Newest studies

Clinical course and serum amyloid β levels in elderly patients with major depressive disorder

41/100 ✓ Peer-reviewed Biomarkers Journal of affective disorders

Key finding: The analysis revealed decreased Aβ42 levels and increased Aβ42/40 ratios in elderly patients with depression at admission compared with healthy subjects. +4 more findings

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Catastrophic health expenditure among Chinese adults living alone with cognitive impairment: findings from the CHARLS

54/100 ✓ Peer-reviewed Health systems and care delivery BMC Geriatrics

Key finding: In comparison with participants living with others and with normal cognition, those adults living alone with cognitive impairment reported a higher percentage of catastrophic health expenditure (19.5% vs. 11.8%, respectively, P < 0.001). +4 more findings

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Early diagnosis of Alzheimer's disease using machine learning: a multi-diagnostic, generalizable approach

57/100 ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

Key finding: In sum, we present a diagnostic tool for MCI and AD trained using baseline scans and a follow-up diagnosis regardless of progression, which is multi-diagnostic, generalizable across independent data sources and acquisition protocols, and with transparently reported performance. +4 more findings

• Digital Tools
• Diagnosis

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Prevalence of dementia in Latin America and Caribbean countries: Systematic review and meta-analyses exploring age, sex, rurality, and education as possible determinants

60/100 ✓ Peer-reviewed Disparities Ageing research reviews

Key finding: Our findings suggest a high global dementia prevalence in LAC countries and an unequal burden of dementia for women, lower-educated, and rural residents. +3 more findings

• Health Equity

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End-of-Life Costs of Cancer Patients With Alzheimer's Disease and Related Dementias in the U.S

57/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Eighty six thousand three hundred ninety-six beneficiaries were included (43,198 beneficiaries with ADRD and 43,198 beneficiaries without ADRD). +4 more findings

• End-of-Life Care
• Policy

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α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation

41/100 ✓ Peer-reviewed Vascular contributions Cellular and molecular life sciences : CMLS

Key finding: We found that novel functions of ENO1 included interacting with Aβ and inhibiting its fibril formation, disrupting Aβ fibrils, and weakening the cytotoxic effects of these fibrils via proteolytic degradation of Aβ peptide. +2 more findings

• Brain Biology

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Trajectories of sleep duration and timing before dementia: a 14-year follow-up study

55/100 ✓ Peer-reviewed Risk factors Age and ageing

Key finding: long baseline nighttime and 24-h sleep durations (≥9 h) as well as being persistent or becoming long sleepers during follow-up were associated with dementia incidence. +3 more findings

• Lifestyle

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Alzheimer's polygenic hazard score in SuperAgers: SuperGenes or SuperResilience?

52/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia (New York, N. Y.)

Key finding: A total of 37 SuperAgers (73% female, mean [standard deviation] 82.7 [2.8] years old) and 35 controls (54% female, 83.7 [4.3] years old) were included. +4 more findings

• Genetics

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Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults

51/100 ✓ Peer-reviewed Inflammation and the immune system Neurology

Key finding: We investigated whether β-amyloid, cortical thickness in medial temporal lobe structures, neuroinflammation, and sociodemographic factors were associated with greater anxious-depressive symptoms during the COVID-19 confinement. +4 more findings

• Biomarkers

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Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study

54/100 ✓ Peer-reviewed Long-term cohort studies BMC geriatrics

Key finding: Alzheimer's disease (AD) is the most frequently occurring type of dementia. +3 more findings

• Genetics
• Lifestyle

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Supramolecular organizing centers at the interface of inflammation and neurodegeneration

41/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in immunology

Key finding: These deposits are both directly toxic to neurons, invoking loss of cell connectivity and cell death, and recognized by innate sensors that upon activation release neurotoxic cytokines, chemokines, and various reactive species. +4 more findings

• Brain Biology
• Treatments

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Discrepancy between self-reported and objective sleep duration among dementia caregivers and noncaregivers

61/100 ✓ Peer-reviewed Risk factors Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Key finding: Caregivers showed a greater discrepancy in sleep duration than did noncaregivers (-0.46 hour vs 0.22 hour, respectively; P = .003). +4 more findings

