Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,551–12,575 of 27,380 studies, newest first · page 503 of 1096.
August 2019 25
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2019-08-20
Amyloid-β PET-Correlation with cerebrospinal fluid biomarkers and prediction of Alzheimer´s disease diagnosis in a memory clinic
47/100 ✓ Peer-reviewed Tau biomarkers PloS one
Key finding: Alzheimer's disease (AD) remains a clinical diagnosis but biomarkers from cerebrospinal fluid (CSF) and more lately amyloid imaging with positron emission tomography (PET), are important to support a diagnosis of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-20
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study
71/100 ✓ Peer-reviewed Biomarkers The Lancet. Neurology
Key finding: High and increasing blood pressure from early adulthood into midlife seems to be associated with increased WMHV and smaller brain volumes at 69-71 years of age. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-18
Effect of computerised cognitive training on cognitive outcomes in mild cognitive impairment: a systematic review and meta-analysis
78/100 ✓ Peer-reviewed Prevention trials BMJ open
Key finding: This meta-analysis provides evidence that CCT improves cognitive function in older people with MCI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-08-18
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
51/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Patients with AD and MCI have decreased microbial diversity, and changes in gut microbiota could be detected for early detection of AD.
Full summary, score breakdown and related studies → Original source
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2019-08-17
Souvenaid in the management of mild cognitive impairment: an expert consensus opinion
48/100 ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy
Key finding: Early and accurate diagnosis of MCI provides a window of opportunity to improve the outcomes using a multimodal management approach including lifestyle risk factor modification and consideration of the multinutrient Souvenaid.
Full summary, score breakdown and related studies → Original source
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2019-08-17
Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies
69/100 ✓ Peer-reviewed How common it is Ageing research reviews
Key finding: Diabetes, even prediabetes and changes of diabetes-related biochemical indicators, predicted increased incidence of cognitive impairment and dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-16
Blood NfL: A biomarker for disease severity and progression in Parkinson disease
50/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Plasma NfL levels correlated with disease severity and progression in terms of both motor and cognitive functions in PD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-16
Cognitive dysfunction in diabetes: how to implement emerging guidelines
51/100 ✓ Peer-reviewed Risk factors Diabetologia
Key finding: Cognitive dysfunction, including mild cognitive impairment and dementia, is increasingly recognised as an important comorbidity and complication of diabetes that affects an individual's well-being and diabetes management, and is associated with diabetes treatment-related complications. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-08-16
Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT)
69/100 ✓ Peer-reviewed Treatments Nutrients
Key finding: Low dose ω3-PUFA supplementation, either alone or in combination with a multidomain lifestyle intervention comprising physical activity counselling, had no significant effects on muscle strength over 3 years in elderly people. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-16
Economic impacts of introducing diagnostics for mild cognitive impairment Alzheimer's disease patients
46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)
Key finding: The budgetary impacts are not insignificant but are small in comparison to the likely market price of any disease-modifying treatments or to the probable costs of missed or inaccurate diagnosis.
Full summary, score breakdown and related studies → Original source
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2019-08-14
Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice
41/100 ✓ Peer-reviewed Disease mechanisms Scientific Reports
Key finding: These findings suggest that the suppression of gut dysbiosis and LPS production by NK46 can mitigate cognitive decline through the regulation of microbiota LPS-mediated NF-κB activation.
Full summary, score breakdown and related studies → Original source
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2019-08-14
Research, recruitment and observational data collection in care homes: lessons from the PACE study
44/100 ✓ Peer-reviewed Health systems and care delivery BMC research notes
Key finding: Multiple challenges were encountered in creating a sampling framework and contacting, recruiting and retaining care homes in the PACE study. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-14
Mobility assessment in people with Alzheimer disease using smartphone sensors
55/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neuroengineering and rehabilitation
Key finding: Our findings indicate that AD patients present impairments in some key functional abilities, such as gait, turning and sitting, sit to stand, and reaction time, both in mild and moderate AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-14
Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein
50/100 ✓ Peer-reviewed Risk genes beyond APOE Acta neuropathologica
Key finding: Both lesions develop in parallel in the human brain throughout the preclinical and clinical course of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-14
Cognitive assessment tools for mild cognitive impairment screening
39/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurology
Key finding: However, there is currently no consensus on guidelines for routine screening of MCI, resulting in a considerable number of patients with undiagnosed MCI from community. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-13
Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors
38/100 ✓ Peer-reviewed Tau biomarkers Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Our research group has shown that extracellular levels of both Aβ and tau fluctuate during the normal sleep-wake cycle. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-13
Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease
46/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in computational neuroscience
Key finding: In this work, we demonstrate how computational multi-scale brain modeling links phenomena of different scales and therefore identifies potential disease mechanisms leading the way to improved diagnostics and treatment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-12
Organokines in disease
39/100 ✓ Peer-reviewed Risk factors Advances in clinical chemistry
Key finding: Metabolic syndrome represents comorbidities of central obesity, insulin resistance, dyslipidemia, hypertension and hyperglycemia associated with increased risk of type 2 diabetes, NAFLD, atherosclerotic CVD and neurodegenerative disease.
Full summary, score breakdown and related studies → Original source
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2019-08-12
30-Day Emergency Department Revisit Rates among Older Adults with Documented Dementia
56/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: Dementia diagnoses were a significant predictor of 30-day ED revisits. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-12
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
38/100 ✓ Peer-reviewed Genetics Neuron
Key finding: Familial Alzheimer's disease (fAD) results from mutations in the amyloid precursor protein (APP) and presenilin (PSEN1 and PSEN2) genes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-08-12
Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers
56/100 ✓ Peer-reviewed Biomarkers Annals of neurology
Key finding: D-CAA M + showed greater age-dependent FLR PiB retention (p - , and serially imaged asymptomatic M + demonstrated greater longitudinal increases (p = 0.004). +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-09
Long-term exposure to air pollution and hospitalization for dementia in the Rome longitudinal study
62/100 ✓ Peer-reviewed Risk factors Environmental health : a global access science source
Key finding: Our results showed a positive association between exposure to NOx and O 3 and hospitalization for dementia and a negative association between NO 2 exposure and hospitalization for dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-09
Effect of Linagliptin on Cognitive Performance in Patients With Type 2 Diabetes and Cardiorenal Comorbidities: The CARMELINA Randomized Trial
83/100 ✓ Peer-reviewed Drug development Diabetes care
Key finding: In a large international cardiovascular outcome trial in people with type 2 diabetes and cardiorenal disease, linagliptin did not modulate cognitive decline over 2.5 years. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-08-09
Defining Serious Illness Among Adult Surgical Patients
38/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: We identified a consensus definition for serious illness in surgery. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-08-09
A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
47/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's research & therapy
Key finding: This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. +3 more findings
Full summary, score breakdown and related studies → Original source
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