Newest studies

Alzheimer's disease and sleep disorders: A bidirectional relationship

43/100 ✓ Peer-reviewed Risk factors Neuroscience

Key finding: Emerging evidence has revealed that sleep disorders such as circadian disturbances and disruption of neuronal rhythm activity are considered as both candidate risks and consequence of AD, suggesting a bidirectional relationship between sleep and AD.

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

The MIND diet, brain transcriptomic alterations, and dementia

59/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A brain transcriptomic profile for healthy diets revealed novel genes potentially associated with cognitive health. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

66/100 ✓ Peer-reviewed Prevention and risk The Lancet

Key finding: 14 modifiable risk factors identified: less education, hearing loss, high LDL cholesterol, depression, traumatic brain injury, physical inactivity, diabetes, smoking, hypertension, obesity, excessive alcohol, untreated vision loss, social isolation, and air pollution +2 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer's disease: a review on the current trends of the effective diagnosis and therapeutics

45/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

Key finding: Therefore, accurate and prompt diagnosis of Alzheimer's disease is essential in order to facilitate the development of disease-modifying and secondary preventive therapies prior to the onset of symptoms. +4 more findings

• Treatments
• Clinical Trials
• Diagnosis

Full summary, score breakdown and related studies → Original source

The Mississippi Healthy Aging Data Report: Tools to Advance Health Equity

38/100 ✓ Peer-reviewed Risk factors Journal of Public Health in the Deep South

Key finding: The Mississippi Healthy Aging Data Report (see healthyagingdatareports.org) has helped policymakers, service providers, and advocates better understand the status of healthy aging in Mississippi. +4 more findings

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Refractory Status Epilepticus in a Patient With Aducanumab-Induced Amyloid-Related Imaging Abnormalities

56/100 ✓ Peer-reviewed Drug development Neurology

Key finding: The patient was participating in an extended open-label trial of aducanumab when she was admitted to hospital for focal seizures and ARIA in 2 noncontiguous regions of the left frontal and occipital lobes. +3 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Amyloid age and tau PET timeline to symptomatic Alzheimer’s disease in Down syndrome

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's medRxiv

Key finding: Adults with Down syndrome (DS) are at risk for Alzheimer’s disease (AD). +3 more findings

• Down Syndrome
• Brain Scans

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Reduction in neurons immunoreactive for calcium-binding proteins in the anteroventral thalamic nuclei of individuals with Down syndrome

33/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience

Key finding: While there was a significant increase in neuronal density in the Down syndrome group, the values showed more variation consistent with a heterogeneous population. +2 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Human apolipoprotein E glycosylation and sialylation: from structure to function

43/100 ✓ Peer-reviewed Genetics Frontiers in molecular neuroscience

Key finding: Despite three decades' worth of effort and over 10,000 papers published, the greatest mystery in the ApoE field remains: human ApoE isoforms differ by only one or two amino acid residues; what is responsible for their significantly distinct roles in the etiology of sAD, with ApoE4 conferring the greatest genetic risk for sAD whereas ApoE2 providing exceptional neuroprotection against sAD. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Geographic Variation of Prevalence of Alzheimer’s Disease and Related Dementias in Central Appalachia

41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: Across the 591 counties in the Central Appalachian region, the average prevalence of ADRD from 2015- 2018 was 11.8%. +4 more findings

Full summary, score breakdown and related studies → Original source

Impact of Air Pollution on Neurological and Psychiatric Health

43/100 ✓ Peer-reviewed Risk factors Archives of medical research

Key finding: Air pollution is a critical global issue with extensive implications beyond respiratory health, significantly affecting neurological and psychiatric disorders.

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Deep learning-based amyloid PET harmonization to predict cognitive decline in non-demented elderly

59/100 ✓ Peer-reviewed Brain scans and imaging Radiology advances

Key finding: DL-ADprob was independently prognostic in both ADNI-MCI (P < .001) and HABS-CU (P = .048) sets. +4 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Genetic disease amongst the Plain community

43/100 ✓ Peer-reviewed Genetics Current opinion in pediatrics

Key finding: For decades, the study of genetically isolated populations has improved our understanding and management of genetic diseases that affect all populations. +4 more findings

• Genetics
• Health Equity

Full summary, score breakdown and related studies → Original source

Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases

60/100 ✓ Peer-reviewed Brain tissue and pathology Nature reviews. Molecular cell biology

