Newest studies

Lecanemab in DIAD: 6‐Month Amyloid PET Results from the DIAN‐TU‐001 Trial

48/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia

Key finding: Lecanemab reduced amyloid PET in symptomatic participants with DIAD at Week 24. +2 more findings

• Treatments
• Clinical Trials
• Brain Scans

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Validation of blood biomarkers for Alzheimer Disease in Thai Cohort

44/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia

Key finding: Plasma biomarkers showed promising diagnostic performances and potential clinical usefulness in diagnosing dementia. +1 more finding

• Biomarkers

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Development of language composites for enhanced sensitivity to multiple plasma biomarkers

50/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia

Key finding: The empirical language composite showed superior and consistent sensitivity (faster decline rate) with all three biomarkers. +4 more findings

• Biomarkers

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Can longitudinal measures of plasma biomarkers track disease progression in early Alzheimer´s Disease?

54/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia

Key finding: In the whole cohort, p ‐tau217, NfL, GFAP and p ‐tau181 were significantly increased over time showing more accelerated increase in Aβ+ than Aβ‐ participants. +3 more findings

• Biomarkers

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Association of Neighborhood‐Level Disadvantage with Cerebrovascular Disease Neuropathology in a National Sample of Brain Donors

45/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: We found that ∼25% of donors lived in high deprivation contexts, 52% had at least one incidence of CVD, and the cohort identified as .05). +2 more findings

• Brain Biology

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Neighborhood disadvantage, systemic inflammation, and tau pathology: a link between social determinants of health and Alzheimer's disease risk

41/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Higher ADI was significantly associated with increased CRP (r=0.469, p = 0.002) and TREM-1 (r=0.316, p = 0.047). +4 more findings

• Health Equity
• Brain Biology

Full summary, score breakdown and related studies → Original source

WHERE CARE FALLS SHORT: MAPPING THE SUPPLY–DEMAND GAP IN ADRD CARE ACROSS AN AGING UNITED STATES

30/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: These findings highlight a persistent spatial mismatch between population needs and care infrastructure. +1 more finding

• Care Services
• Health Equity

Full summary, score breakdown and related studies → Original source

Inflammation and Cognition: The Moderating Role of Neighborhood Disadvantage

32/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: Specifically, higher inflammation was associated with worse processing speed (B = -0.01; p < .05) and working memory (B = 8323.66; p < .1) only among those from more disadvantaged neighborhoods. +2 more findings

• Health Equity
• Brain Biology

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Neighborhood Disadvantage and Cognitive Function: The Moderating Role of Self-reported Loneliness

32/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: Overall, our findings suggest that greater neighborhood disadvantage may influence select domains of memory, and that one’s self-reported loneliness may influence how this relationship manifests. +3 more findings

• Lifestyle
• Health Equity

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Socioeconomic deprivation and medical comorbidity burden associations with clinicopathologic characteristics in an ethnoracially diverse Alzheimer's disease autopsy series

40/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The table shows a comparative analysis stratified by young-onset AD (YOAD, onset <65 years) and late-onset AD (LOAD, onset ≥65 years). +4 more findings

• Brain Biology
• Health Equity

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Characterization of Hispanic, African American, and non‐Hispanic White individuals living in disadvantage neighborhoods: the HABS‐HD Study

42/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: In the whole sample, significant differences between ethnicities were found in demographic, SE, psychological, and health variables. +4 more findings

• Health Equity
• Risk Factors

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Multilevel and Multidimensional Features of Socioeconomic Status and Cognitive Function in Older Adulthood: Findings from the IGNITE Study

41/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Lower objective SES was associated with poorer performance on all cognitive domains: episodic memory (β = 0.115, p = 0.003), executive function (β = 0.210, p 0.05). +4 more findings

• Health Equity

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“Who are you calling rural?”: An Analysis of Classification Codes Evaluating Disadvantage in Rural Regions and their Correlation in an Appalachian Kentucky Cohort

