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An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba
Oki Y, Osaki T, Kumagai R, Murata S, Encho H, Ono R, Yasuda H, Kowa H.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024-09-04
Topic: Risk, prevention and care in population studies
Background The number of people with dementia is increasing in Japan, and establishing evidence for preventing dementia is necessary. Methods This study was a randomized controlled trial in cognitively normal community-dwelling older adults aged 65 to 85 with diabetes and/or hypertension. Participants were randomly assigned in a 1:1 ratio. The intervention group underwent 90 min of group-based weekly physical exercise, cognitive training, nutritional counseling, and vascular risk management for 18 months. The primary endpoint was the change in a cognitive composite score calculated by averaging the z-scores of seven neuropsychological tests from baseline to 18 months. Results We randomly assigned 203 participants to two groups, and 178 (87.7%) completed the 18-month follow-up. There was a significant group difference in the cognitive composite score change at 18 months (mean difference 0.16, 95% confidence interval: 0.04 to 0.27; p = 0.009). Discussion An 18-month multimodal intervention for older adults at risk of dementia could improve their cognitive function. The trial was registered in the Clinical Trial Registration System (UMIN000041938). Highlights Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT) PRIME Tamba was a randomized controlled trial to prevent dementia. We provided a multifactorial intervention based on the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) trial methodology. The primary outcome, the cognitive composite score, improved with our intervention. Executive function/processing speed and memory improved in the intervention group. Intervention adherence was high, and no serious adverse events occurred.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Oki, Y., Osaki, T., Kumagai, R., Murata, S., Encho, H., Ono, R., et al. (2024). An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.14170
Vancouver
Oki Y, Osaki T, Kumagai R, Murata S, Encho H, Ono R, et al. An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1002/alz.14170. PMID: 39229900.
BibTeX
@article{oki2024-39229900,
author = {Oki, Y. and Osaki, T. and Kumagai, R. and Murata, S. and Encho, H. and Ono, R. and Yasuda, H. and Kowa, H.},
title = {{An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2024},
doi = {10.1002/alz.14170},
pmid = {39229900},
url = {https://doi.org/10.1002/alz.14170}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results We randomly assigned 203 participants to two groups, and 178 (87.7%) completed the 18-month follow-up.
- There was a significant group difference in the cognitive composite score change at 18 months (mean difference 0.16, 95% confidence interval: 0.04 to 0.27; p = 0.009).
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Study details
- Study designrandomized controlled trial
- Participants203
- Effect size87.7%
- Evidence strengthHigh
How this study scored 88/100
Published in a leading specialty journal, and it is a randomised controlled trial. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 51 of the 58 points we could judge it on, which is 88 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 203 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39229900) |
| Free to read | 2 / 2 | Free to read |
| Points | 51 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 51 of the 58 points we could judge it on is 88 out of 100. |
| Total | 88 / 100 | — |
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