• Lifestyle
• Caregiving

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Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells

41/100 ✓ Peer-reviewed TREM2 and immune genetics Glia

Key finding: The receptor Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is associated with several neurodegenerative diseases including Alzheimer's Disease and TREM2 stimulation represents a novel therapeutic opportunity. +1 more finding

• Treatments

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Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer's disease

55/100 ✓ Peer-reviewed Genetics BMC medical genomics

Key finding: We propose a novel method to identify disease-related genetic variants enriched by imaging endophenotypes, which are the imaging traits associated with both genetic factors and disease status. +4 more findings

• Genetics
• Brain Scans

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APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

48/100 ✓ Peer-reviewed Genetics Signal transduction and targeted therapy

Key finding: Although APOE has recently been associated with increased susceptibility to infections of several viruses, whether and how APOE and its isoforms affect SARS-CoV-2 infection remains unclear. +1 more finding

• Genetics
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Equitability of Depression Screening After Implementation of General Adult Screening in Primary Care

66/100 ✓ Peer-reviewed Digital health tools JAMA network open

Key finding: Men, racial and ethnic minority individuals, older adults, and those with language barriers are at increased risk for undertreatment of depression. +4 more findings

• Care Services
• Diagnosis
• Health Equity

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Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease

43/100 ✓ Peer-reviewed Drug development Neural regeneration research

Key finding: Recently, it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and, more importantly, that downregulation of tau partially reverses transcriptional perturbations. +1 more finding

• Brain Biology

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Aducanumab for Alzheimer's Disease: Summarized Data From EMERGE, ENGAGE, and PRIME Studies

40/100 ✓ Peer-reviewed Treatments The Senior care pharmacist

Key finding: Based on the data to date, it is difficult to accurately assess the role of aducanumab in patients with MCI or mild AD. +2 more findings

• Treatments
• Clinical Trials
• Side Effects

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Disease-associated oligodendrocyte responses across neurodegenerative diseases

67/100 ✓ Peer-reviewed Genetics Cell reports

Key finding: We identify three distinct activation states of oligodendrocytes from single-cell RNA sequencing (RNA-seq) of mouse models of Alzheimer's disease (AD) and multiple sclerosis (MS): DA1 (disease-associated1, associated with immunogenic genes), DA2 (disease-associated2, associated with genes influencing survival), and IFN (associated with interferon response genes).

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Quality and safety indicators for home care recipients in Australia: development and cross-sectional analyses

48/100 ✓ Peer-reviewed Risk factors BMJ Open

Key finding: A comprehensive outcome monitoring system to monitor the quality and safety of care and variation for HCP recipients was developed.

• Side Effects
• Care Services

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Predictors of returning home after hip fracture: a prospective cohort study using the UK National Hip Fracture Database (NHFD)

55/100 ✓ Peer-reviewed Risk factors Age and Ageing

Key finding: analysis of returning home at discharge included 87,797 patients; 57,104 (65%) were discharged home. +4 more findings

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Vitamin D and brain health: an observational and Mendelian randomization study

55/100 ✓ Peer-reviewed Long-term cohort studies The American journal of clinical nutrition

Key finding: Higher vitamin D status has been suggested to have beneficial effects on the brain. +3 more findings

• Lifestyle

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Longitudinal Clinical and Cognitive Changes Along the Alzheimer Disease Continuum in Down Syndrome

66/100 ✓ Peer-reviewed Down syndrome and Alzheimer's JAMA network open

Key finding: At baseline, there were 436 asymptomatic individuals, 69 patients with prodromal AD, and 127 with AD dementia. +1 more finding

• Down Syndrome

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Association of APOE Genotypes and Chronic Traumatic Encephalopathy

63/100 ✓ Peer-reviewed Disparities JAMA neurology

Key finding: Limited evidence suggests that the APOEε4 allele may confer risk for CTE, but previous studies were small with limited scope. +4 more findings

• Genetics
• Other Dementias
• Brain Biology

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Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline

67/100 ✓ Peer-reviewed Disparities Brain : a journal of neurology

Key finding: Accumulating data suggest that cerebrovascular disease contributes to Alzheimer's disease pathophysiology and progression toward dementia. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source