Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,551–18,575 of 27,380 studies, newest first · page 743 of 1096.
July 2013 25
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2013-07-12
Which behavioral and psychological symptoms of dementia are the most problematic? Variability by prevalence, intensity, distress ratings, and associations with caregiver depressive symptoms
46/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Symptoms revealed as "most problematic" varied by measurement criterion. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-11
The future of blood-based biomarkers for Alzheimer's disease
40/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably.
Full summary, score breakdown and related studies → Original source
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2013-07-10
Much of late life cognitive decline is not due to common neurodegenerative pathologies
66/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology
Key finding: The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy body disease accumulate in the brains of older persons with and without dementia, but the extent to which they account for late life cognitive decline remains unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-10
Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre
59/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease, but the evidence for their association with other neurodegenerative disorders is limited. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-09
Palliative care for Parkinson's disease: a summary of the evidence and future directions
36/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Despite calls for improved access to palliative care for people with Parkinson's disease, services have been slow in developing. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-09
Molecular mechanisms of cognitive dysfunction following traumatic brain injury
40/100 ✓ Peer-reviewed Disease mechanisms Frontiers in aging neuroscience
Key finding: Traumatic brain injury (TBI) results in significant disability due to cognitive deficits particularly in attention, learning and memory, and higher-order executive functions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-06
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease
40/100 ✓ Peer-reviewed Genetics Acta neuropathologica communications
Key finding: The UPR is activated in disease affected regions in PSP and the genetic evidence shows that this activation increases risk for PSP and is not a protective response. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-05
Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease
49/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: The results suggest that (11)C-PIB binding to Aβ deposits in transgenic mouse brain is highly dependent on the AD model and the structure of its Aβ plaques. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-04
White paper defining optimal palliative care in older people with dementia: a Delphi study and recommendations from the European Association for Palliative Care
43/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: We have provided the first definition of palliative care in dementia based on evidence and consensus, a framework to provide guidance for clinical practice, policy and research.
Full summary, score breakdown and related studies → Original source
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2013-07-04
Higher rates of decline for women and apolipoprotein E epsilon4 carriers
53/100 ✓ Peer-reviewed Brain tissue and pathology AJNR. American journal of neuroradiology
Key finding: Age and the apolipoprotein E ε4 allele are well-known risk factors for Alzheimer disease, but whether female sex is also a risk factor remains controversial. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-04
Frailty and cognitive impairment--a review of the evidence and causal mechanisms
49/100 ✓ Peer-reviewed How common it is Ageing research reviews
Key finding: A number of epidemiological studies have reported that frailty increases the risk of future cognitive decline and that cognitive impairment increases the risk of frailty suggesting that cognition and frailty interact within a cycle of decline associated with ageing.
Full summary, score breakdown and related studies → Original source
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2013-07-03
The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials
74/100 ✓ Peer-reviewed Prevention trials The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: There is very limited evidence that exercise improves cognitive function in individuals with MCI, although published research is of moderate quality and inconclusive due to low statistical power. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-03
Prion-like properties of pathological TDP-43 aggregates from diseased brains
51/100 ✓ Peer-reviewed Lewy body dementia Cell reports
Key finding: Immunoblot analyses revealed that the C-terminal fragments of insoluble TDP-43 characteristic of each disease type acted as seeds, inducing seed-dependent aggregation of TDP-43 in these cells. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-03
A videophone psychosocial intervention for dementia caregivers
57/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: A technology-based format was feasible for delivering a multi-component intervention to minority family dementia caregivers. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-03
Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology
55/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: Clinico-pathological correlation studies and positron emission tomography amyloid imaging studies have shown that some individuals can tolerate substantial amounts of Alzheimer's pathology in their brains without experiencing dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-03
Amyloid PET Imaging in Lewy body disorders
50/100 ✓ Peer-reviewed Biomarkers The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: LB disorders are associated with lower mean cortical Aβ ligand binding compared with Alzheimer disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-02
Care in specialist medical and mental health unit compared with standard care for older people with cognitive impairment admitted to general hospital: randomised controlled trial (NIHR TEAM trial)
79/100 ✓ Peer-reviewed Clinical safety BMJ (Clinical research ed.)
Key finding: There was no significant difference in days spent at home between the specialist unit and standard care groups (median 51 v 45 days, 95% confidence interval for difference -12 to 24; P=0.3). +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-02
Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia
43/100 ✓ Peer-reviewed Clinical safety Acta neuropathologica
Key finding: Overall, the clinical and pathological features were severe, but did not fall outside the usual disease spectrum. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-02
Mediterranean diet adherence and self-reported psychological functioning in an Australian sample
47/100 ✓ Peer-reviewed Prevention trials Appetite
Key finding: Overall MedDiet adherence was not related to cognitive function. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-02
Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models
48/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica
Key finding: Previous work has implicated the perivascular spaces along arteries as the likely route for ISF clearance; however, it has never been demonstrated directly. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
40/100 ✓ Peer-reviewed Inflammation and the immune system Cell Reports
Key finding: We found that SOD1(G93A) microglia are not derived from infiltrating monocytes, and that both potentially neuroprotective and toxic factors, including Alzheimer's disease genes, are concurrently upregulated. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
P4–285: SAR228810: An antiprotofibrillar beta‐amyloid antibody designed to reduce risk of amyloid‐related imaging abnormalities (ARIA)
34/100 ✓ Peer-reviewed Treatments Alzheimer s & Dementia
Key finding: Compared to other anti-A β mAb, SAR228810 does not neutralize soluble Aβ monomers or low molecular weight Aβ complexes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-01
Oxidative stress, mitochondrial damage and neurodegenerative diseases
40/100 ✓ Peer-reviewed Disease mechanisms Neural regeneration research
Key finding: Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Distinct α-synuclein strains differentially promote tau inclusions in neurons
36/100 ✓ Peer-reviewed Brain tissue and pathology Cell
Key finding: Remarkably, we discovered two distinct strains of synthetic α-synuclein fibrils that demonstrated striking differences in the efficiency of cross-seeding tau aggregation, both in neuron cultures and in vivo. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-01
Antisense reduction of tau in adult mice protects against seizures
36/100 ✓ Peer-reviewed Drug development The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Our results demonstrate that endogenous tau is integral for regulating neuronal hyperexcitability in adult animals and suggest that an antisense oligonucleotide reduction of tau could benefit those with epilepsy and perhaps other disorders associated with tau-mediated neuronal hyperexcitability.
Full summary, score breakdown and related studies → Original source
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