Newest studies

Disproportionately Elevated Sulcal Index (DESI): An automatically driven index representing disproportionate subarachnoid space enlargement in brain MRI scans

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials medRxiv

Key finding: DESI is a robust, fully automated MRI biomarker that sensitively detects CSF redistribution characteristic of DESH in iNPH.

• Clinical Trials
• Biomarkers
• Brain Scans

Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinsonian Disorders in Patients with Obesity

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: Among adults with obesity or overweight with a weight related condition, there was no difference in the risk of PD or Parkinsonian disorders between GLP-1 RA users and non-users. +3 more findings

• Risk Factors
• Treatments
• Other Dementias

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition

43/100 ✓ Peer-reviewed TREM2 and immune genetics Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: Cellular assays demonstrated that As48 functions as a TREM2 agonist, activating SYK phosphorylation and enhancing microglial phagocytosis. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Protective ApoE variants support neuronal function by effluxing oxidized phospholipids

45/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Our findings reveal how ApoE2 and ApoE3Ch help protect neurons from neurodegeneration.

• Genetics

Full summary, score breakdown and related studies → Original source

Physical and Cognitive Activities and Trajectories of AD Neuroimaging Biomarkers

50/100 ✓ Peer-reviewed Disease mechanisms Neurology

Key finding: Physical activity was associated with less synaptic dysfunction and cognitive activity with less synaptic dysfunction and lower amyloid burden over time, albeit effect sizes were small. +1 more finding

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism

36/100 ✓ Peer-reviewed Brain tissue and pathology Acta Neuropathologica Communications

Key finding: Two FDA-approved drugs used to treat ALS, edaravone and riluzole, were examined in these models and revealed that edaravone, but not riluzole, was effective in rescuing motor deficits associated with cytoplasmic TDP-43 expression and, to a lesser extent, ALS-linked mutant TDP-43. +1 more finding

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Enfermedad de Alzheimer en la mujer

25/100 ✓ Peer-reviewed Risk genes beyond APOE Acta Médica Colombiana

Key finding: La enfermedad de Alzheimer (EA) fue descrita por primera vez en una mujer, Augusta D, cuyo caso reveló las características neuropatológicas clásicas de placas amiloides y ovillos neurofibrilares. +4 more findings

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Beyond the Clock: Exploring Multimodal Behavior Markers of Mild Cognitive Impairment in Older Adults during Clock Drawing Test

38/100 ✓ Peer-reviewed Mild cognitive impairment Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies

Key finding: External validation with 76 additional participants demonstrated good generalizability (AUC: 0.86). +1 more finding

• Early Stage

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Continuous Glucose Monitoring in Insulin-Treated Older Adults With Diabetes and Alzheimer Disease and Related Dementias

54/100 ✓ Peer-reviewed Risk factors JAMA Network Open

Key finding: In this cohort of 2022 insulin-treated older adults with diabetes and ADRD (1011 CGM users and 1011 SMBG users; mean [SD] age, 76.4 [6.7] years; 1133 female [56.0%]), CGM use was significantly associated with lower risk of all-cause hospitalization (hazard ratio [HR], 0.86; 95% CI, 0.76-0.96) and mortality (HR, 0.57; 95% CI, 0.48-0.67) compared with SMBG use. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Clinical and pathologic correlations of machine learning quantification of Aβ deposits across 3 brain regions of decedents with Alzheimer disease

43/100 ✓ Peer-reviewed Genetics Journal of Neuropathology & Experimental Neurology

Key finding: Following log transformation, mixed-effects modeling revealed the parietal cortex had the highest cored plaque densities (P < .001); the temporal cortex had the highest diffuse plaque (P < .001); CAA showed no regional differences. +3 more findings

• Brain Biology
• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

Plasma pTau-181 Exhibits Flat Longitudinal Trajectories and Weak Cognitive Correlation in UK Biobank: Implications for Anti-Tau Antibody Trial Failures

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: Plasma pTau-181 demonstrates flat or declining longitudinal trajectories and minimal cognitive correlation, suggesting tau is a static biomarker rather than a dynamic therapeutic target in mid-to-late adulthood. +1 more finding