38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Proportions defined as living in a rural or disadvantaged area varied by classification, ranging from 13% to 27% of the cohort. +4 more findings

• Health Equity

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Relationships among cognitive function, ADRD risk and sociodemographic characteristics in a diverse rural setting in south‐central Florida

37/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: (n = 399) have completed the first follow-up assessments, including MoCA, mCAIDE, memory self-report, demographic information. +4 more findings

• Health Equity

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Impact of outcome misclassification in Medicare claims on geographic differences in ADRD prevalence in Central Appalachia

34/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: All non-differential bias scenarios were biased toward the null (Table 1). +4 more findings

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White Matter Hyperintensities Predict Driving Behavior Changes in Preclinical Alzheimer’s Disease

47/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Our study included 74,275 weeks of driving data (2015-2024, average follow-up 6.1 years). +4 more findings

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Shelter-in-Place Policies, Proximity, and Changes in Caregiving for Older Adults During the COVID-19 Pandemic

36/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: The study sample was NHATS respondents who needed assistance with activities of daily living (ADL) or instrumental activities of daily living (IADL), and who did not live with a spouse (N = 512). +2 more findings

• Caregiving
• Policy

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Associations between systemic inflammation, neighborhood tree canopy, and white matter hyperintensities: The Healthy Brain Initiative

38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Participants were 68.7±9.3 years old; 70% were female; 8% identified as Black, 89% White, as 3% other racial group; and 14% identified as Hispanic. +4 more findings

• Brain Biology

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Association of Neighborhood‐Level Disadvantage with Antemortem MRI Brain Volumes in a Multi‐site Brain Bank Donor Cohort

50/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: A significant ADI × dementia interaction was observed for global atrophy (p = .005) and several other outcomes. +4 more findings

• Brain Scans

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Community-level Alzheimer’s Disease or Related Dementia’s 65+ Prevalence in Five New England States

31/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: An estimated two thirds of people living with Alzheimer’s disease or related dementias (ADRD) live and are cared for at home.

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Does Neighborhood Disadvantage Moderate the Relationship between Apolipoprotein E Status and Cognitive Functioning?

39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Environmental factors like neighborhood disadvantage are also associated with cognitive decline, however, few studies have integrated this with APOE research. +4 more findings

• Genetics
• Health Equity

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Hearing Impairment, Hearing Aid Use, and Cognitive Outcomes in Older Adults: A Cross‐Sectional Study

44/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Participants with impaired hearing (n = 179) were older (73.9 vs. 71.4 years, p <0.001), often male (61.5% vs. 36.5%, p <0.001), and had lower cognitive scores than normal-hearing individuals (n = 241). +4 more findings

• Lifestyle

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Residential segregation exacerbates the effects of cardiovascular disease on cognition in Black older adults

34/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: In highly segregated counties, Black older adults with elevated CVD demonstrated worse memory than those with lower CVD; in less segregated counties, memory levels did not differ by CVD. +3 more findings

• Risk Factors
• Health Equity

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The America I Know Could Use a Good Cry: Impact of State and Civilian‐Perpetrated Racial Violence on Cognitive Health

35/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Participants racialized as Black living in a county with a history of lynching, disproportionate police killings, and disproportionate jail and prison incarceration were 2.8 (95%CI [-0.003, 5.834]) times more likely to have at least one incident of cognitive impairment between 2008-2020 compared to participants racialized as Black living in a county with a history of lynching and disproportionate police killings but not disproportionate incarceration. +2 more findings

• Health Equity

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Using real world data to visualize longitudinal modifiable dementia risk factors in the community through an online interactive map

49/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: There were observable geographic variations in education (range 13.4-16.2 years, Figure 1), age (range 66.7-72.4 years) and severable modifiable risk factors for dementia across Tasmania, Australia. +4 more findings

• Risk Factors
• Prevention
• Digital Tools

Full summary, score breakdown and related studies → Original source