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Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project
Iván David Lozada-Martínez, Sandra Milena Castelblanco Toro, Hernan Felipe Guillen-Burgos, Juan Carlos Salazar, Juan‐Manuel Anaya. Alzheimer s & Dementia, 2025-12-01
Topic: Risk, prevention and care in population studies
Among 160 centenarians, 63.7% did not meet the PCFP criteria and were classified as having dementia. Frailty, alcohol intake, and depression were linked to dementia, while physical performance, nutritional status, and quality of life were associated with PCFP. Physical activity, education, obesity, hypertension, diabetes, and smoking showed no significant associations. Traditional dementia risk factors were not universally confirmed in centenarians, underscoring the need for prevention strategies tailored to specific settings. HIGHLIGHTS: Dementia risk factors act differently in Colombian centenarians. Frailty and malnutrition strongly linked to dementia in centenarians. Preserved cognitive-functional phenotype identified in 36% of centenarians. Quality of life and physical performance protect against cognitive decline. Classical risk factors (education, hypertension, diabetes) showed no effect.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lozada-Martínez, I. D., Toro, S. M. C., Guillen-Burgos, H. F., Salazar, J. C., & Anaya, J. (2025). Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project. Alzheimer s & Dementia. https://doi.org/10.1002/alz.71034
Vancouver
Lozada-Martínez ID, Toro SMC, Guillen-Burgos HF, Salazar JC, Anaya J. Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project. Alzheimer s & Dementia. 2025. doi:10.1002/alz.71034. PMID: 41400045.
BibTeX
@article{lozadamartinez2025-41400045,
author = {Lozada-Martínez, Iván David and Toro, Sandra Milena Castelblanco and Guillen-Burgos, Hernan Felipe and Salazar, Juan Carlos and Anaya, Juan‐Manuel},
title = {{Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.71034},
pmid = {41400045},
url = {https://doi.org/10.1002/alz.71034}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Among 160 centenarians, 63.7% did not meet the PCFP criteria and were classified as having dementia.
- Frailty, alcohol intake, and depression were linked to dementia, while physical performance, nutritional status, and quality of life were associated with PCFP.
- Physical activity, education, obesity, hypertension, diabetes, and smoking showed no significant associations.
- Traditional dementia risk factors were not universally confirmed in centenarians, underscoring the need for prevention strategies tailored to specific settings.
- HIGHLIGHTS: Dementia risk factors act differently in Colombian centenarians.
Why it matters
Among Colombian centenarians, frailty, alcohol intake and depression were linked to dementia, while physical activity, education, obesity, hypertension, diabetes and smoking showed no significant associations. This suggests traditional dementia risk factors may not apply universally and prevention must be tailored to specific settings.
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Study details
- Effect size63.7%
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Juan‐Manuel Anaya: h-index 86 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidad Nacional de Colombia: institution h-index 323 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41400045) |
| Free to read | 2 / 2 | Free to read |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
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