Newest studies

Performance of plasma biomarkers for diagnosis and prediction of dementia in a Brazilian cohort

66/100 ✓ Peer-reviewed How common it is Nature Communications

Key finding: Plasma Tau, Aβ40, Aβ42, NfL, GFAP, pTau231, pTau181 and pTau217 were measured on the SIMOA HD-X platform. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Financial difficulties and well-being among caregivers of persons with severe dementia

47/100 ✓ Peer-reviewed Caregiving Aging & Mental Health

Key finding: We also found that greater use of emotion-focused coping and deriving greater gains in caregiving mitigated the negative association between caregiver financial difficulty and their distress and perception of PwSDs' well-being. +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

Determinants of dementia risk among older adults with probable sarcopenia and sarcopenia

40/100 ✓ Peer-reviewed Getting a diagnosis BMC Public Health

Key finding: Probable sarcopenia subjects with dementia were older (68.5(7.8) years old) as compared to those without dementia (66.0(6.0) years old). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Longitudinal, Bidirectional Association between Gait Speed and Cognitive Function in Community-Dwelling Older Adults without Dementia

54/100 ✓ Peer-reviewed Getting a diagnosis Journal of the American Medical Directors Association

Key finding: This study found a reciprocal association between gait speed and global or domain-specific cognition. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Automatic mandibular third molar and mandibular canal relationship determination based on deep learning models for preoperative risk reduction

41/100 ✓ Peer-reviewed Prevention and risk Clinical Oral Investigations

Key finding: MobileNet achieved the highest overall performance, with an accuracy of 99.44%. +4 more findings

• Prevention
• Digital Tools

Full summary, score breakdown and related studies → Original source

Understanding Susceptibility to Breast Cancer: From Risk Factors to Prevention Strategies

48/100 ✓ Peer-reviewed Prevention and risk International Journal of Molecular Sciences

Key finding: Current chemoprevention strategies primarily depend on selective estrogen receptor modulators (SERMs), including tamoxifen and raloxifene, which have demonstrated efficacy in reducing the incidence of estrogen receptor-positive breast cancer but remain underutilized due to adverse effects.

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Escitalopram for agitation in Alzheimer's dementia: a randomized controlled phase 3 trial

74/100 ✓ Peer-reviewed Treatments Nature Medicine

Key finding: Citalopram is effective in treating agitation in Alzheimer's dementia (AD), but it is associated with cognitive and cardiac risks, likely due to its R-enantiomer. +4 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

A mindfulness-based multicomponent caregiver intervention (PAACC): objectives, study design, and cohort description

82/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia (New York, N. Y.)

Key finding: Baseline assessments were conducted on 133 family caregivers of veterans living with dementia. +4 more findings

• Caregiving
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Heart Failure, Dementia is Associated with Increased Stroke Severity, in-Hospital Mortality and Complications

42/100 ✓ Peer-reviewed Vascular contributions ESC Heart Failure

Key finding: Patients in this study were from the China Stroke Center Alliance database. +4 more findings

• Risk Factors
• Care Services

Full summary, score breakdown and related studies → Original source

Continued Use of Cholinesterase Inhibitors and Memantine in Hospice

51/100 ✓ Peer-reviewed End-of-life care JAMA Internal Medicine

Key finding: This cohort study examines the use of cholinesterase inhibitors and memantine among older adults with dementia after admission into hospice care despite the medications’ limited clinical benefit following enrollment into hospice.

• Treatments
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Change in Fall Status of Older People With Dementia and Caregiving Difficulties: Moderation Effects of Living Arrangements

37/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

Key finding: For co-residing care partners, high (p = 0.001), increased (p = 0.001), and decreased (p = 0.001) fall frequency over 2 years was significantly associated with emotional difficulties. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

(−)‐Epicatechin Rescues Memory Deficits by Activation of Autophagy in a Mouse Model of Tauopathies

34/100 ✓ Peer-reviewed Disease mechanisms MedComm

Key finding: Recent studies have shown that (-)-Epicatechin (Epi), a dietary flavonoid belonging to the flavan-3-ol subgroup, improves blood flow, modulates metabolic profiles, and prevents oxidative damage. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Hypertension and Atrial Fibrillation: A Frontier Review From the AF-SCREEN International Collaboration

48/100 ✓ Peer-reviewed Risk factors Circulation

Key finding: The current evidence suggests that high-risk individuals aged ≥65 years or with treatment-resistant hypertension could benefit from AF screening.