Key finding: Their postmitotic nature and extremely polarized morphologies make neurons particularly vulnerable to disruptions caused by autophagy-lysosomal defects, especially as the brain ages. +3 more findings

Full summary, score breakdown and related studies → Original source

Medicare Advantage Prior Authorization Requirements for Otolaryngologic Procedures in 2021

40/100 ✓ Peer-reviewed Health systems and care delivery Otolaryngology–Head and Neck Surgery

Key finding: Little is known about the extent of prior authorization requirements in otolaryngology. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Associations of social determinants of health with life expectancy and future health risks among individuals with type 2 diabetes: two nationwide cohort studies in the UK and USA

63/100 ✓ Peer-reviewed Long-term cohort studies The lancet. Healthy longevity

Key finding: Social determinants of health (SDHs) are the primary drivers of preventable health inequities, and the associations between SDHs and health outcomes among individuals with type 2 diabetes remain unclear. +3 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer's Disease

43/100 ✓ Peer-reviewed Disease mechanisms Nutrients

Key finding: The gastrointestinal (GI) tract, home to the largest microbial population in the human body, plays a crucial role in overall health through various mechanisms. +3 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Repurposing Anidulafungin for Alzheimer's Disease via Fragment-Based Drug Discovery

43/100 ✓ Peer-reviewed Drug development ACS chemical neuroscience

Key finding: In this study, we used an in silico FBDD approach to identify 17 fragment clusters that are significantly enriched among Aβ aggregation inhibitors. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

New IPECAD Open-Source Model Framework for the Health Technology Assessment of Early Alzheimer's Disease Treatment: Development and Use Cases

43/100 ✓ Peer-reviewed Health systems and care delivery Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Key finding: In the IPECAD model incremental life-years, quality-adjusted life-years (QALY) gains and cost savings were 21% to 31% smaller compared with the ICER model and 36% to 56% smaller compared with the AD-ACE model. +2 more findings

• Treatments
• Digital Tools
• Policy

Full summary, score breakdown and related studies → Original source

Factors associated with the place of death of persons with advanced dementia: A systematic review of international literature with meta-analysis

54/100 ✓ Peer-reviewed Health systems and care delivery Palliative medicine

Key finding: Papers reporting quantitative data on factors associated with place of death in advanced dementia were included and appraised using QualSyst.

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Traumatic Brain Injury, Seizures, and Cognitive Impairment Among Older Adults

66/100 ✓ Peer-reviewed Disparities JAMA network open

Key finding: Among the cohort of 7180 older adults (median age, 74 years [range, 65-102 years]; 4729 women [65.9%]), 1036 were African American or Black (14.4%), 21 were American Indian or Alaska Native (0.3%), 143 were Asian (2.0%), 332 were Hispanic (4.6%), and 5648 were non-Hispanic White (78.7%); the median educational level was 16.0 years (range, 1.0-29.0 years). +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Inadequate insurance coverage for overweight/obesity management

46/100 ✓ Peer-reviewed Disparities The American journal of managed care

Key finding: Obesity is a significant health crisis affecting more than 123 million adults and children/adolescents in the US. +4 more findings

• Policy
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cholesterol imbalance and neurotransmission defects in neurodegeneration

43/100 ✓ Peer-reviewed Disease mechanisms Experimental & molecular medicine

Key finding: The maintenance of cholesterol homeostasis in the neuronal plasma membrane is essential for normal brain function, and imbalances in cholesterol distribution are associated with various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Navigating Prevention: A Systematic Review of Strategies for Alzheimer's Disease in High-Risk and Affected Individuals

50/100 ✓ Peer-reviewed Prevention and risk Cureus

Key finding: The current treatment focuses on addressing symptoms, with ongoing trials aiming to decrease the production and overall impact of brain pathology.

• Prevention
• Brain Biology

Full summary, score breakdown and related studies → Original source

Multimodal Retinal Imaging Classification for Parkinson's Disease Using a Convolutional Neural Network

43/100 ✓ Peer-reviewed Brain scans and imaging Translational vision science & technology

Key finding: In total, 371 eyes of 249 control subjects and 75 eyes of 52 PD subjects were used for training, validation, and testing. +4 more findings

• Brain Scans
• Other Dementias
• Digital Tools

Full summary, score breakdown and related studies → Original source