This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Down syndrome and Alzheimer's

Topic: Amyloid, tau and blood-test diagnosis

In partial correlations adjusted for age, there was a significant positive association between the cardiovascular composite (r = .156, p = .016) and resistance score; higher cardiovascular composite was associated with greater than expected Aβ for age. At the item level, hyperlipidemia was associated with a 1.8 x higher likelihood of greater than expected Aβ for age (OR = 1.83, p = .047). There was not a significant correlation between the cardiovascular composite and the resilience scores. Cardiovascular conditions may alter resistance to DSAD, including an earlier age of Aβ accumulation, and be an important target for delaying or preventing DSAD.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Brothers, C. E., Wisch, J. K., Handen, B. L., Lao, P. J., Ances, B. M., Kennedy, J. T., et al. (2025). Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease. Alzheimer s & Dementia. https://doi.org/10.1002/alz70857_099395

Vancouver

Brothers CE, Wisch JK, Handen BL, Lao PJ, Ances BM, Kennedy JT, et al. Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease. Alzheimer s & Dementia. 2025. doi:10.1002/alz70857_099395. PMID: 41444861.

BibTeX

@article{brothers2025-41444861,
  author  = {Brothers, Courtney E and Wisch, Julie K. and Handen, Benjamin L. and Lao, Patrick J. and Ances, Beau M. and Kennedy, James Tyler and Zammit, Matthew D. and Christian, Bradley T. and others},
  title   = {{Cardiovascular Risk Composite and Time of Amyloid Accumulation and Cognitive Decline in Down Syndrome Alzheimer's Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70857_099395},
  pmid    = {41444861},
  url     = {https://doi.org/10.1002/alz70857_099395}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

In partial correlations adjusted for age, there was a significant positive association between the cardiovascular composite (r = .156, p = .016) and resistance score; higher cardiovascular composite was associated with greater than expected Aβ for age.
At the item level, hyperlipidemia was associated with a 1.8 x higher likelihood of greater than expected Aβ for age (OR = 1.83, p = .047).
There was not a significant correlation between the cardiovascular composite and the resilience scores.
Cardiovascular conditions may alter resistance to DSAD, including an earlier age of Aβ accumulation, and be an important target for delaying or preventing DSAD.

Why it matters

In people with Down syndrome and Alzheimer's disease, a higher cardiovascular risk score was linked to greater amyloid accumulation for age, and hyperlipidemia was linked to a 1.8 times higher likelihood of this. Managing cardiovascular conditions may help delay or prevent Alzheimer's in this group, though the study does not prove cause and effect.

Study details

Participants262
Effect sizeOR = 1.83
Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	262 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Charles K. Stone: h-index 27 (OpenAlex, whole career)
Institution's track record	2 / 3	Washington University in St. Louis: institution h-index 1,962 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 6 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41444861)
Free to read	2 / 2	Free to read
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Related studies in Down syndrome and Alzheimer's

Also tagged “down”

527 studies in the library carry the topic tag “down”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 527 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Down syndrome and Alzheimer's

See all studies in Down syndrome and Alzheimer's →