- 1,459studies on this subject, of 27,380 in the library
- 1,385peer-reviewed
- 1961–2026years published
- 46median usefulness score out of 100
These counts and lists are worked out from the library itself each time the page loads. A score rates how much weight a study can bear — its design, journal, evidence and recency — not whether its result is good news. How we score a study. For a plain-English guide to this subject, see Brain scans & tests.
The 20 highest-scoring studies
- Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies
- Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastrooesophageal reflux
- Research Criteria for the Behavioral Variant of Alzheimer Disease: A Systematic Review and Meta-analysis
- Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis
- Diabetes in Older Adults: A Consensus Report
- Donanemab (LY3002813) Phase 1b Study in Alzheimer's Disease: Rapid and Sustained Reduction of Brain Amyloid Measured by Florbetapir F18 Imaging
- Optical Coherence Tomography in Patients with Alzheimer's Disease: What Can It Tell Us?
- Trial of Solanezumab in Preclinical Alzheimer's Disease
- Tau-PET imaging in Parkinson's disease: a systematic review and meta-analysis
- Electroacupuncture improves vascular cognitive impairment no dementia: A Randomized Clinical Trial
- Meta-analysis of amyloid-cognition relations in cognitively normal older adults
- The hubs of the human connectome are generally implicated in the anatomy of brain disorders
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Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study
In people from families with inherited (autosomal dominant) Alzheimer's disease, brain scans of mutation carriers began to differ from those of non-carrier relatives in a set order: amyloid deposition first (on average 18.9 years before expected onset), then reduced glucose metabolism (14.1 years), then structural decline (4.7 years). These figures are averages across brain regions of when the differences became statistically detectable, not personal timelines, and they varied by several years. The study shows these changes come before the expected start of dementia in this inherited form; it does not show that one change causes the next, or that the same timing applies to late-life Alzheimer's.
- Optical coherence tomography in mild cognitive impairment - Systematic review and meta-analysis
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Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis
In this meta-analysis, among people with high amyloid, female sex was associated with faster tau accumulation in certain brain regions, and among APOE ε4 carriers female sex was associated with faster tau accumulation in the inferior temporal region. The authors suggest these sex differences call for sex-specific timing considerations when giving anti-amyloid and anti-tau therapies, but no treatment was tested here.
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Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity
In 6,514 people, a positive tau PET scan was rare before age 50 but was estimated at 19% of cognitively unimpaired people by age 90, and at 79% of people with Alzheimer's dementia at age 75. Among cognitively unimpaired people, those positive on both amyloid and tau PET had an estimated 57% five-year risk of developing MCI or dementia, compared with 17% for amyloid-positive/tau-negative and 6% for people negative on both. The authors note this was a convenience sample and describe tau PET as a promising staging marker. These are associations, not a prediction for any one person.
- Non-stationarity in the "resting brain's" modular architecture
- Combining CSF MTBR-tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease
- Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis
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Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study
In brain tissue and blood samples, certain sphingolipid species were associated with severity of Alzheimer pathology at autopsy and with increased risk of future conversion to Alzheimer disease in cognitively normal individuals. The study notes its relatively small number of brain tissue samples as a limitation.
See all 1,459 studies in Brain scans and imaging, with filters →
Newest additions on this subject
- Large-scale head-to-head comparison of on- and off-target profiles of [18F]Tauvid and [18F]MK6240 tau-PET in aging and Alzheimer’s disease
- Repetitive negative thinking is associated with amyloid accumulation over 3 years in cognitively healthy adults
- Tau-CTFP: A connectome-informed continuous-time first-passage model for forecasting the onset of regional tau PET abnormality
- Endocannabinnoids innervate Circadian mechinary mitigating neuroinflammation, amyloidogenesis and cognition phenotypic to AD
- A Wasserstein Weisfeiler-Lehman Kernel Framework for Multimodal Brain Connectome Analysis
- From group-level neurophysiological biomarkers to individual-level phenotyping to identify mechanisms of neurodegenerative disease
- Second-generation tau PET tracer in situ binding assessed with fluorescence imaging
- Current gaps in downstream applications of fMRI foundation models: lessons learned from BrainLM & BrainHarmonix on Prevent-AD
- TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models
- MVMGNN: Multi-View Masked Graph Neural Network for Alzheimer’s Disease Diagnosis using Structural MRI
All 1,459 studies in Brain scans and imaging, newest first →
What the library holds on this subject
By review status
| Status | Studies |
|---|---|
| Peer-reviewed | 1,385 |
| Preprint — not yet peer-reviewed | 73 |
| Retracted — do not rely on it | 1 |
By strength of evidence
| Rated in our summary | Studies |
|---|---|
| low | 1,075 |
| moderate | 313 |
| high | 37 |
| not rated | 34 |
Most frequent journals
| Journal | Studies |
|---|---|
| Neurology | 176 |
| Brain : a journal of neurology | 40 |
| Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 40 |
| NeuroImage | 40 |
| Annals of neurology | 38 |
| Alzheimer's & dementia : the journal of the Alzheimer's Association | 37 |
| Journal of Alzheimer's disease : JAD | 28 |
| Neurobiology of aging | 28 |
| Alzheimer's & dementia (Amsterdam, Netherlands) | 23 |
| JAMA neurology | 22 |
Studies by year published
| Year | Studies | Bar |
|---|---|---|
| 2026 | 111 | |
| 2025 | 119 | |
| 2024 | 50 | |
| 2023 | 51 | |
| 2022 | 74 | |
| 2021 | 66 | |
| 2020 | 78 | |
| 2019 | 75 | |
| 2018 | 74 | |
| 2017 | 86 | |
| 2016 | 57 | |
| 2015 | 42 | |
| 2014 | 47 | |
| 2013 | 49 | |
| 2012 | 61 | |
| 2011 | 41 | |
| 2010 | 50 | |
| 2009 | 45 | |
| 2008 | 45 | |
| 2007 | 47 | |
| 2006 | 29 | |
| 2005 | 42 | |
| 2004 | 26 | |
| 2003 | 11 | |
| 2002 | 14 | |
| 2001 | 9 | |
| 2000 | 10 | |
| 1999 | 4 | |
| 1998 | 5 | |
| 1997 | 5 | |
| 1996 | 8 | |
| 1995 | 5 | |
| 1994 | 1 | |
| 1993 | 5 | |
| 1992 | 3 | |
| 1991 | 2 | |
| 1990 | 1 | |
| 1989 | 1 | |
| 1988 | 1 | |
| 1987 | 1 | |
| 1986 | 2 | |
| 1985 | 1 | |
| 1983 | 1 | |
| 1981 | 1 | |
| 1979 | 1 | |
| 1968 | 1 | |
| 1961 | 1 |
Counts the 1,459 studies with a usable publication date. The library is a large sample of published work, not a complete index, so these counts describe the library, not the whole field.
Other subjects in the library
- Getting a diagnosis
- Biomarkers
- Clinical trials
- Prevention and risk
- Caregiving
- How common it is
- Costs and economics
- Genetics
- Laboratory science
- Disease mechanisms
- Vascular contributions
- Prevention trials
- Clinical safety
- Health systems and care delivery
- End-of-life care
- Risk factors
- Digital health tools
- Treatments
- Disparities
- Mild cognitive impairment
- Risk genes beyond APOE
- TREM2 and immune genetics
- Cognitive tests and assessment
- Lewy body dementia
- Down syndrome and Alzheimer's
- Long-term cohort studies
- Inflammation and the immune system
- Tau biomarkers
- Brain tissue and pathology
- Drug development
- Hippocampus size on brain scans