but it does not show any effect on curing or preventing the disease.
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Two hundred and eighty-seven patients were tested: 135 controls (GDS 1-2), 70 with mild dementia (GDS 3-5) and 82 with more severe dementia (GDS 6-7).
Why it matters
This study found that the 6 Item Cognitive Impairment Test correlated well with the Mini-Mental State Examination and outperformed it in milder dementia. It is about a screening tool for dementia, not about treating, curing, or preventing Alzheimer's disease.
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HIV infection often results in neuropsychological (NP) impairment.
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Down syndrome (DS) is the most common cause of mental retardation in North America, yet little information is available on the natural history of DS in adults.
Why it matters
This report on 38 adults with Down syndrome over 12 years lists significant health problems, including complications from presenile dementia or Alzheimer-type disease in 42%. It is a descriptive health care review and offers no treatment, cure, or prevention for Alzheimer's disease.
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Senile dementia with tangles is a sporadic subset of very late onset dementia with preponderance in females over age 80 years.
Why it matters
This review describes senile dementia with tangles as a sporadic very late-onset dementia with neurofibrillary tangles limited to limbic areas and absence of neuritic plaques, with a very low prevalence of the ApoE ε4 allele. It suggests this may be a variant of Alzheimer's disease in the oldest-old, but its nosological position remains controversial.
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1. Sexual dimorphism of human brain anatomy has not been well-studied between 4 and 18 years of age, a time of emerging sex differences in behavior and the sexually specific hormonal changes of adrenarche (the predominantly androgenic augmentation of adrenal cortex function occurring at approximately age 8) and puberty. 2.
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41/100
Cognitive impairment has been reported in middle aged patients with end stage heart failure.
Why it matters
In 57 older patients with mild to moderate heart failure, cognitive impairment was common and was linked to left ventricular dysfunction. This describes an association only and does not show that treating heart failure prevents or cures Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Mitigating the negative impacts of aging on cognitive function; modifiable factors associated with increasing cognitive reserve
- A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool
- Maintaining older brain functionality: A targeted review
- Test–retest reliability of the computer-based cognitive assessment tool for community-dwelling older adults in Japan: The Otassha study
- A systemic review of the roles of n-3 fatty acids in health and disease
- Mild cognitive impairment and everyday function: an investigation of driving performance
- The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old
- Utilization Patterns and Clinical Factors Associated With Hospitalization in Early‐Stage Dementia With Lewy Bodies
- Ginkgo biloba extract: mechanisms and clinical indications
- Caregiver burden for informal caregivers of patients with dementia: A systematic review