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Trends in Mortality Related to Atrial Fibrillation and Dementia in Older Adults in the United States: A 2000–2020 Analysis

53/100 ✓ Peer-reviewed Disparities Journal of Cardiovascular Electrophysiology

Key finding: A total of 400 103 AF and dementia-related deaths were recorded between 2000 and 2020. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Integrated bioinformatics analysis and biological experiments to identify key immune genes in vascular dementia

44/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Immunology

Key finding: The results of gene set enrichment and gene set variation analyses indicated that immune-related pathways were upregulated in patients with VaD. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction—A Review of Randomized Controlled Trials Published Since January 1996

47/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Previous research has also demonstrated an association between lower plasma homocysteine levels and decreased risk of myocardial infarction, stroke, and venous thromboembolism. +1 more finding

• Prevention
• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration

43/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

Key finding: TREM2, a microglia-specific receptor, is strongly associated with Alzheimer's disease (AD) risk, mediating microglial responses to amyloid pathology critical to AD development. +2 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Intrinsic capacity in patients with dementia with Lewy bodies compared with those with Alzheimer’s disease: A cross-sectional study

53/100 ✓ Peer-reviewed Lewy body dementia The journal of nutrition health & aging

Key finding: A total of 798 patients (154 with probable DLB and 644 with AD) were included, and the mean age was 81.4 years (SD 6.33). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Post-stroke cognitive impairment and dementia research in Southeast Asia: A scoping review

53/100 ✓ Peer-reviewed How common it is Asian Journal of Psychiatry

Key finding: 9118 references were identified, and 103 articles (from 78 studies) published between 1992 and 2024 were included. +4 more findings

Full summary, score breakdown and related studies → Original source

Caregiver Sleep Quality and Depression: The Roles of Dementia Caregiving, Support Availability, and Rural–Urban Contexts

43/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Probable dementia caregiving predicted worse sleep quality, which mediated the relationship with higher depressive symptoms. +4 more findings

• Caregiving
• Lifestyle
• Health Equity

Full summary, score breakdown and related studies → Original source

Loss of excitatory inputs and decreased tonic and evoked activity of locus coeruleus neurons in aged P301S mice

39/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of Disease

Key finding: Tau pathology in the locus coeruleus (LC) is associated with several neurodegenerative conditions including Alzheimer's disease and frontotemporal dementia. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Advanced biomarkers: Beyond amyloid and tau: Emerging non-traditional biomarkers for alzheimer`s diagnosis and progression

41/100 ✓ Peer-reviewed Biomarkers Ageing research reviews

Key finding: Alzheimer's disease (AD) is the most common neurodegenerative disorder that leads to progressive cognitive decline and imposes a significant socio-economic burden.

• Biomarkers
• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Movement disorders associated with acetylcholinesterase inhibitors in Alzheimer's dementia: A systematic review

54/100 ✓ Peer-reviewed Treatments Brain circulation

Key finding: Overall, 74 studies containing 92 cases were found of MDs related to ACHEIs. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?

46/100 ✓ Peer-reviewed Prevention trials GeroScience

Key finding: Emerging evidence suggests that cerebromicrovascular endothelial senescence plays an important role in the pathogenesis of VCI by promoting cerebral blood flow dysregulation, neurovascular uncoupling, blood-brain barrier (BBB) disruption, and the development of cerebral microhemorrhages (CMHs). +2 more findings

• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Cognitive Training and Enrichment Modulates Neural Plasticity and Enhances Cognitive Reserve in Aging Rats

28/100 ✓ Peer-reviewed Prevention trials Experimental Aging Research

Key finding: The Ct group and Ct+ee group performed significantly better than the control group in behavioural tasks and had improved dendrite profiles of DG and basal tree of CA1 region of hippocampus. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source