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16/100

⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Prevention trials

Topic: Brain imaging, connectivity and assessment

Introduction Individuals diagnosed with mild cognitive impairment (MCI) have an increased risk of developing dementia. Since there are currently no curative pharmacological therapies for MCI, nonpharmacological and exercise-related medical therapies represent a promising approach. This study aims to evaluate the effects of nonpharmacological interventions on cognitive performance in individuals with MCI. Methods and analysis The study will be a prospective, randomized, sham-controlled, single-centre superiority trial with a parallel-group design. A total of 100 patients aged ≥ 60 years with MCI will be randomly assigned to one of the three intervention groups or the control group. The three intervention arms comprise high-intensity interval training (HIIT), yoga, and intermittent hypoxia-hyperoxia exposure (IHHE), whereas participants in the control group will receive a sham application of IHHE (IHHE-S). The primary outcome is the cognitive function after 3-month intervention period assessed by Montreal Cognitive Assessment. The secondary outcomes and the evaluation of modifiable risk factors for dementia include quality of life, laboratory data, physical activity, anthropometric data, and cardiorespiratory fitness. All harms and (serious) adverse events will be assessed systematically at each study visit. Ethics and dissemination This study has been approved by the Ethics committee of the Medical Faculty of the University of Tübingen (494/2025BO1). Research findings will be published in peer-reviewed journals and presented to stakeholders and at scientific conferences. Trial registration The study was registered on the German Clinical Trial Register DRKS on 04.12.2025 (DRKS00038438). Strengths and limitations of this study - The randomized, sham-controlled study design represents a key methodological strength, allowing reliable comparisons between the intervention groups and the control group while accounting for potential placebo effects. - The 12-month follow-up from baseline provides the opportunity to evaluate the long-term effects of the interventions. - Blinding of participants and therapists cannot be fully implemented across all study groups because of the nature of the interventions.

Key findings

Introduction Individuals diagnosed with mild cognitive impairment (MCI) have an increased risk of developing dementia.

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Study details

Participants100
Evidence strengthHigh

How this study scored 16/100

Preprint — not yet peer-reviewed. It scored 37 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design and effect reported because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 23 of the 62 points we could judge it on, which is 37 out of 100.

Component	Points	Why
Journal tier	2 / 10	Tier 4 — not a peer-reviewed journal (medRxiv)
Journal's citation record	0 / 4	Not a journal article, so the journal's record does not count
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	4 / 10	Preprint — not yet peer-reviewed. Hosted on a preprint server.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	2 / 4	100 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	1 / 2	Not in PubMed, but has a DOI
Free to read	0 / 2	Behind a paywall — scores zero
Points	23 / 62	Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 23 of the 62 points we could judge it on is 37 out of 100.
Total	37 / 100	Capped to 16 because this is not a peer-reviewed article.

What each of these 20 components measures, and what this score is not →

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Wagner, S., Haigis, D., Bilc, M., Beiner, E., Nieß, A. M., Fallgatter, A. J., et al. (2026). The effectiveness and safety of high-intensity interval training, yoga and intermittent hypoxia-hyperoxia exposure on cognitive performance and health in individuals with mild cognitive impairment (KAYH): a study protocol for a randomized, sham-controlled trial. medRxiv. https://doi.org/10.64898/2026.08.05.26359785

Vancouver

Wagner S, Haigis D, Bilc M, Beiner E, Nieß AM, Fallgatter AJ, et al. The effectiveness and safety of high-intensity interval training, yoga and intermittent hypoxia-hyperoxia exposure on cognitive performance and health in individuals with mild cognitive impairment (KAYH): a study protocol for a randomized, sham-controlled trial. medRxiv. 2026. doi:10.64898/2026.08.05.26359785.

BibTeX

@article{wagner2026-f7d2ca48,
  author  = {Wagner, S. and Haigis, D. and Bilc, M. and Beiner, E. and Nieß, A. M. and Fallgatter, A. J. and Eschweiler, G. W. and Krauß, I. and others},
  title   = {{The effectiveness and safety of high-intensity interval training, yoga and intermittent hypoxia-hyperoxia exposure on cognitive performance and health in individuals with mild cognitive impairment (KAYH): a study protocol for a randomized, sham-controlled trial}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.05.26359785},
  url     = {https://doi.org/10.64898/2026.08.05.26359785}
}

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