Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,051–20,075 of 27,380 studies, newest first · page 803 of 1096.
July 2011 11
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2011-07-01
Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)
49/100 ✓ Peer-reviewed Lewy body dementia Journal of molecular neuroscience : MN
Key finding: PiD is the least common FTLD-tau characterized by neuronal Pick bodies in a stereotypic neuroanatomical distribution. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-01
Improving Alzheimer's disease diagnosis with machine learning techniques
42/100 ✓ Peer-reviewed Digital health tools Clinical EEG and neuroscience
Key finding: Therefore, new approaches are necessary to enable earlier and more accurate diagnosis and to follow treatment results. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-01
Patterns and trends in antipsychotic prescribing for Parkinson disease psychosis
49/100 ✓ Peer-reviewed Disparities Archives of neurology
Key finding: In FY2008, 50% of patients with PD having a diagnosis of psychosis were prescribed an AP. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-01
AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America
57/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage
Key finding: The ADNI cohort was used as a replication dataset to validate the model created for the AddNeuroMed cohort and vice versa. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-01
Neuropathology underlying clinical variability in patients with synucleinopathies
70/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica
Key finding: In PD, recent meta-analyses have identified four main clinical phenotypes, and clinicopathological correlations suggest that more severe and more rapid progression of pathology with chronological age, as well as the involvement of additional neuropathologies, differentiates these phenotypes.
Full summary, score breakdown and related studies → Original source
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2011-07-01
Diversity and disparity in dementia: the impact of ethnoracial differences in Alzheimer disease
47/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer disease and associated disorders
Key finding: Debate exists regarding differences in the prevalence of Alzheimer disease (AD) in African Americans and Hispanics in the United States, with some evidence suggesting that the prevalence of AD may be considerably higher in these groups than in non-Hispanic whites. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-07-01
Assessment of cognition using surveys and neuropsychological assessment: the Health and Retirement Study and the Aging, Demographics, and Memory Study
53/100 ✓ Peer-reviewed Getting a diagnosis The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: Cognitive assessment appropriate for diagnosis of dementia and CIND in large population surveys could be improved with more targeted information from informants and additional cognitive tests targeting other areas of brain function.
Full summary, score breakdown and related studies → Original source
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2011-07-01
Does vigorous exercise have a neuroprotective effect in Parkinson disease?
51/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: Increasing evidence suggests that ongoing vigorous exercise/physical fitness may favorably influence this progression. +4 more findings
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2011-07-01
Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression
59/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Individuals with AD and VaD have higher Hct levels than controls; however, a causal relationship between high-Hct level and risk of developing dementia is not supported. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-01
PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease
67/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: Ten weeks of treatment with PF-04494700 was safe and well tolerated in patients with mild-to-moderate Alzheimer disease, indicating the feasibility of a larger long-term efficacy trial. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-01
Extended results of the Alzheimer's disease anti-inflammatory prevention trial
73/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: These data suggest a revision of the original ADAPT hypothesis that NSAIDs reduce AD risk, as follows: NSAIDs have an adverse effect in later stages of AD pathogenesis, whereas asymptomatic individuals treated with conventional NSAIDs such as naproxen experience reduced AD incidence, but only after 2 to 3 years. +4 more findings
Full summary, score breakdown and related studies → Original source
June 2011 14
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2011-06-29
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
58/100 ✓ Peer-reviewed Genetics Science Translational Medicine
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2011-06-28
Equity in the delivery of community healthcare to older people: findings from 10/66 Dementia Research Group cross-sectional surveys in Latin America, China, India and Nigeria
71/100 ✓ Peer-reviewed Disparities BMC health services research
Key finding: Variation in service use among sites was most plausibly accounted for by stark differences in the extent of out-of-pocket expenses, and the ability of older people and their families to afford them. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-25
Costs of care for dementia patients in community setting: an analysis for mild and moderate disease stage
67/100 ✓ Peer-reviewed Digital health tools Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Key finding: Due to valued informal care, costs of care for community-living patients with moderate dementia are significantly higher than for patients with mild dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-25
Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype
47/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: The largest number of significant, differentially expressed genes were identified when the expression profile of astrocytes from isocortical stages of neurofibrillary tangle pathology (Braak stages V-VI) were compared with entorhinal stages (Braak stages I-II). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-22
Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease
57/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Asymptomatic Aβ deposition in older adults is strongly associated with LMH. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-22
Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease
46/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Despite accumulating amyloid burden, cholinergic enzyme activity is stable in the precuneus during prodromal AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-21
Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia
51/100 ✓ Peer-reviewed Mild cognitive impairment Trends in neurosciences
Key finding: At the time of clinical manifestation of dementia, significant irreversible brain damage is already present, rendering the diagnosis of AD at early stages of the disease an urgent prerequisite for therapeutic treatment to halt, or at least slow, disease progression.
Full summary, score breakdown and related studies → Original source
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2011-06-20
Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
36/100 ✓ Peer-reviewed Treatments Proceedings of the National Academy of Sciences of the United States of America
Key finding: Concomitant reduction in the levels of Aβ and activated complement components in sub-RPE deposits and structural preservation of the RPE are associated with anti-Aβ40/42 antibody immunotherapy and visual protection.
Full summary, score breakdown and related studies → Original source
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2011-06-19
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
53/100 ✓ Peer-reviewed Genetics Nature genetics
Key finding: Environmental causes of tauopathies include repetitive head trauma associated with some sports. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-06-17
Segmentation of the mouse hippocampal formation in magnetic resonance images
52/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: The hippocampal formation plays an important role in cognition, spatial navigation, learning, and memory. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-17
Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis
69/100 ✓ Peer-reviewed Risk factors Injury
Key finding: Whilst there is no conclusive evidence of the preoperative predictors for mortality following hip fractures, special attention should be paid to the above 12 strong evidence predictors. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-16
Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study
64/100 ✓ Peer-reviewed Hippocampus size on brain scans Diabetes care
Key finding: Metabolic dysregulation, especially insulin resistance, was associated with lower brain volumes and executive function in a large, relatively healthy, middle-aged, community-based cohort. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-16
Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement
48/100 ✓ Peer-reviewed Genetics American journal of human genetics
Key finding: We sequenced 33 of these and observed a large expansion of an intronic GGCCTG hexanucleotide repeat in NOP56 and an unregistered missense variant (Phe265Leu) in C20orf194, but we found no mutations in PDYN and TGM6. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-15
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating
40/100 ✓ Peer-reviewed Disease mechanisms PloS one
Key finding: To understand the relationship between tau pathology and behavioral impairments, we comprehensively assessed behavioral abnormalities in a mouse tauopathy model expressing the human P301S mutant tau protein in the early stage of disease to detect its initial neurological manifestations. +4 more findings
Full summary, score breakdown and related studies → Original source
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