DIAGNOSTIC APPROCH ON ALZHEIMER'S DISEASE

Topic: Amyloid, tau and blood-test diagnosis

Alzheimer’s disease is the most common type of dementia, characterized by a progressive decline in cognitive function, particularly memory and impacting daily life. It is a neurodegenerative disorder involving the abnormal build-up of proteins in the brain forming plaques. These protein aggregates and disrupt normal brain cell function leading to neuron damage. It is an undertreated and under-recognized disease that is becoming a major public health problem. The last decade has witnessed a steadily increasing effort directed at discovering the aetiology of the disease and developing pharmacological treatment. This disease starts after the age of 55-60 but in down syndrome patients it starts earlier at the age of 40-50. Some of the chemicals used as inducing agents are scopolamine, colchicine, Okadaic acid, Trimethyl tin and some of the metal ions are used in animal models. Alzheimer’s disease is similar to that of coronary heart disease or ischemic. Background: - It was first described in 1906 by Dr. Alois Alzheimer, after studying a patient named Auguste D, who exhibited symptoms like memory loss and language problem.

Key findings

• This disease starts after the age of 55-60 but in down syndrome patients it starts earlier at the age of 40-50.
• Some of the chemicals used as inducing agents are scopolamine, colchicine, Okadaic acid, Trimethyl tin and some of the metal ions are used in animal models.
• Alzheimer’s disease is similar to that of coronary heart disease or ischemic.
• Background: - It was first described in 1906 by Dr.
• Alois Alzheimer, after studying a patient named Auguste D, who exhibited symptoms like memory loss and language problem.

Why it matters

This is a general review of Alzheimer's disease diagnosis and background, noting that the disease starts earlier in people with Down syndrome. It reports no new findings on treating, curing or preventing Alzheimer's disease.

Study details

• Evidence strengthLow

Read the original

• DOI: 10.5281/zenodo.17735839
• Original source →
• Free full text: Zenodo (CERN European Organization for Nuclear Research) →

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

@article{bhute2025-9a8a0004,
  author  = {Bhute, Miss. Akanksha Wasudeorao and Gajbhiye, Miss. Lochani S. and Kothari, Miss. Khushi S. and Lokhande, Prof. Vishnudas and Bijwar, Dr. Rahul},
  title   = {{DIAGNOSTIC APPROCH ON ALZHEIMER'S DISEASE}},
  journal = {World Journal of Pharmacy and Pharmaceutical Sciences},
  year    = {2025},
  doi     = {10.5281/zenodo.17735839},
  url     = {https://doi.org/10.5281/zenodo.17735839}
}

Related studies in Down syndrome and Alzheimer's

• Diagnostic performance of plasma Aβ 1-42 , Aβ 1-40 and pTau 181 in the LUMIPULSE automated platform for the detection of Alzheimer disease medRxiv · 2023-04-26 · usefulness score 16/100
• Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction bioRxiv · 2026-10-30 · usefulness score 16/100
• Memory and Plasma pTau217 Refine Prognosis in Down Syndrome Annals of neurology · 2026-10-02 · usefulness score 47/100
• Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026-10-01 · usefulness score 53/100
• Sleep Health in Adults with Intellectual Disability: Recent Advances and Persistent Evidence Gaps Current Treatment Options in Neurology · 2026-09-25 · usefulness score 42/100
• Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan Journal of Clinical Medicine · 2026-09-25 · usefulness score 32/100

Also in Down syndrome and Alzheimer's

12 studies in the library are filed under Down syndrome and Alzheimer's with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Down syndrome and Alzheimer's hub.

• Disease-specific patterns of locus coeruleus cell loss Annals of neurology · 1992-11-01 · usefulness score 40/100 · Down syndrome and Alzheimer's
• Disturbed homocysteine metabolism is associated with cancer Experimental & molecular medicine · 2019-02-21 · usefulness score 41/100 · Down syndrome and Alzheimer's
• Present and future of Alzheimer therapy Journal of neural transmission. Supplementum · 2000-01-01 · usefulness score 38/100 · Down syndrome and Alzheimer's

Similar studies

• Down syndrome and Alzheimer disease 1992 · Down syndrome and Alzheimer's
• Development of Alzheimer disease in Down syndrome individuals 1983 · Down syndrome and Alzheimer's
• [Alzheimer-type dementia and Down syndrome] 1995 · Down syndrome and Alzheimer's
• Alzheimer's disease 2012 · Getting a diagnosis
• A prospective study of Alzheimer disease in Down syndrome 1989 · How common it is
• The Clinical Diagnosis of Alzheimer's Disease 1987 · Getting a diagnosis

More on Down syndrome and Alzheimer's

• Newest in this subject Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder Communications Medicine · 2026-09-21 · Peer-reviewed · usefulness score 47/100
• Newest in this subject Down syndrome postmortem brains exhibit reduction in [ 18 F]nifene binding to α4β2* nicotinic acetylcholinergic receptors bioRxiv · 2026-09-15 · Preprint — not yet peer-reviewed · usefulness score 16/100

See all studies in Down syndrome and Alzheimer's →