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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Down syndrome and Alzheimer's

Topic: Risk, prevention and care in population studies

= 49.17) had a higher incidence of psychotic disorder (p = .028) compared to non-progressors and progressors. Both atypical groups had lower incidence of COVID infection (p = .046), but still had high amyloid load (M=30.50CL and 48.02CL, respectively). In our sample of adults with DS and MCI-DS, 31.6% did not progress to dementia despite having high levels of amyloid PET. Those whose decline plateaued had more medical conditions and life stressors. Those with temporary decline had more psychiatric problems. Primary care physicians need to understand which reversible or treatable factors are most likely to lead to a misdiagnosis of prodromal AD and address them accordingly.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Valencia, D. K., Silverman, W. P., Hartley, S. L., Zaman, S. H., Brickman, A., Lai, F. Y., et al. (2025). Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome. Alzheimer s & Dementia. https://doi.org/10.1002/alz70857_105703

Vancouver

Valencia DK, Silverman WP, Hartley SL, Zaman SH, Brickman A, Lai FY, et al. Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome. Alzheimer s & Dementia. 2025. doi:10.1002/alz70857_105703. PMID: 41449092.

BibTeX

@article{valencia2025-41449092,
  author  = {Valencia, Diana K. and Silverman, Wayne P. and Hartley, Sigan L. and Zaman, Shahid H. and Brickman, Adam and Lai, Florence Y. and Mapstone, Mark E. and Krinsky‐McHale, Sharon J. and others},
  title   = {{Factors Associated with Atypical Cognitive Trajectories in Older Adults with Down Syndrome}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70857_105703},
  pmid    = {41449092},
  url     = {https://doi.org/10.1002/alz70857_105703}
}

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Key findings

= 49.17) had a higher incidence of psychotic disorder (p = .028) compared to non-progressors and progressors.
Both atypical groups had lower incidence of COVID infection (p = .046), but still had high amyloid load (M=30.50CL and 48.02CL, respectively).
In our sample of adults with DS and MCI-DS, 31.6% did not progress to dementia despite having high levels of amyloid PET.
Those whose decline plateaued had more medical conditions and life stressors.
Those with temporary decline had more psychiatric problems.

Why it matters

Among adults with Down syndrome and mild cognitive impairment, 31.6% did not progress to dementia despite high amyloid levels, and those with plateaued decline had more medical conditions and life stressors. The findings suggest that reversible factors can lead to misdiagnosis of prodromal Alzheimer's, and primary care physicians should address them.

Study details

Study designlongitudinal study
Effect size31.6%
Evidence strengthModerate

How this study scored 45/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Christy L. Hom: h-index 15 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 9 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41449092)
Free to read	2 / 2	Free to read
Total	45 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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