• Biomarkers
• Treatments
• Clinical Trials

Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging

46/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Among the natural extracts tested, PanQ emerged as the most effective for increasing the active CatB isoform in correspondence with enhanced levels of synaptic proteins and the autophagy marker LC3-II. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Reframing TDP-43 in Alzheimer's disease: From co-pathology to neurovascular culprit

46/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: HIGHLIGHTS: Transactive response (TAR) DNA-binding protein 43 kDa (TDP-43) may act as a driver of neurovascular dysfunction in Alzheimer's disease (AD). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The evolving therapeutic landscape of dementia with Lewy bodies

46/100 ✓ Peer-reviewed Brain tissue and pathology The Lancet. Neurology

Key finding: The disorder causes high morbidity, is associated with high caregiver burden, and can result in considerable health-care costs.

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models

43/100 ✓ Peer-reviewed Inflammation and the immune system Journal of leukocyte biology

Key finding: In the AD brain, microglial exposure to pathological amyloid β (Aβ42) and tau peptide aggregates results in an NLRP3 inflammasome-activated proinflammatory response that ranges from mild to severe. +2 more findings

• Brain Biology

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Polygenic risk score predicts pathologically confirmed cerebral amyloid angiopathy

52/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: CAA-PRS was significantly associated with pathological CAA (OR = 1.766, p < 0.001), with an AUC of 0.783 overall and 0.766 (OR = 1.780, p = 0.002) in those with high amyloid burden. +4 more findings

Full summary, score breakdown and related studies → Original source

Single-cell landscape of sex-specific drivers of Alzheimer's disease

63/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Nine female-specific associations were identified and replicated, involving ADGRV1, OR3A3, IFI27L1, LYRM1, STAP2, TSTD2, PDYN, and TMEM50B. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Enhancing diagnostic precision in Alzheimer's disease: Impact of comorbidities on blood biomarkers for clinical integration

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma biomarkers were associated with comorbidities and metabolites such as estimated glomerular filtration rate, homocysteine, and high-density lipoprotein. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Combined use of plasma p-tau217, NfL, and GFAP predicts domain-specific cognitive decline in cognitively unimpaired and MCI individuals

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Among all participants, high p-tau217 alone [p-tau217(+)NfL(-)GFAP(-)] was associated with a steeper decline in episodic/semantic memory and processing speed compared to the all-low group (p ≤ 0.02). +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

AD-related plasma biomarkers in centenarians: links to cognition and neuropathology

70/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Cognition ranged from high to early cognitive decline (median Mini-Mental State Examination [MMSE] score = 26). +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Lactate metabolic clearance rate did not differ between CH and CI subjects (p = 0.988). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain-Derived Tau Across the Biochemical Spectrum of Alzheimer's Disease

59/100 ✓ Peer-reviewed Biomarkers Journal of neurochemistry

Key finding: Plasma concentrations of all p-tau isoforms were significantly elevated in both Possible AD and Probable AD groups compared to Controls (p < 0.001). +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Worse overall and local LC-EC integrity, indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), was related to elevated concentrations of plasma phosphorylated tau 181 (p-tau181), p-tau217, and glial fibrillary acidic protein (GFAP). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

False positive plasma p-tau217 results associated with heterophilic antibody interference: A potential clinical pitfall

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In 14 of the 15 suspected HAb cases, HBT treatment greatly reduced measured p-tau217 concentrations. and in one of three specimens selected for further investigation, reduced Aβ42 concentrations PEG precipitation in the three selected samples also reduced p-tau217 concentrations, while serial dilution yielded mixed effects. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

APOE ɛ4 carriership determines a faster plasma p-tau217 progression in Aβ-positive individuals

73/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In TRIAD, ALZpath p-tau217 (β = 0.45, p = 0.02) and p-tau217+Janssen (β = 0.67, p = 0.002), and in ADNI p-tau217 (β = 0.90, p = 0.002) increased faster in A+E4+. +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source