- 162studies on this subject, of 27,380 in the library
- 145peer-reviewed
- 1981–2026years published
- 61median usefulness score out of 100
These counts and lists are worked out from the library itself each time the page loads. A score rates how much weight a study can bear — its design, journal, evidence and recency — not whether its result is good news. How we score a study. For a plain-English guide to this subject, see Registered clinical trials.
The 20 highest-scoring studies
- MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial
- Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial
- Study of mirtazapine for agitated behaviours in dementia (SYMBAD): a randomised, double-blind, placebo-controlled trial
- Randomized, double-blind study of zervimesine in mild to moderate Alzheimer's disease
- Efficacy assessment of an active tau immunotherapy in Alzheimer's disease patients with amyloid and tau pathology: a post hoc analysis of the "ADAMANT" randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trial
- A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease
- Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial
- A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment
- Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial
- Memory Complaints and Cognitive Decline: Data from the GUIDAGE Study1
- Safety and Tolerability of GRF6019 Infusions in Severe Alzheimer's Disease: A Phase II Double-Blind Placebo-Controlled Trial
- Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial
-
Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (EVOKE and EVOKE+): two phase 3, randomised, placebo-controlled trials
In two Phase 3 trials of 3,808 participants, oral semaglutide showed no significant difference from placebo in clinical decline on the main measure, and Novo Nordisk ended its Alzheimer's program for the drug after this result. Some biomarker reductions did not translate into any detectable slowing of cognitive or functional decline.
- A phase 2 randomized, placebo-controlled study on the efficacy and safety of AR1001, a phosphodiesterase-5 inhibitor, in patients with mild-to-moderate Alzheimer's disease
- Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial
- Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab
- Communication Bridge-2 randomized controlled trial: Recruitment and baseline features
- A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease
- Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial
- A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group
See all 162 studies in Clinical trials, with filters →
Newest additions on this subject
- Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol
- Amyloid and Tau Neuropathologic Stage, Coexisting Brain Disease, and Cognitive Status in a Population-Based Autopsy Cohort
- The Effect of Noncontingent Monetary Incentives in Recruitment Letters on Research Enrollment of Alzheimer’s Disease and Related Dementia Caregiving Dyads: A Study Within a Trial (SWAT) Randomized Controlled Trial
- Ceperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial
- The effects of virtual reality and video conferencing on personal and relational well-being among older adults with cognitive impairments and their adult children: The Thrive randomized controlled trial
- Efficacy of Curcumin in Neurodegenerative Diseases: From Pharmacokinetic Barriers to Advanced Delivery Systems
- The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation with Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: The HELI Randomised Controlled Trial
- Building Cognitive Lines of Defense: A Life-Course Prevention Strategy for Alzheimer's Disease—An Evidence-Based Multi-Stage Intervention Protocol
- New Alzheimer’s Disease Diagnostics and Psychological Clinical Perspectives
- Effects of Practice Testing with Corrective Feedback on Long-Term BPSD Knowledge in Dementia Caregivers: Randomized Controlled Trial
All 162 studies in Clinical trials, newest first →
What the library holds on this subject
By review status
| Status | Studies |
|---|---|
| Peer-reviewed | 145 |
| Preprint — not yet peer-reviewed | 12 |
| Conference abstract — not peer-reviewed | 3 |
| Press release — not a study | 2 |
By strength of evidence
| Rated in our summary | Studies |
|---|---|
| high | 86 |
| low | 50 |
| moderate | 9 |
| early | 6 |
| null-result | 6 |
| preliminary | 3 |
| not rated | 2 |
Most frequent journals
| Journal | Studies |
|---|---|
| Journal of Alzheimer's disease : JAD | 10 |
| Neurology | 10 |
| JAMA | 8 |
| Alzheimer's & dementia : the journal of the Alzheimer's Association | 6 |
| Alzheimer's research & therapy | 6 |
| The Lancet. Neurology | 6 |
| The journal of prevention of Alzheimer's disease | 6 |
| medRxiv | 6 |
| Research Square | 4 |
| Alzheimer's & Dementia | 3 |
Studies by year published
| Year | Studies | Bar |
|---|---|---|
| 2026 | 22 | |
| 2025 | 13 | |
| 2024 | 9 | |
| 2023 | 13 | |
| 2022 | 10 | |
| 2021 | 14 | |
| 2020 | 2 | |
| 2019 | 2 | |
| 2018 | 4 | |
| 2017 | 7 | |
| 2016 | 5 | |
| 2015 | 4 | |
| 2014 | 4 | |
| 2013 | 1 | |
| 2012 | 3 | |
| 2011 | 2 | |
| 2010 | 4 | |
| 2009 | 4 | |
| 2008 | 3 | |
| 2007 | 1 | |
| 2006 | 3 | |
| 2005 | 1 | |
| 2004 | 3 | |
| 2003 | 1 | |
| 2002 | 3 | |
| 2001 | 3 | |
| 2000 | 2 | |
| 1999 | 1 | |
| 1998 | 1 | |
| 1997 | 3 | |
| 1996 | 2 | |
| 1994 | 2 | |
| 1993 | 1 | |
| 1992 | 2 | |
| 1991 | 1 | |
| 1990 | 3 | |
| 1988 | 1 | |
| 1986 | 1 | |
| 1981 | 1 |
Counts the 162 studies with a usable publication date. The library is a large sample of published work, not a complete index, so these counts describe the library, not the whole field.
Other subjects in the library
- Getting a diagnosis
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- Mild cognitive impairment
- Risk genes beyond APOE
- Brain scans and imaging
- TREM2 and immune genetics
- Cognitive tests and assessment
- Lewy body dementia
- Down syndrome and Alzheimer's
- Long-term cohort studies
- Inflammation and the immune system
- Tau biomarkers
- Brain tissue and pathology
- Drug development
- Hippocampus size on brain scans