Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,051–25,075 of 27,380 studies, newest first · page 1003 of 1096.
November 2001 3
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2001-11-01
The role of TNF and its receptors in Alzheimer's disease
42/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: Several TNF promoter polymorphisms that increase expression are associated with inflammatory and infectious diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-11-01
Cotton wool plaques in non-familial late-onset Alzheimer disease
39/100 ✓ Peer-reviewed Biomarkers Journal of neuropathology and experimental neurology
Key finding: We describe a case of sporadic late-onset AD with numerous neocortical CWP as well as severe amyloid angiopathy and marked leukoencephalopathy, compared with 16 cases of late-onset AD with similar degrees of amyloid angiopathy and leukoencephalopathy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-11-01
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
54/100 ✓ Peer-reviewed Biomarkers The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of these mice. +1 more finding
Full summary, score breakdown and related studies → Original source
October 2001 22
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2001-10-17
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
47/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry
Key finding: In the splice isoforms lacking exon 10, this process is facilitated by the formation of beta-structure around the hexapeptide motif PHF6 ((306)VQIVYK(311)) encoded by exon 11. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-16
ACOVE Quality Indicators
67/100 ✓ Peer-reviewed End-of-life care Annals of Internal Medicine
Key finding: Miles, MD, PhDComparison of Administrative Data and Medical Records to Measure the Quality of Medical Care Provided to Vulnerable Older PatientsNational Adherence to Evidence-Based Guidelines for the Prescription of Nonsteroidal Anti-Inflammatory DrugsPredictors of Overall Quality of Care Provided to Vulnerable Older PeopleQuality of Care Is Associated with Survival in Vulnerable Older PatientsTakahiro Higashi, MD, PhD, Paul G.
Full summary, score breakdown and related studies → Original source
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2001-10-16
Assessing Care of Vulnerable Elders: ACOVE Project Overview
76/100 ✓ Peer-reviewed End-of-life care Annals of Internal Medicine
Key finding: Such targeted approaches may not present a fair picture of overall quality and may lead to unintended incentives ("gaming the system") (7). +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-09
Deaths: preliminary data for 2000
36/100 ✓ Peer-reviewed Disparities PubMed
Key finding: The age-adjusted death rate for the United States decreased from 832.7 deaths per 100,000 population in 2003 to 801.0 deaths per 100,000 population in 2004. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-02
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: Chronic psychosocial stress significantly decreased in vivo concentrations of N-acetyl-aspartate (-13%), creatine and phosphocreatine (-15%), and choline-containing compounds (-13%). +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-10-01
Annual Incidence of Alzheimer Disease in the United States Projected to the Years 2000 Through 2050
36/100 ✓ Peer-reviewed Risk factors Alzheimer Disease & Associated Disorders
Key finding: Education adjusted age-specific incidence rates of clinically diagnosed probable AD were obtained from stratified random samples of residents 65 years of age and older in a geographically defined community. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis
36/100 ✓ Peer-reviewed Vascular contributions Journal of molecular biology
Key finding: Amyloid beta-protein (Abeta) assembly into toxic oligomeric and fibrillar structures is a seminal event in Alzheimer's disease, therefore blocking this process could have significant therapeutic benefit. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
GSK3 takes centre stage more than 20 years after its discovery
36/100 ✓ Peer-reviewed Risk factors The Biochemical journal
Key finding: The substrate specificity of GSK3 is unusual in that efficient phosphorylation of many of its substrates requires the presence of another phosphorylated residue optimally located four amino acids C-terminal to the site of GSK3 phosphorylation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Procreative beneficence: why we should select the best children
36/100 ✓ Peer-reviewed Brain scans and imaging Bioethics
Key finding: Once the decision to have IVF is made, PGD has few 'costs' to couples, and people would be more inclined to use it to select less serious medical traits, such as a lower risk of developing Alzheimer Disease, or even for non-medical traits.
Full summary, score breakdown and related studies → Original source
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2001-10-01
Morphological and functional retinal impairment in Alzheimer's disease patients
36/100 ✓ Peer-reviewed Biomarkers Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Key finding: Our results suggest that in AD patients, there is a reduction of NFL thickness evaluated in vivo by OCT and this morphological abnormality is related to a retinal dysfunction as revealed by abnormal PERG responses. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Poststroke dementia: incidence and relationship to prestroke cognitive decline
43/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: The risk of PSD is high, and increased in patients with prestroke cognitive decline, with about one-third of patients meeting the criteria for AD and two-thirds meeting the criteria for VaD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-10-01
Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: Different patterns of regional brain atrophy were found among patients of different APOE genotypes.
Full summary, score breakdown and related studies → Original source
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2001-10-01
Scales for evaluation of End-of-Life Care in Dementia
36/100 ✓ Peer-reviewed End-of-life care Alzheimer disease and associated disorders
Key finding: Systematic evaluation of end-of-life care in dementia has been hampered by a lack of instruments to specifically address those issues that are unique for persons who are dying with dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Random Forests
53/100 ✓ Peer-reviewed Cognitive tests and assessment Machine Learning
Full summary, score breakdown and related studies → Original source
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2001-10-01
A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
52/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine
Key finding: However, the DAP12-associated receptors expressed on DCs and their functions have not been identified yet. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
New frontiers in Alzheimer's disease genetics
50/100 ✓ Peer-reviewed Risk genes beyond APOE Neuron
Key finding: Over 100 rare, highly penetrant mutations have been described in three genes (APP, PSEN1, PSEN2) for early-onset familial AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease
52/100 ✓ Peer-reviewed Lewy body dementia Neurology
Key finding: Assessment of the clinical features suggests that an accuracy of 90% may be the highest that can be expected using current diagnostic criteria.
Full summary, score breakdown and related studies → Original source
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2001-10-01
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
55/100 ✓ Peer-reviewed Lewy body dementia Nature medicine
Key finding: The absence of Lewy bodies in patients with parkin mutations suggests that parkin might be required for the formation of Lewy bodies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22
45/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: Hereditary frontotemporal dementia (FTD) is an autosomal dominant neurodegenerative disorder that is associated with mutations in the tau gene and with the pathological accumulation of hyperphosphorylated tau protein in affected brain cells in about a quarter of cases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-10-01
Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort
58/100 ✓ Peer-reviewed How common it is American journal of epidemiology
Key finding: Research on the relation between diabetes mellitus and dementia has produced conflicting results, and the relation has not been investigated among Blacks and Hispanics. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Problems and issues with door-to-door, two-phase surveys: an illustration from central Spain
41/100 ✓ Peer-reviewed Disparities Neuroepidemiology
Key finding: In 1994-1995, a screening and examination survey was conducted to ascertain the prevalence of dementia, Parkinson's disease and stroke in two urban communities and one rural community of central Spain. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
Frequency of Alzheimer's disease and other dementias in a community outreach sample of Hispanics
45/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Subjects were poor, with low acculturation levels despite long years of U.S. residence. +1 more finding
Full summary, score breakdown and related studies → Original source
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