alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 18,826–18,850 of 27,380 studies, newest first · page 754 of 1096.

March 2013 21

  1. 2013-03-05

    Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease

    ✓ Peer-reviewed Treatments NeuroImage. Clinical

    Key finding: Almost ten years of research have led to a few consensual and relatively consistent findings: some cognitively normal elderly have Aβ deposition in their brain, the prevalence of amyloid-positive cases increases in at-risk populations, the prognosis for these individuals is worse than for those with no Aβ deposition, and significant increase in Aβ deposition over time is detectable in cognitively normal elderly. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2013-03-05

    End-of-life decisions: a cross-national study of treatment preference discussions and surrogate decision-maker appointments

    ✓ Peer-reviewed End-of-life care PloS one

    Key finding: The study revealed a higher prevalence of treatment preference discussions and surrogate appointments in the two northern compared to the two southern European countries. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2013-03-05

    PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease

    ✓ Peer-reviewed Risk factors Experimental gerontology

    Key finding: The integrated coordination of neuronal responses through the PI3-K/Akt pathway has significant functional impact on key events that go awry in Alzheimer's disease (AD), including: synaptic plasticity, neuronal polarity, neurotransmission, proteostasis, use-dependent translation, metabolic control and stress responses including DNA repair.

    Full summary, score breakdown and related studies → Original source

  4. 2013-03-05

    Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

    ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology

    Key finding: Originally termed 'dementia pugilistica' and linked to a career in boxing, descriptions of the neuropathological features of CTE include brain atrophy, cavum septum pellucidum, and amyloid-β, tau and TDP-43 pathologies, many of which might contribute to clinical syndromes of cognitive impairment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2013-03-01

    Alpha‐synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

    ✓ Peer-reviewed Brain tissue and pathology Movement Disorders

    Key finding: The variant was not observed in public databases or identified in unrelated subjects. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2013-03-01

    Efficient in vivo delivery of antisense oligonucleotide to choroid plexus

    ✓ Peer-reviewed Drug development Journal of medical and dental sciences

    Key finding: The ASO was not delivered to neurons or glia in the central nervous system, but was successfully delivered into the CP, and resulted in a significant reduction of endogenous target gene expression in epithelial cells within the CP. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2013-03-01

    Retinal nerve fiber layer thickness in patients with Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    Key finding: The aim of this study was to investigate retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) without visual impairment using spectral domain optical coherence tomography (SD-OCT) and to compare the results with healthy controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2013-03-01

    Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease

    ✓ Peer-reviewed Genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Genome-wide association studies have indicated that ABCA7 single nucleotide polymorphisms confer increased risk for late-onset AD; however, the role that ABCA7 plays in the brain in the AD context is unknown. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2013-03-01

    Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: Cognitive deficits and depression appear to be more common in aging former NFL players compared with healthy controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2013-03-01

    Cognitive impairment after lacunar stroke: systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes

    ✓ Peer-reviewed Vascular contributions Journal of neurology, neurosurgery, and psychiatry

    Key finding: We identified 24 relevant studies of 7575 patients, including 2860 with lacunar stroke; 24% had MCI or dementia post stroke. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2013-03-01

    Cognitive impairment associated with atrial fibrillation: a meta-analysis

    ✓ Peer-reviewed Vascular contributions Annals of internal medicine

    Key finding: Evidence suggests that AF is associated with a higher risk for cognitive impairment and dementia, with or without a history of clinical stroke. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2013-03-01

    Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-amyloid in cognitively normal older individuals

    ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: β-Amyloid (Aβ) plaque deposition and neurodegeneration within temporoparietal and hippocampal regions may indicate increased risk of Alzheimer's disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2013-03-01

    STEPS: Similarity and Truth Estimation for Propagated Segmentations and its application to hippocampal segmentation and brain parcelation

