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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 2,351–2,375 of 27,380 studies, newest first · page 95 of 1096.

December 2025 25

  1. 2025-12-01

    Identification of candidate serum protein biomarkers in Down's syndrome dementia

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: MOLDI-MS identified eighty-five proteins represented by multiple tryptic peptides, twenty-five of which showed significant differences between DS and controls, confirmed by WB and ELISA analysis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2025-12-01

    DIAGNOSTIC APPROCH ON ALZHEIMER'S DISEASE

    ✓ Peer-reviewed Down syndrome and Alzheimer's World Journal of Pharmacy and Pharmaceutical Sciences

    Key finding: This disease starts after the age of 55-60 but in down syndrome patients it starts earlier at the age of 40-50. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2025-12-01

    DIAGNOSTIC APPROCH ON ALZHEIMER'S DISEASE

    ✓ Peer-reviewed Down syndrome and Alzheimer's World Journal of Pharmacy and Pharmaceutical Sciences

    Key finding: This disease starts after the age of 55-60 but in down syndrome patients it starts earlier at the age of 40-50. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2025-12-01

    Distinct Sensitivity of MRI Versus [ 18 F]FDG‐PET To Detect Cerebral Changes Across the Alzheimer's Continuum in Down Syndrome: A Multimodal Imaging Study

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: Amyloid pathology in aDS individuals is linked to frontal‐predominant atrophy without clear hypometabolism. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2025-12-01

    Correlating antemortem amyloid PET burden, postmortem MRI volumes, with neuropathological measures: Insights from Down syndrome and Alzheimer's disease cohorts

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: The ABC-DS cohort showed similar Aβ PET burden but had a lower prevalence of ApoE4 carriers, younger age at clinical diagnosis and autopsy, shorter PET-autopsy interval, smaller amygdala and hippocampal volumes, more advanced CERAD scores, and no atherosclerosis compared to ADRC cohort (Figure 1). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2025-12-01

    Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: There was a significant interaction between OSA and diagnosis for within- and between-DMN FC (p-values<0.05). +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2025-12-01

    Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: We observed higher within‐ and between‐DMN FC in the CS‐OSA compared to the CI‐OSA group; however, this difference was not observed between the CS‐nonOSA and CI‐nonOSA groups. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2025-12-01

    Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: PSMD was more strongly associated with age in DS (rho=0.56; p <0.001) than in HC (rho=0.38, p <0.001; Figure 1A), with regression lines starting to diverge at age 42. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2025-12-01

    Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: In DS, PSMD changed approximately 10‐15 years before the onset of AD symptoms and linearly increased with AD clinical stages, AD pathology, and SVD metrics. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2025-12-01

    Mild premorbid intellectual impairment as a resilience factor in Down syndrome associated Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: Participant and visit numbers varied by measure, with 455 participants evaluated over 1178 data points. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2025-12-01

    Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: Understanding the distribution of SV2A in DS will provide insight on changes to synaptic density in populations with accelerated AD neuropathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2025-12-01

    Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: Understanding the distribution of SV2A in DS will provide insight on changes to synaptic density in populations with accelerated AD neuropathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2025-12-01

    Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: = 49.17) had a higher incidence of psychotic disorder (p = .028) compared to non-progressors and progressors. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2025-12-01

    Life Stress and Dementia Risk in Adults with Down Syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Innovation in Aging

    Key finding: We found that a higher baseline sum of stress events was associated with greater risk of conversion from baseline stable cognition to mild cognitive impairment (MCI) or dementia at follow up, even when controlling for age, sex, premorbid level of intellectual disability, site, clinical latency between assessments, and the presence of anxiety or depression (odds ratio = 1.53, p = 0.021). +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2025-12-01

    Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD)

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: During alteplase administration, the patient experienced clinical deterioration. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2025-12-01

    The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI): Ten Years of Progress in Understanding Alzheimer's in Down Syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: The DABNI cohort included 1,135 participants with a mean age of 42.82 years (SD = 11.56), 46.3% of whom are female. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2025-12-01

    Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: In partial correlations adjusted for age, there was a significant positive association between the cardiovascular composite (r = .156, p = .016) and resistance score; higher cardiovascular composite was associated with greater than expected Aβ for age. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2025-12-01

    Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

    Key finding: Iron storage proteins and lipid peroxidation were increased in prefrontal cortex, but not in the cerebellum. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2025-12-01

    Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project

    ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

    Key finding: Among 160 centenarians, 63.7% did not meet the PCFP criteria and were classified as having dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2025-12-01

    Life Course Modifiable Risk Factors of Dementia: Replicating the 2024 Lancet Commission Model in a Single Longitudinal Cohort

    ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

    Key finding: When risk factors were evaluated independently, we found less early-life education, mid-life hearing loss and diabetes, and late-life social isolation and visual loss associated with increased odds for dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2025-12-01

    Type 2 Diabetes Mellitus, Cognitive Performance, and Incident Dementia; Identifying Mediating Pathways and Biomarkers From the Plasma Proteome

    ✓ Peer-reviewed Risk factors Journal of Neurochemistry

    Key finding: Type 2 diabetes mellitus (T2DM) is associated with poorer cognitive performance and increased dementia risk. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2025-12-01

    Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study

    ✓ Peer-reviewed Risk factors The Lancet Healthy Longevity

    Key finding: Between Sept 1, 2017, and Feb 28, 2019, 19 403 individuals were invited to participate and 9745 participants (1525 with dementia, 8220 without dementia) were included. 4445 (45·6%) of 9745 participants were male and 5300 (54·4%) were female. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2025-12-01

    Enhancing Dementia Risk Prediction with Heart Rate and Machine Learning in the Canadian Longitudinal Study on Aging (CLSA)

    ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia

    Key finding: Among the 18,013 participants with complete data for analysis, 516 (2.86%) exhibited cognitive impairment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2025-12-01

    A Smart RFID-Driven System for Dementia Patient Tracking: A Machine Learning Approach for Monitoring and Localization

    ✓ Peer-reviewed Digital health tools International Journal of Technology

    Key finding: The global increase in the elderly population, which is expected to reach 2.1 billion by 2050, has highlighted the need for reliable monitoring systems to assist elderly individuals, especially those with dementia.

    Full summary, score breakdown and related studies → Original source

  25. 2025-12-01

    Metabolomic Signatures and Machine Learning Models for Distinguishing Alzheimer's Disease and Dementia with Lewy Bodies

    ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia

    Key finding: AD patients exhibited a significantly higher prevalence of APOE e3/e4 and e4/e4 genotypes compared to DLB and HC (p <0.001). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →