Home › Research › Caregiving
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O, Szoeke C, Macaulay SL et al.. The Lancet. Neurology, 2013-03-08
Topic: Amyloid, tau and blood-test diagnosis
At baseline, significantly higher Aβ burdens were noted in patients with AD (2·27, SD 0·43) and those with MCI (1·94, 0·64) than in healthy controls (1·38, 0·39).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Villemagne, V. L., Burnham, S., Bourgeat, P., Brown, B., Ellis, K. A., Salvado, O., et al. (2013). Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. The Lancet. Neurology. https://doi.org/10.1016/s1474-4422(13)70044-9
Vancouver
Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O, et al. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. The Lancet. Neurology. 2013. doi:10.1016/s1474-4422(13)70044-9. PMID: 23477989.
BibTeX
@article{villemagne2013-23477989,
author = {Villemagne, V. L. and Burnham, S. and Bourgeat, P. and Brown, B. and Ellis, K. A. and Salvado, O. and Szoeke, C. and Macaulay, S. L. and others},
title = {{Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study}},
journal = {The Lancet. Neurology},
year = {2013},
doi = {10.1016/s1474-4422(13)70044-9},
pmid = {23477989},
url = {https://doi.org/10.1016/s1474-4422(13)70044-9}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- At baseline, significantly higher Aβ burdens were noted in patients with AD (2·27, SD 0·43) and those with MCI (1·94, 0·64) than in healthy controls (1·38, 0·39).
Why it matters
At the start of this 2013 cohort study, people with Alzheimer's had the most amyloid (Aβ) in the brain on average, people with mild cognitive impairment had less, and healthy controls had the least (2·27, 1·94 and 1·38). The AD and MCI levels were significantly higher than the controls'. This shows amyloid levels are linked to disease stage, not that amyloid causes it. The record reports no results on later brain shrinkage or memory decline, and it tests no treatment.
New to this subject? Start with our plain-English guide: Caregiving →
Study details
- Study designcohort study
- Participants200
- Evidence strengthModerate
How this study scored 74/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet. Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 200 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 2,270 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 151.3 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 6 / 6 | Cited 99.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 172 other studies in this library |
| Still being cited | 4 / 4 | Cited 523 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Colin Louis Masters: h-index 175 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Melbourne: institution h-index 1,342 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23477989) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 74 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 24.
Later studies that cite this one
172 studies in the alzhub library list this one in their references. Showing the 8 highest-scoring.
Related studies in Caregiving
Also tagged “precursor”
1,337 studies in the library carry the topic tag “precursor”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,337 tagged studies.