    ✓ Peer-reviewed Hippocampus size on brain scans Medical image analysis

    Key finding: We assessed the method on hippocampal segmentation using a leave-one-out cross validation with optimised model parameters; STEPS achieved a mean Dice score of 0.925 when compared with manual segmentation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2013-03-01

    The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans

    ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology

    Key finding: Recent theories have suggested that chronic pain could be partly maintained by maladaptive physiological responses of the organism facing a recurrent stressor. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2013-03-01

    Motor cortex and gait in mild cognitive impairment: a magnetic resonance spectroscopy and volumetric imaging study

    ✓ Peer-reviewed Clinical safety Brain : a journal of neurology

    Key finding: Our purpose was to determine whether the neurochemistry of the primary motor cortex measured with proton magnetic resonance spectroscopy, and its volume, were associated with gait performance while single and dual-tasking in mild cognitive impairment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2013-03-01

    A review of multidomain interventions to support healthy cognitive ageing

    ✓ Peer-reviewed Prevention trials The journal of nutrition, health & aging

    Key finding: Some evidence suggests that strategies which target multiple factors simultaneously may prove more effective than those focusing on a single mechanism or domain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2013-03-01

    Late-life depression, mild cognitive impairment, and dementia

    ✓ Peer-reviewed Mild cognitive impairment JAMA neurology

    Key finding: The association of depression with prevalent MCI and with progression from MCI to dementia, but not with incident MCI, suggests that depression accompanies cognitive impairment but does not precede it. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2013-03-01

    Controversies and priorities in amyotrophic lateral sclerosis

    ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology

    Key finding: By contrast, the 90% of apparently sporadic cases and incomplete penetrance of several genes linked to familial cases suggest that at least some forms of ALS arise from the interplay of multiple genes, poorly understood developmental, environmental, and age-related factors, as well as stochastic events.

    Full summary, score breakdown and related studies → Original source

  19. 2013-03-01

    Affective disorders and risk of developing dementia: systematic review

    ✓ Peer-reviewed Risk factors The British journal of psychiatry : the journal of mental science

    Key finding: Affective disorders appear to be associated with an increased risk of developing dementia, and one that is dependent on clinical and demographic variables. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2013-03-01

    2013 Alzheimer's disease facts and figures

    ✓ Peer-reviewed How common it is Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: A projected 450,000 older Americans with AD will die in 2013, and a large proportion will die as a result of complications of AD.

    Full summary, score breakdown and related studies → Original source

  21. 2013-03-01

    Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease

    ✓ Peer-reviewed Genetics JAMA neurology

    Key finding: Although there were no significant differences among the 3 groups of participants in their clinical ratings, neuropsychological test scores, hippocampal volumes (P = .60), or hippocampal glucose metabolism measurements (P = .12), there were significant group differences in their posterior cingulate glucose metabolism measurements (P = .001). +1 more finding

    Full summary, score breakdown and related studies → Original source

February 2013 4

  1. 2013-02-28

    Pain relief at the end of life: nurses' experiences regarding end-of-life pain relief in patients with dementia

    ✓ Peer-reviewed End-of-life care Pain management nursing : official journal of the American Society of Pain Management Nurses

    Key finding: The results of this study highlight the complexity of pain relief in patients with dementia at the end of life from a nursing perspective.

    Full summary, score breakdown and related studies → Original source

  2. 2013-02-27

    A population-based study of dosing and persistence with anti-dementia medications

    ✓ Peer-reviewed Treatments European journal of clinical pharmacology

    Key finding: Between January 2006 and December 2010, 20,729 patients aged >70 years received a prescription for an AD medication. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2013-02-27

    Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI

    ✓ Peer-reviewed Genetics Neurology

    Key finding: AD biomarkers are useful to predict AD-type dementia in subjects with aMCI and naMCI. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2013-02-27

    Brain β-amyloid load approaches a plateau

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: This roughly 15-year interval where the slope of the amyloid SUVR vs time curve is greatest and roughly linear represents a large therapeutic window for secondary preventive interventions.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →