Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,426–19,450 of 27,380 studies, newest first · page 778 of 1096.
June 2012 17
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2012-06-01
Validity of a brief computerized cognitive screening test in dementia
43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of geriatric psychiatry and neurology
Key finding: CogState and standard neuropsychological task scores were significantly lower for dementia participants than that of the nondementia groups (P < .05), with a single CogState test distinguishing control from MCI participants, but minimal differentiation existing between dementias using the CogState. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-06-01
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
40/100 ✓ Peer-reviewed Tau biomarkers Nature neuroscience
Key finding: Our results suggest that microRNAs can function as signaling molecules and identify TLR7 as an essential element in a pathway that contributes to the spread of CNS damage.
Full summary, score breakdown and related studies → Original source
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2012-06-01
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
40/100 ✓ Peer-reviewed Biomarkers Journal of cellular and molecular medicine
Key finding: Glucose and insulin tolerance tests revealed significant hyperglycaemia in mice overexpressing IGF-2, which was exacerbated by high-fat diet. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Predictive neural biomarkers of clinical response in depression: a meta-analysis of functional and structural neuroimaging studies of pharmacological and psychological therapies
64/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of disease
Key finding: We performed a systematic review and meta-analysis of neural predictors of response to the most commonly used, evidence based treatments in clinical practice, namely pharmacological and psychological therapies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Neurocognitive impairment in obstructive sleep apnea
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Chest
Key finding: Several studies have shown that OSAS has an adverse effect on inductive and deductive reasoning, attention, vigilance, learning, and memory. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-06-01
Drug therapy optimization at the end of life
36/100 ✓ Peer-reviewed End-of-life care Drugs & aging
Key finding: However, discontinuation of drugs is not standard practice, and prescriptions are usually not adapted to changes in the course of advanced diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors
52/100 ✓ Peer-reviewed Prevention trials Journal of the Academy of Nutrition and Dietetics
Key finding: In women at higher risk of cognitive decline due to vascular disease or risk factors, adherence to a Mediterranean-style diet was not associated with subsequent 5-year cognitive change. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-06-01
Overview and Findings from the Rush Memory and Aging Project
47/100 ✓ Peer-reviewed Long-term cohort studies Current Alzheimer Research
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer’s disease (AD).
Full summary, score breakdown and related studies → Original source
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2012-06-01
ENRICH: a new innovation to facilitate dementia research in care homes
25/100 ✓ Peer-reviewed Health systems and care delivery British Journal of Community Nursing
Key finding: There are currently almost three times as many care home beds as NHS hospital beds in England, and the number is projected to rise significantly by 2019 (Laing and Buisson, 2009).
Full summary, score breakdown and related studies → Original source
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2012-06-01
Large femoral heads decrease the incidence of dislocation after total hip arthroplasty: a randomized controlled trial
64/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of bone and joint surgery. American volume
Key finding: The aim of this multicenter randomized controlled trial was to determine whether the incidence of dislocation one year after total hip arthroplasty is significantly lower in association with the use of a 36-mm femoral head articulation as compared with a 28-mm articulation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma
49/100 ✓ Peer-reviewed Brain tissue and pathology Brain imaging and behavior
Key finding: It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and eventually dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Rationale for use of the Clinical Dementia Rating Sum of Boxes as a primary outcome measure for Alzheimer's disease clinical trials
52/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The CDR-SB assesses both cognitive and functional domains of AD disability. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression
59/100 ✓ Peer-reviewed How common it is The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We observed loss of correlations within not only the DMN but other networks at CDR 0.5. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Multicentre population-based dementia prevalence survey in Japan: a preliminary report
45/100 ✓ Peer-reviewed Disparities Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Key finding: In total, 3394 participants were examined (participation rate: 62.5%), and 768 dementia cases and 529 mild cognitive impairment cases were identified. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgery
46/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurosurgery
Key finding: Object The authors describe the first clinical trial with encapsulated cell biodelivery (ECB) implants that deliver nerve growth factor (NGF) to the cholinergic basal forebrain with the intention of halting the degeneration of cholinergic neurons and the associated cognitive decline in patients with Alzheimer disease (AD).
Full summary, score breakdown and related studies → Original source
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2012-06-01
Systematic review of atorvastatin for the treatment of Alzheimer's disease
53/100 ✓ Peer-reviewed Treatments Neural regeneration research
Key finding: Two randomized controlled trials were included, one was scale A, and the other was scale B. The rates of abnormal liver function, withdrawal from treatment, and withdrawal due to adverse effects were higher in the treatment group (OR = 7.86, 95%CI: 2.50-24.69; OR = 4.70, 95%CI: 2.61-8.44; and OR = 5.47, 95%CI: 3.01-9.94; respectively) compared with the placebo group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-01
Celecoxib or naproxen treatment does not benefit depressive symptoms in persons age 70 and older: findings from a randomized controlled trial
63/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Treatment with celecoxib or naproxen did not improve depressive symptoms over time compared with placebo. +4 more findings
Full summary, score breakdown and related studies → Original source
May 2012 8
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2012-05-31
Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations
45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The nuclear factor-κB (NF-κB) is a stress-activated transcription factor that is activated around senile plaques. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-05-30
Older people dying with dementia: a nationwide study
36/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: Several areas of end-of-life care provision could be improved. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-05-30
Screening for cognitive impairment: comparing the performance of four instruments in primary care
48/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: In individuals without a prior diagnosis of cognitive impairment, the prevalence of dementia was low, but the prevalence of CIND was high.
Full summary, score breakdown and related studies → Original source
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2012-05-30
A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study
61/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society
Key finding: A single-question screen for RBD may reliably detect disease, with psychometric properties favorably comparable to those reported for longer questionnaires. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-05-29
Structure and pathology of tau protein in Alzheimer disease
40/100 ✓ Peer-reviewed Disparities International journal of Alzheimer's disease
Key finding: Alterations in the amount or the structure of tau protein can affect its role as a stabilizer of microtubules as well as some of the processes in which it is implicated. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-05-29
Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease
50/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuroinflammation
Key finding: Neuroinflammation is associated with virtually all major neurodegenerative disorders, including Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-05-28
Time to diagnosis in young-onset dementia as compared with late-onset dementia
59/100 ✓ Peer-reviewed Brain tissue and pathology Psychological medicine
Key finding: The extent to which specific factors influence diagnostic delays in dementia is unclear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-05-24
The Lewy body in Parkinson's disease and related neurodegenerative disorders
48/100 ✓ Peer-reviewed Lewy body dementia Molecular neurobiology
Key finding: However, recent studies have indicated that nonfibrillar α-synuclein is cytotoxic and that fibrillar aggregates of α-synuclein (LBs and pale bodies) may represent a cytoprotective mechanism in PD.
Full summary, score breakdown and related studies → Original source
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