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The changing scene of amyotrophic lateral sclerosis
Robberecht W, Philips T.. Nature reviews. Neuroscience, 2013-03-06
Topic: Brain proteins, microglia and lab models
Several recent breakthroughs have provided notable insights into the pathogenesis of amyotrophic lateral sclerosis (ALS), with some even shifting our thinking about this neurodegenerative disease and raising the question as to whether this disorder is a proteinopathy, a ribonucleopathy or both. In addition, these breakthroughs have revealed mechanistic links between ALS and frontotemporal dementia, as well as between ALS and other neurodegenerative diseases, such as the cerebellar atrophies, myotonic dystrophy and inclusion body myositis. Here, we summarize the new findings in ALS research, discuss what they have taught us about this disease and examine issues that are still outstanding.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Robberecht, W., & Philips, T. (2013). The changing scene of amyotrophic lateral sclerosis. Nature reviews. Neuroscience. https://doi.org/10.1038/nrn3430
Vancouver
Robberecht W, Philips T. The changing scene of amyotrophic lateral sclerosis. Nature reviews. Neuroscience. 2013. doi:10.1038/nrn3430. PMID: 23463272.
BibTeX
@article{robberecht2013-23463272,
author = {Robberecht, W. and Philips, T.},
title = {{The changing scene of amyotrophic lateral sclerosis}},
journal = {Nature reviews. Neuroscience},
year = {2013},
doi = {10.1038/nrn3430},
pmid = {23463272},
url = {https://doi.org/10.1038/nrn3430}
}
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Key findings
- In addition, these breakthroughs have revealed mechanistic links between ALS and frontotemporal dementia, as well as between ALS and other neurodegenerative diseases, such as the cerebellar atrophies, myotonic dystrophy and inclusion body myositis.
Why it matters
This review summarizes recent findings on the causes of ALS and notes mechanistic links between ALS and frontotemporal dementia and other neurodegenerative diseases. It discusses what these findings teach about the disease and what questions remain, but it does not report a treatment or cure.
Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nature reviews. Neuroscience) |
| Journal's citation record | 4 / 4 | Nature reviews. Neuroscience: journal h-index 572 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 959 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 63.9 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 4 / 6 | Cited 15.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 81 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Thomas Philips: h-index 13 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23463272) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
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