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Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial
Da Ae Kim, Sun Min Lee, Kyunghwa Sun, Ji Hyun Park, Yoo Kyoung Park, Jee Hyang Jeong, Chang Hyung Hong, Jiwoo Jung et al.. Neurology, 2026-07-20
Topic: Brain imaging, connectivity and assessment
Of 300 randomized participants, 277 participants (mean age, 72.9 years; 69.3% female) were included in the modified intention-to-treat analysis (142 in the MLI group and 135 in the control group). MLI significantly improved RBANS total index scores compared with control at 24 weeks (between-group difference, 4.17 points; 95% CI 1.92-6.43). No subgroup interactions remained significant after false discovery rate correction, indicating consistent effects across subgroups. In this subgroup analysis of the SUPERBRAIN-MEET trial, the cognitive benefits of MLI were not significantly modified by sociodemographic factors, digital readiness, baseline cognitive status, or vascular risk profiles. These findings should be interpreted with caution, given the exploratory nature of subgroup analyses and limited statistical power. The results support the generalizability and scalability of technology-assisted multidomain lifestyle interventions for dementia prevention in older adults with MCI. TRIAL REGISTRATION INFORMATION: The trial was registered at ClinicalTrials.gov (NCT05023057; submitted August 20, 2021; first patient enrolled September 3, 2021; URL: clinicaltrials.gov/study/NCT05023057).
Key findings
- Of 300 randomized participants, 277 participants (mean age, 72.9 years; 69.3% female) were included in the modified intention-to-treat analysis (142 in the MLI group and 135 in the control group).
- MLI significantly improved RBANS total index scores compared with control at 24 weeks (between-group difference, 4.17 points; 95% CI 1.92-6.43).
- No subgroup interactions remained significant after false discovery rate correction, indicating consistent effects across subgroups.
- In this subgroup analysis of the SUPERBRAIN-MEET trial, the cognitive benefits of MLI were not significantly modified by sociodemographic factors, digital readiness, baseline cognitive status, or vascular risk profiles.
- These findings should be interpreted with caution, given the exploratory nature of subgroup analyses and limited statistical power.
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Study details
- Study designrandomized controlled trial
- Participants277
- Effect size69.3%
- Evidence strengthHigh
How this study scored 88/100
Published in a leading specialty journal, and it is a randomised controlled trial. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and free to read, so those were left out: it earned 52 of the 59 points we could judge it on, which is 88 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 277 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42475653) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 52 / 59 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 52 of the 59 points we could judge it on is 88 out of 100. |
| Total | 88 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Kim, D. A., Lee, S. M., Sun, K., Park, J. H., Park, Y. K., Jeong, J. H., et al. (2026). Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial. Neurology. https://doi.org/10.1212/wnl.0000000000218297
Vancouver
Kim DA, Lee SM, Sun K, Park JH, Park YK, Jeong JH, et al. Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial. Neurology. 2026. doi:10.1212/wnl.0000000000218297. PMID: 42475653.
BibTeX
@article{kim2026-42475653,
author = {Kim, Da Ae and Lee, Sun Min and Sun, Kyunghwa and Park, Ji Hyun and Park, Yoo Kyoung and Jeong, Jee Hyang and Hong, Chang Hyung and Jung, Jiwoo and others},
title = {{Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial}},
journal = {Neurology},
year = {2026},
doi = {10.1212/wnl.0000000000218297},
pmid = {42475653},
url = {https://doi.org/10.1212/wnl.0000000000218297}
}