Topic: Amyloid, tau and blood-test diagnosis
Objective Data from the Einstein Aging Study (EAS) were used to prospectively evaluate the free recall score from the free and cued selective reminding test (FCSRT-FR) and logical memory I immediate recall (LM-IR) subtest of the Wechsler memory scale-revised for prediction of incident Alzheimer disease (AD) dementia among individuals from a community-based cohort with memory complaints. Methods Analyses included 854 participants, age ≥70 years, who initially had no dementia, and had memory complaints. Clinic evaluations were completed annually and AD dementia was diagnosed using standard criteria (n = 86 cases; average follow-up 4.1 years). Time-dependent receiver operating characteristic analysis was used to evaluate the prognostic ability of FCSRT-FR and LM-IR for incident AD over various durations of follow-up. Results For identifying those with memory complaints who will develop incident AD dementia over 2-4 years, the FCSRT-FR had better operating characteristics than LM-IR. APOE ε4 status, age, and education did not affect cut points; however, positive predictive values were higher among APOE ε4-positive individuals. Conclusions For follow-up intervals of 2-4 years, the FCSRT-FR is more predictive than the LM-IR for identifying individuals with memory complaints who will develop incident AD. APOE ε4 status improves positive predictive value, but does not affect the choice of optimal cuts.
Key findings
- Results For identifying those with memory complaints who will develop incident AD dementia over 2-4 years, the FCSRT-FR had better operating characteristics than LM-IR.
Why it matters
In 854 people aged 70 or older who had memory complaints but no dementia, followed for about 4 years in the Einstein Aging Study (86 developed Alzheimer dementia), the free-recall score from the Free and Cued Selective Reminding Test predicted who would develop Alzheimer dementia over 2–4 years better than the Wechsler Logical Memory immediate-recall test. The best cut-off scores were the same regardless of APOE ε4 status, age or education. Among APOE ε4 carriers, a low score was more likely to be correct in flagging future dementia (higher positive predictive value). This is a group-level prediction study, not a diagnostic test for individuals.
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Study details
- Participants86
- Evidence strengthModerate
How this study scored 53/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 86 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 112 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.5 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 3 / 6 | Cited 7.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 15 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Richard B. Lipton: h-index 183 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Albert Einstein College of Medicine: institution h-index 973 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23468542) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
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Read the original
- DOI: 10.1212/wnl.0b013e31828ab2c9
- PubMed: 23468542
- Original source →
- Free full text: PubMed Central →
Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Derby, C. A., Burns, L. C., Wang, C., Katz, M. J., Zimmerman, M. E., L'italien, G., et al. (2013). Screening for predementia AD: time-dependent operating characteristics of episodic memory tests. Neurology. https://doi.org/10.1212/wnl.0b013e31828ab2c9
Vancouver
Derby CA, Burns LC, Wang C, Katz MJ, Zimmerman ME, L'italien G, et al. Screening for predementia AD: time-dependent operating characteristics of episodic memory tests. Neurology. 2013. doi:10.1212/wnl.0b013e31828ab2c9. PMID: 23468542.
BibTeX
@article{derby2013-23468542,
author = {Derby, C. A. and Burns, L. C. and Wang, C. and Katz, M. J. and Zimmerman, M. E. and L'italien, G. and Guo, Z. and Berman, R. M. and others},
title = {{Screening for predementia AD: time-dependent operating characteristics of episodic memory tests}},
journal = {Neurology},
year = {2013},
doi = {10.1212/wnl.0b013e31828ab2c9},
pmid = {23468542},
url = {https://doi.org/10.1212/wnl.0b013e31828ab2c9}
}
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