Newest studies

Centiloids in Amyloid PET: A Practical Guide to Quantitation Interpretation

44/100 ✓ Peer-reviewed Biomarkers Journal of Nuclear Medicine Technology

Key finding: Although visual interpretation remains the clinical standard for amyloid PET, it may be limited in borderline cases and when assessing subtle changes in amyloid burden over time. +4 more findings

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

Effects of peer support interventions for family caregivers of persons with dementia: A systematic review and meta-analysis

59/100 ✓ Peer-reviewed Caregiving Archives of gerontology and geriatrics

Key finding: Peer support interventions suggest beneficial short-term effects on specific caregiver outcomes but lack long-term sustainability. +2 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial

72/100 ✓ Peer-reviewed Clinical trials JAMA

Key finding: Of the 120 participants (mean age, 71.4 [SD, 8.6] years; 55% were female), 93 (77.5%) completed the trial.

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Concurrent Gabapentin and Dihydropyridine Calcium Channel Blocker Use and Risk of Incident Dementia: An Active-Comparator Cohort Study

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: Both classes act on neuronal calcium signaling, raising the question of whether their combined use is associated with greater cognitive risk than gabapentin alone. +4 more findings

• Risk Factors

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Disaggregating Poverty Estimates to Sub-County Level using Small Area Model: Application of EBP

24/100 ✓ Peer-reviewed Risk factors International Journal of Poverty, Investment and Development

Key finding: The results demonstrate similar poverty patterns as per county data findings on Kenya poverty report, 2022. +4 more findings

Full summary, score breakdown and related studies → Original source

Social determinants of brain structure and cognition

41/100 ✓ Peer-reviewed Risk factors Social science & medicine (1982)

Key finding: We investigated whether neighborhood disadvantage, measured by the Area Deprivation Index (ADI), was associated with cognitive performance in older adults and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), and whether structural brain differences explained this relationship. +4 more findings

• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

Additional file 1 of Factors influencing readiness for advance care planning in dementia: a qualitative interview study

32/100 ✓ Peer-reviewed End-of-life care Figshare

Key finding: Interview guides on experiences with advance care planning, factors influencing readiness for advance care planning, and the use of conversation aids among people with dementia, family caregivers, and healthcare professionals. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Additional file 1 of Factors influencing readiness for advance care planning in dementia: a qualitative interview study

41/100 ✓ Peer-reviewed End-of-life care Figshare

Key finding: Interview guides on experiences with advance care planning, factors influencing readiness for advance care planning, and the use of conversation aids among people with dementia, family caregivers, and healthcare professionals. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Additional file 2 of Factors influencing readiness for advance care planning in dementia: a qualitative interview study

41/100 ✓ Peer-reviewed End-of-life care Figshare

Key finding: Coding tree of main categories and specific sub categories describing factors influencing readiness for advance care planning among people with dementia, family caregivers, and healthcare professionals. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Additional file 2 of Factors influencing readiness for advance care planning in dementia: a qualitative interview study

32/100 ✓ Peer-reviewed End-of-life care Figshare

Key finding: Coding tree of main categories and specific sub categories describing factors influencing readiness for advance care planning among people with dementia, family caregivers, and healthcare professionals. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Factors influencing readiness for advance care planning in dementia: a qualitative interview study

32/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: For people with dementia (n = 6), readiness was facilitated by a desire for autonomy. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

39/100 ✓ Peer-reviewed Disease mechanisms Brain Pathology

Key finding: We found selective synaptic loss in the entorhinal cortex (-14%, p = 0.017) and parahippocampal gyrus (-14%, p = 0.021) in AD versus controls. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The yes-no reversal phenomenon: Prevalence and correlates in mild cognitive impairment and dementia due to neurodegenerative, chronic cerebrovascular, and mixed etiologies

44/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease

Key finding: YNR+ and YNR- patients were compared on demographics (i.e., age, sex, education), disease duration (in months), disease severity (i.e., MCI versus dementia), etiology and total and subscale-/item-level Mini-Mental State Examination (MMSE) scores. +2 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Measurement differences in the Harmonized Cognitive Assessment Protocol across ethnicity and language in the United States

39/100 ✓ Peer-reviewed Getting a diagnosis Neuropsychology

Key finding: We observed measurement differences in the HCAP across H/L and NHW older adults for the memory, language, executive functioning, and orientation, but not visuospatial, domains. +4 more findings

• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

Recombinant zoster vaccine is associated with a reduced risk of dementia

68/100 ✓ Peer-reviewed Prevention and risk Nature Communications

Key finding: Vaccines to prevent herpes zoster have been associated with reduced dementia risk. +4 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration

45/100 ✓ Peer-reviewed Biomarkers Ageing research reviews

Key finding: These minimally invasive biomarkers demonstrate exceptional diagnostic accuracy with p-tau217 achieving AUC values greater 0.93 and 91 % positive predictive value in detecting AD pathology, Critically, these biomarkers can identify pathological changes 15-20 years before symptom onset, with plasma p-tau217 levels increasing over 8.5 % annually during preclinical stages. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Evaluation of plasma p-tau217 biomarkers in detecting amyloid pathology and predicting cognitive outcomes: Observations from Japanese Alzheimer's disease neuroimaging initiative cohort

66/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: Plasma p-tau217 levels measured using Lumipulse and Simoa assays were highly correlated (p < 0.001). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial

67/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology

Key finding: A meta-analysis of two multidomain lifestyle intervention trials found greater cognitive benefits in APOE4 carriers compared with non-carriers. +3 more findings

• Clinical Trials
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Beyond Glycemic Control: GLP-1RA–Based Therapies and Emerging Targets Beyond the Metabolic Axis

41/100 ✓ Peer-reviewed Drug development Journal of clinical medicine

Key finding: Considering the overall sci-entific evidence presented, it is important to note that GLPs are no longer just antihyperglycemic drugs but are remarkably versatile, with a future in almost every field of medicine. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Associations between low-dose drinking water lithium exposure and Dementia: A nationwide U.S. ecological study

35/100 ✓ Peer-reviewed Risk factors Environmental pollution (Barking, Essex : 1987)

Key finding: Compared with counties with low lithium concentrations, those with high concentrations had lower dementia prevalence (prevalence ratio [PR] = 0.965, 95% CI: 0.950, 0.981) and incidence (incidence rate ratio [IRR] = 0.958, 95% CI: 0.939, 0.978), exhibiting non-linear dose-response patterns. +1 more finding

Full summary, score breakdown and related studies → Original source

Comprehensive Review on Alzheimer Disease: Causes, Risk Factors, Pathology, Mechanisms

41/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: The article also explores newer monoclonal antibodies—donanemab, gantenerumab, solanezumab, bapineuzumab, crenezumab, and semorinemab—and evaluates nutritional supplements like vitamin E (alpha-tocopherol) and caprylidene. +4 more findings

• Treatments
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Comprehensive Review on Alzheimer Disease: Causes, Risk Factors, Pathology, Mechanisms

29/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: The article also explores newer monoclonal antibodies—donanemab, gantenerumab, solanezumab, bapineuzumab, crenezumab, and semorinemab—and evaluates nutritional supplements like vitamin E (alpha-tocopherol) and caprylidene. +4 more findings

• Treatments
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort

45/100 ✓ Peer-reviewed Genetics Carolina Digital Repository (University of North Carolina at Chapel Hill)

Key finding: Compared with men, women had greater amyloid burden (B = 0.05; 95% CI, 0.02-0.07; P < .001), Braak stages III and IV (B = 0.05; 95% CI, 0.02-0.08; P = .003) and Braak stages V and VI (B = 0.09; 95% CI, 0.06-0.12; P < .001) tau burden, and AD signature thickness (B = 0.04; 95% CI, 0.02-0.05; P < .001). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Causality between noise pollution and Alzheimer disease: A Mendelian randomization analysis

32/100 ✓ Peer-reviewed Genetics Medicine

Key finding: The role of noise pollution as a risk factor for Alzheimer disease (AD) is unclear, with observational studies yielding conflicting results susceptible to confounding and reverse causality. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Biomarcadores para diagnóstico e prognóstico de Alzheimer

31/100 ✓ Peer-reviewed Biomarkers Revista Brasileira Militar de Ciências

Key finding: Trata-se de uma revisão integrativa da literatura com base no modelo PRISMA, com seleção de estudos nas bases de dados Portal de Periódicos da PubMed/Medline, Scielo e Biblioteca Virtual em Saúde, empregando os descritores: Alzheimer, biomarcadores, probióticos, em português e inglês, no período de 2019 a 2024. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source