Newest studies

Early detection of Alzheimer's disease: From multiplex assays and imaging to point of care devices and AI-based functional monitoring

43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD

Key finding: The advent of disease-modifying treatments and risk-reduction strategies in the clinic have increased the demand for biomarkers for early disease detection, prediction of clinical course of disease, individual risk prediction and monitoring of treatment effects. +1 more finding

• Diagnosis
• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Mitochondrial blood-based biomarker is related to cardiorespiratory fitness and aging in a sex-dependent manner

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)

Key finding: As expected, males had higher lean mass and VO2peak than females (p = 0.01), but groups did not differ in body mass index (p = 0.51). +4 more findings

• Biomarkers
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Simulation of Alzheimer's diagnostic flows with blood biomarker test options in Japan

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)

Key finding: The maximum mean wait time under the current workflow was projected at 6.4 months, decreasing with BBM integration. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Neurofilament Biomarkers in Neurology: From Neuroinflammation to Neurodegeneration, Bridging Established and Novel Analytical Advances with Clinical Practice

45/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: In multiple sclerosis (MS), serum NfL correlates with disease activity, treatment response, and long-term disability, and may complement MRI in monitoring subclinical progression. +4 more findings

• Biomarkers
• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Compositional Control of Aging Kinetics in TDP-43 Condensates

39/100 ✓ Peer-reviewed Brain tissue and pathology PRX Life

Key finding: Together, our findings underscore the major role of client biomolecules in controlling the propensity of multicomponent condensates to form harmful solidlike states.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Glymphatic activity is linked to the synaptic vesicle cycle pathway in frontotemporal dementia: A metabolomics study

40/100 ✓ Peer-reviewed Lewy body dementia Neurobiology of Disease

Key finding: We aimed to explore potential underlying metabolic pathways associated with glymphatic dysfunction in FTD. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia

43/100 ✓ Peer-reviewed Lewy body dementia Brain

Key finding: We present the pharmacological properties of EKZ-438, which demonstrate high selectivity for HDAC6 (>8500-fold selectivity for HDAC6 versus all other HDAC6 paralogues), low nanomolar potency (12 nM) for HDAC6, and importantly, CNS-penetrance (unbound brain-to-plasma partition coefficient [Kp,uu,brain] ≥ 0.55) and high oral bioavailability (fraction of dose absorbed [F%] = 70). +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Development and validation of a predictive nomogram for mild cognitive impairment in middle-aged and elderly populations: A multi-module analysis integrating air quality and sociodemographic factors

39/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: The validated nomogram enables individualized MCI risk stratification, supporting targeted community prevention strategies. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Regional tau PET patterns predict prospective domain-specific cognitive decline in early symptomatic Alzheimer's disease

54/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy

Key finding: Differential FTP-PET signal patterns showed significant negative associations with domain-specific annual rates of decline. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

A Biomarker-Based Classification of Corticobasal Syndrome

61/100 ✓ Peer-reviewed Brain scans and imaging Movement disorders : official journal of the Movement Disorder Society

Key finding: Tau positivity was found in 90% of CBS cases, Aβ in 28%, and αSyn in 24%. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Living well with dementia: a qualitative interview study on family caregivers’ call for more person- and family-centered dementia support

38/100 ✓ Peer-reviewed Caregiving BMC Geriatrics

Key finding: Three themes were identified: (1) Struggling with conflicting emotions and social challenges - caregivers reported experiencing stress, physical exhaustion, and emotional strain due to constant availability and the challenges of managing behavioral changes, further intensified by isolation and shrinking social networks. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Latino Caregiver Experiences With Dementia Care and Healthcare Navigation

39/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: We identified two main themes (each with subthemes) that influence Latino dementia caregiver experiences with healthcare: (1) caregiving and understanding of dementia shaped by individual, family, and social factors (subthemes: Caregiver's own understanding of dementia; Lack of support and understanding from family; Latino cultural perspectives on dementia); and (2) navigating formal services amid gaps in cultural alignment and support (subthemes: Trial and error: education and resource gaps; Cultural tension with healthcare). +3 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

Varicella-zoster virus reactivation and the risk of dementia

63/100 ✓ Peer-reviewed Prevention and risk Nature Medicine

Key finding: VZV reactivation is associated with a wide range of symptoms, including herpes zoster (HZ; also known as shingles), and has been implicated in the development of dementia, although to an unknown extent. +3 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Krankheitsmodifizierende Therapie mit Lecanemab bei früher Alzheimer-Demenz

