Home › Research › Prevention trials
Can Exercise Improve Cognitive Symptoms of Alzheimer's Disease?
Gregory A Panza, Beth A Taylor, Hayley V MacDonald, Blair T Johnson, Amanda L Zaleski, Jill Livingston, Paul D Thompson, Linda S Pescatello. Journal of the American Geriatrics Society, 2018-01-24
Topic: Brain imaging, connectivity and assessment
Exercise interventions were performed 3.4 ± 1.4 days per week at moderate intensity (3.7 ± 0.6 metabolic equivalents) for 45.2 ± 17.0 minutes per session for 18.6 ± 10.0 weeks and consisted primarily of aerobic exercise (65%). Overall, there was a modest favorable effect of exercise on cognitive function (d+ = 0.47, 95% confidence interval (CI) = 0.26-0.68). Within-group analyses revealed that exercise improved cognitive function (d+w = 0.20, 95% CI = 0.11-0.28), whereas cognitive function declined in the control group (d+w = -0.18, 95% CI = -0.36 to 0.00). Aerobic exercise had a moderate favorable effect on cognitive function (d+w = 0.65, 95% CI = 0.35-0.95), but other exercise types did not (d+w = 0.19, 95% CI = -0.06-0.43). Our findings suggest that exercise training may delay the decline in cognitive function that occurs in individuals who are at risk of or have AD, with aerobic exercise possibly having the most favorable effect. Additional randomized controlled clinical trials that include objective measurements of cognitive function are needed to confirm our findings.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Panza, G. A., Taylor, B. A., MacDonald, H. V., Johnson, B. T., Zaleski, A. L., Livingston, J., et al. (2018). Can Exercise Improve Cognitive Symptoms of Alzheimer's Disease? Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.15241
Vancouver
Panza GA, Taylor BA, MacDonald HV, Johnson BT, Zaleski AL, Livingston J, et al. Can Exercise Improve Cognitive Symptoms of Alzheimer's Disease? Journal of the American Geriatrics Society. 2018. doi:10.1111/jgs.15241. PMID: 29363108.
BibTeX
@article{panza2018-29363108,
author = {Panza, Gregory A and Taylor, Beth A and MacDonald, Hayley V and Johnson, Blair T and Zaleski, Amanda L and Livingston, Jill and Thompson, Paul D and Pescatello, Linda S},
title = {{Can Exercise Improve Cognitive Symptoms of Alzheimer's Disease?}},
journal = {Journal of the American Geriatrics Society},
year = {2018},
doi = {10.1111/jgs.15241},
pmid = {29363108},
url = {https://doi.org/10.1111/jgs.15241}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Exercise interventions were performed 3.4 ± 1.4 days per week at moderate intensity (3.7 ± 0.6 metabolic equivalents) for 45.2 ± 17.0 minutes per session for 18.6 ± 10.0 weeks and consisted primarily of aerobic exercise (65%).
- Overall, there was a modest favorable effect of exercise on cognitive function (d+ = 0.47, 95% confidence interval (CI) = 0.26-0.68).
- Within-group analyses revealed that exercise improved cognitive function (d+w = 0.20, 95% CI = 0.11-0.28), whereas cognitive function declined in the control group (d+w = -0.18, 95% CI = -0.36 to 0.00).
- Aerobic exercise had a moderate favorable effect on cognitive function (d+w = 0.65, 95% CI = 0.35-0.95), but other exercise types did not (d+w = 0.19, 95% CI = -0.06-0.43).
- Our findings suggest that exercise training may delay the decline in cognitive function that occurs in individuals who are at risk of or have AD, with aerobic exercise possibly having the most favorable effect.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designmeta-analysis
- Participants1,145
- Effect sizeor 45.2; or 18.6
- Evidence strengthHigh
How this study scored 82/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 46 of the 56 points we could judge it on, which is 82 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Geriatrics Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,145 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29363108) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 46 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 46 of the 56 points we could judge it on is 82 out of 100. |
| Total | 82 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related
Studies in the library that share something with this one. The line above each title says what.
Related studies in Prevention trials
Also tagged “exercise-training”
125 studies in the library carry the topic tag “exercise-training”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 125 tagged studies.