Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

These counts and lists are worked out from the library itself each time the page loads. A score rates how much weight a study can bear — its design, journal, evidence and recency — not whether its result is good news. How we score a study. For a plain-English guide to this subject, see Prevention.

The 20 highest-scoring studies

  1. An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial Nature medicine · 2025-01-28 · · Peer-reviewed
  2. Effect of long-term physical exercise and multidomain interventions on cognitive function and the risk of mild cognitive impairment and dementia in older adults: A systematic review with meta-analysis Ageing research reviews · 2024-08-22 · · Peer-reviewed
  3. Speed of processing training results in lower risk of dementia Alzheimer's & dementia (New York, N. Y.) · 2017-11-07 · · Peer-reviewed
  4. Alzheimer's Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis Journal of clinical medicine · 2021-10-10 · · Peer-reviewed
  5. An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-09-04 · · Peer-reviewed
  6. Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial Neurology · 2026-07-20 · · Peer-reviewed
  7. Multi-domain interventions for the prevention of dementia and cognitive decline The Cochrane database of systematic reviews · 2021-11-08 · · Peer-reviewed
  8. Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-04-22 · · Peer-reviewed
  9. Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial European heart journal · 2022-06-01 · · Peer-reviewed
  10. Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-04-22 · · Peer-reviewed
  11. The Impact of Pandemic-Related Restrictions on Dementia Risk Factors in Older Adults Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023-11-06 · · Peer-reviewed
  12. Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial JAMA network open · 2023-07-03 · · Peer-reviewed
  13. Computerized cognitive training for memory functions in mild cognitive impairment or dementia: a systematic review and meta-analysis NPJ digital medicine · 2024-01-03 · · Peer-reviewed
  14. Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial Aging · 2021-06-18 · · Peer-reviewed
  15. Effects of a multidomain intervention against cognitive decline on dementia risk profiles - Results from the AgeWell.de trial Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-07-05 · · Peer-reviewed
  16. Impact of the COVID-19 Pandemic on Older Adults: Rapid Review JMIR aging · 2021-04-12 · · Peer-reviewed
  17. Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer's disease: the MIND-ADmini randomized controlled trial Alzheimer's research & therapy · 2024-05-30 · · Peer-reviewed
  18. Can Exercise Improve Cognitive Symptoms of Alzheimer's Disease? Journal of the American Geriatrics Society · 2018-01-24 · · Peer-reviewed
  19. Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers PLoS medicine · 2014-11-18 · · Peer-reviewed
  20. A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023-09-28 · · Peer-reviewed

See all 835 studies in Prevention trials, with filters →

Newest additions on this subject

All 835 studies in Prevention trials, newest first →

What the library holds on this subject

By review status

StatusStudies
Peer-reviewed821
Preprint — not yet peer-reviewed14

By usefulness score

Score bandStudies
70+156
50–69255
30–49400
Under 3024

By strength of evidence

Rated in our summaryStudies
low408
high311
moderate115
not rated1

Most frequent journals

JournalStudies
Journal of Alzheimer's disease : JAD42
Nutrients24
Frontiers in aging neuroscience20
Alzheimer's & dementia : the journal of the Alzheimer's Association18
Neurology15
The journal of prevention of Alzheimer's disease14
Ageing research reviews13
Alzheimer s & Dementia12
Alzheimer's research & therapy12
The journal of nutrition, health & aging11

Studies by year published

Prevention trials studies in the library by year published
YearStudiesBar
202657
2025132
202429
202325
202248
202168
202073
201965
201854
201744
201642
201530
201435
201334
201219
201114
201018
20099
20088
20076
20067
20053
20046
20031
20023
19992
19921
19861
19811

Counts the 835 studies with a usable publication date. The library is a large sample of published work, not a complete index, so these counts describe the library, not the whole field.

Other subjects in the library

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