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Risk Factors for β-Amyloid Deposition in Healthy Aging
Karen M. Rodrigue, Jenny R Rieck, Kristen M. Kennedy, Michael D. Devous, Ramon R. Diaz-Arrastia, Denise C. Park. JAMA Neurology, 2013-03-18
Topic: Plasma and spinal-fluid biomarkers
Participants in the hypertension group with at least 1 ε4 allele showed significantly greater amyloid burden than those with only 1 risk factor or no risk factors. Furthermore, increased pulse pressure was strongly associated with increased mean cortical amyloid level for subjects with at least 1 ε4 allele. CONCLUSIONS AND RELEVANCE: Vascular disease is a prevalent age-related condition that is highly responsive to both behavioral modification and medical treatment. Proper control and prevention of risk factors such as hypertension earlier in the life span may be one potential mechanism to ameliorate or delay neuropathological brain changes with aging.
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APA 7th
Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R. R., & Park, D. C. (2013). Risk Factors for β-Amyloid Deposition in Healthy Aging. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2013.1342
Vancouver
Rodrigue KM, Rieck JR, Kennedy KM, Devous MD, Diaz-Arrastia RR, Park DC. Risk Factors for β-Amyloid Deposition in Healthy Aging. JAMA Neurology. 2013. doi:10.1001/jamaneurol.2013.1342. PMID: 23553344.
BibTeX
@article{rodrigue2013-23553344,
author = {Rodrigue, Karen M. and Rieck, Jenny R and Kennedy, Kristen M. and Devous, Michael D. and Diaz-Arrastia, Ramon R. and Park, Denise C.},
title = {{Risk Factors for β-Amyloid Deposition in Healthy Aging}},
journal = {JAMA Neurology},
year = {2013},
doi = {10.1001/jamaneurol.2013.1342},
pmid = {23553344},
url = {https://doi.org/10.1001/jamaneurol.2013.1342}
}
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Key findings
- Participants in the hypertension group with at least 1 ε4 allele showed significantly greater amyloid burden than those with only 1 risk factor or no risk factors.
- Furthermore, increased pulse pressure was strongly associated with increased mean cortical amyloid level for subjects with at least 1 ε4 allele.
- CONCLUSIONS AND RELEVANCE: Vascular disease is a prevalent age-related condition that is highly responsive to both behavioral modification and medical treatment.
- Proper control and prevention of risk factors such as hypertension earlier in the life span may be one potential mechanism to ameliorate or delay neuropathological brain changes with aging.
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Study details
- Study designcross-sectional
- Evidence strengthLow
How this study scored 50/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 29 of the 58 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23553344) |
| Free to read | 2 / 2 | Free to read |
| Points | 29 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 29 of the 58 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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