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Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study
Merete Ellingjord‐Dale, Bjørn Heine Strand, Vegard Skirbekk, Bernt Bratsberg, Teferi Mekonnen, Ekaterina Zotcheva, Geir Selbæk, Yaakov Stern et al.. The Lancet Healthy Longevity, 2025-12-01
Topic: Risk, prevention and care in population studies
Between Sept 1, 2017, and Feb 28, 2019, 19 403 individuals were invited to participate and 9745 participants (1525 with dementia, 8220 without dementia) were included. 4445 (45·6%) of 9745 participants were male and 5300 (54·4%) were female. The total PAF for the 14 Lancet risk factors was 50·9% (95% CI 37·7-61·4). Including family-related and work-related risk factors increased the PAF to 54·9% (42·3-64·7; p<0·0001). When these factors were added for women, the total PAF increased from 48·0% (95% CI 29·4-61·7) to 52·2% (34·2-65·3; p=0·0090), whereas no significant change was observed in men (56·2% [95% CI 35·5-70·2] to 56·7 [95% CI 36·1-70·6]; p=0·71). Addressing all 14 Lancet risk factors could prevent over half of all dementia cases. Adding factors related to marital and occupational status offers additional preventive potential, particularly among women. FUNDING: The National Institutes of Health and NRC-ATWORK.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ellingjord‐Dale, M., Strand, B. H., Skirbekk, V., Bratsberg, B., Mekonnen, T., Zotcheva, E., et al. (2025). Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study. The Lancet Healthy Longevity. https://doi.org/10.1016/j.lanhl.2025.100802
Vancouver
Ellingjord‐Dale M, Strand BH, Skirbekk V, Bratsberg B, Mekonnen T, Zotcheva E, et al. Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study. The Lancet Healthy Longevity. 2025. doi:10.1016/j.lanhl.2025.100802. PMID: 41475703.
BibTeX
@article{ellingjorddale2025-41475703,
author = {Ellingjord‐Dale, Merete and Strand, Bjørn Heine and Skirbekk, Vegard and Bratsberg, Bernt and Mekonnen, Teferi and Zotcheva, Ekaterina and Selbæk, Geir and Stern, Yaakov and others},
title = {{Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study}},
journal = {The Lancet Healthy Longevity},
year = {2025},
doi = {10.1016/j.lanhl.2025.100802},
pmid = {41475703},
url = {https://doi.org/10.1016/j.lanhl.2025.100802}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Between Sept 1, 2017, and Feb 28, 2019, 19 403 individuals were invited to participate and 9745 participants (1525 with dementia, 8220 without dementia) were included. 4445 (45·6%) of 9745 participants were male and 5300 (54·4%) were female.
- The total PAF for the 14 Lancet risk factors was 50·9% (95% CI 37·7-61·4).
- Including family-related and work-related risk factors increased the PAF to 54·9% (42·3-64·7; p<0·0001).
- When these factors were added for women, the total PAF increased from 48·0% (95% CI 29·4-61·7) to 52·2% (34·2-65·3; p=0·0090), whereas no significant change was observed in men (56·2% [95% CI 35·5-70·2] to 56·7 [95% CI 36·1-70·6]; p=0·71).
- Addressing all 14 Lancet risk factors could prevent over half of all dementia cases.
Why it matters
This Norwegian cohort estimated that addressing all 14 Lancet risk factors could prevent over half of dementia cases, with additional preventive potential from marital and occupational factors, particularly in women. These are population-level estimates of preventable proportion, not evidence that any specific intervention works.
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Study details
- Study designcohort study
- Participants403
- Evidence strengthModerate
How this study scored 55/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet Healthy Longevity) |
| Journal's citation record | 1 / 4 | The Lancet Healthy Longevity: journal h-index 78 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 403 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Bo Engdahl: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Columbia University: institution h-index 1,824 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41475703) |
| Free to read | 2 / 2 | Free to read |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.lanhl.2025.100802
- PubMed: 41475703
- Original source →
- Free full text: The Lancet Healthy Longevity →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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