35/100 ✓ Peer-reviewed Treatments Fortschritte der Neurologie · Psychiatrie

Key finding: Erstens sollen homozygote ApoE4 Träger und zweitens Patienten, die eine orale Antikoagulantien erhalten, Lecanemab nicht erhalten. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Alzheimer Disease, Vascular Disease, and Blood-Brain Barrier Permeability Biomarkers in Middle-Aged Adults

54/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: The findings suggest that permeability of the blood-brain barrier is linked to AD pathophysiology, contributes to cerebrovascular lesions observed on MRI, and is associated with neuroinflammation in middle age. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Benzoxazole Derivatives as Dual p38α Mitogen‐Activated Protein Kinase and Acetylcholinesterase Inhibitors: Design, Synthesis, and Evaluation for Alzheimer's Disease and Cancer Therapy

40/100 ✓ Peer-reviewed Disease mechanisms ChemMedChem

Key finding: Additionally, dysregulation of p38α MAPK is associated with tumorigenesis, making it a promising target for both neurodegenerative and proliferative diseases. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Meta meta-analysis of cardiovascular risk factors in Alzheimer's disease

71/100 ✓ Peer-reviewed Risk factors eNeurologicalSci

Key finding: The total effect of cholesterol on risk of AD was significant and heterogeneous. +4 more findings

• Risk Factors

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Urban–rural disparities in dementia-related mortality among older adults in the U.S. from 1999 to 2020

29/100 ✓ Peer-reviewed Disparities Archives of Gerontology and Geriatrics Plus

Key finding: In rural areas, 61.8 % of dementia deaths occurred in nursing homes compared to 53.9 % in urban areas. +2 more findings

• Health Equity
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Precision prevention in exercise: Integrating OMICS biomarkers and artificial intelligence for injury risk assessment

38/100 ✓ Peer-reviewed Prevention and risk Advanced Exercise and Health Science

Key finding: Exercise injuries present a significant challenge in medicine and public health, impacting exercise performance, career longevity, and overall quality of life. +2 more findings

• Digital Tools
• Prevention
• Biomarkers

Full summary, score breakdown and related studies → Original source

Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria

43/100 ✓ Peer-reviewed Drug development Frontiers in neuroendocrinology

Key finding: Primary mitochondrial disorders (e.g., Leigh syndrome) are uniformly associated with profound neurodegeneration. +1 more finding

• Treatments
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid-related Imaging Abnormalities (ARIA) in the Context of Alzheimer's Disease and Amyloid-targeting Therapies: An Introduction for Advanced Practice Providers

45/100 ✓ Peer-reviewed Treatments Drugs & aging

Key finding: Treating clinicians should be equipped with a comprehensive understanding of ARIA. +4 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Global burden, quality of care, and cross-country inequalities in Alzheimer’s disease and other dementias from 1990 to 2021

43/100 ✓ Peer-reviewed Disparities Journal of Global Health

Key finding: The global age-standardised DALY rates of ADRDs per 100 000 population slightly increased from 1331.59 (95% confidence interval (CI) = 881.57, 1781.61) in 1990 to 1347.24 (95% CI = 906.36, 1788.12) in 2021, with an AAPC of 0.04% (95% CI = 0.02, 0.05). +4 more findings

• Health Equity

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Association between different types of lung cancer and neurodegenerative diseases: A two-sample Mendelian randomization study

35/100 ✓ Peer-reviewed Genetics Medicine

Key finding: Previous observational studies demonstrated that lung cancer and both Alzheimer disease (AD) and Parkinson disease (PD) may be related. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Exploring causal relationships between epigenetic age acceleration and Alzheimer’s disease: a bidirectional Mendelian randomization study

39/100 ✓ Peer-reviewed Genetics Clinical Epigenetics

Key finding: Employing the random-effects IVW approach, we found that, as indicated by GrimAge, EAA was associated with an increased risk of AD (Odds Ratio [OR] = 1.025, 95% Confidence Interval [CI]: 1.006-1.044, p = 0.009). +4 more findings

Full summary, score breakdown and related studies → Original source

Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive Impairment

49/100 ✓ Peer-reviewed Genetics Neurology

Key finding: In the HELIAD sample, among 618 cognitively healthy participants (mean age 73.37 years, 58.4% female), followed for 2.92 ± 0.80 years, 73 developed AD/aMCI. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source