Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,676–18,700 of 27,380 studies, newest first · page 748 of 1096.
May 2013 25
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2013-05-17
The impact of early dementia diagnosis and intervention on informal caregivers
48/100 ✓ Peer-reviewed Caregiving Progress in neurobiology
Key finding: However, there still exist a gap between the improved possibilities to diagnose people in the predementia stage versus the scarce knowledge on intervention effects in this very early stage.
Full summary, score breakdown and related studies → Original source
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2013-05-16
The amyloid precursor protein: a biochemical enigma in brain development, function and disease
45/100 ✓ Peer-reviewed Risk genes beyond APOE FEBS letters
Key finding: However, no new therapeutic agents have reached the clinic through exploitation of the hypothesis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-15
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Nature reviews. Neuroscience
Key finding: Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2013-05-13
Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial
78/100 ✓ Peer-reviewed Prevention and risk Journal of neurology, neurosurgery, and psychiatry
Key finding: An intervention with MedDiets enhanced with either EVOO or nuts appears to improve cognition compared with a low-fat diet. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-12
Odor identification deficit predicts clinical conversion from mild cognitive impairment to dementia due to Alzheimer's disease
53/100 ✓ Peer-reviewed Mild cognitive impairment Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Key finding: In a logistic regression model, a lower score in MMSE (95%, OR 1.9; IC 1.23-3.01; p = .004) and a pathological smell identification at baseline (95%, OR 5.1; IC 1.16-22.6; p = .03) were independently associated with the progression to dementia within 2 years.
Full summary, score breakdown and related studies → Original source
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2013-05-10
Combined prevalence of frailty and mild cognitive impairment in a population of elderly Japanese people
56/100 ✓ Peer-reviewed How common it is Journal of the American Medical Directors Association
Key finding: Using the OSHPE criteria, we found more participants with MCI than with frailty. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-09
Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease
40/100 ✓ Peer-reviewed Treatments Neurotoxicity research
Key finding: Both drug types have shown significant efficacy as monotherapies for the treatment of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-09
Recurrent seizures, progressive cognitive decline, Parkinsonism and a calcified brain: is it Fahr's disease?
27/100 ✓ Peer-reviewed Risk factors BMJ Case Reports
Key finding: He had generalised rigidity and mild bilateral symmetrical resting tremor. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-08
Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination
41/100 ✓ Peer-reviewed Genetics The New England journal of medicine
Key finding: The syndrome of hypogonadotropic hypogonadism, ataxia, and dementia can be caused by inactivating mutations in RNF216 or by the combination of mutations in RNF216 and OTUD4. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-05-07
Aberrant functional organization within and between resting-state networks in AD
38/100 ✓ Peer-reviewed Brain scans and imaging PloS one
Key finding: Importantly, we found decreased inter-network connectivity between the visual network and the LFP and between the anterior and posterior DMNs in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-05-04
Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease
62/100 ✓ Peer-reviewed Tau biomarkers Acta neuropathologica
Key finding: In addition, alterations of the levels of total tau, phosphorylated tau [181P], and amyloid beta 1-42 in cerebrospinal fluid have been reported in patients with sporadic Parkinson disease and asymptomatic carriers of leucine-rich repeat kinase 2 mutations, in patterns that clearly differ from those typically described for patients with Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-03
'She's usually quicker than the calculator': financial management and decision-making in couples living with dementia
36/100 ✓ Peer-reviewed End-of-life care Health & social care in the community
Key finding: Thematic analysis of the data showed that social factors influenced the perceived capacity of people with dementia and the financial practices adopted by the couples. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-05-03
Application of the National Institute on Aging-Alzheimer's Association AD criteria to ADNI
52/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: A large proportion of subjects with AD dementia in ADNI may be categorized more definitively as high-probability AD using the proposed biomarker scheme in the NIA-AA criteria. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-02
Implications of early treatment among Medicaid patients with Alzheimer's disease
43/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Earlier treatment leads to a small delay in institutionalization among AD patients, resulting in significant costs savings to Medicaid. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-02
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals
40/100 ✓ Peer-reviewed Drug development Cell death & disease
Key finding: Recent studies have shown that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction or dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-01
Acetylcholinesterase inhibitors: pharmacology and toxicology
40/100 ✓ Peer-reviewed Treatments Current neuropharmacology
Key finding: In the case of reversible inhibitors being commonly applied in neurodegenerative disorders treatment, special attention is paid to currently approved drugs (donepezil, rivastigmine and galantamine) in the pharmacotherapy of Alzheimer's disease, and toxic carbamates used as pesticides. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-01
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"
41/100 ✓ Peer-reviewed Treatments Science (New York, N.Y.)
Key finding: (Reports, 23 March 2012, p. 1503; published online 9 February 2012) tested bexarotene as a potential β-amyloid-lowering drug for Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-01
Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population
57/100 ✓ Peer-reviewed Vascular contributions Sleep
Key finding: Measurements and results Participants underwent 1-night polysomnography and were classified as no OSA (obstructive apnea-hypopnea index [AHI] < 5, n = 289), mild OSA (AHI 5-15, n = 161), and moderate to severe OSA (AHI ≥ 15, n = 53). +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-05-01
Increased risk of dementia in patients with mild traumatic brain injury: a nationwide cohort study
52/100 ✓ Peer-reviewed Vascular contributions PloS one
Key finding: TBI is an independent significant risk factor of developing dementia even in the mild type. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-01
Determinants of place of death: a population-based retrospective cohort study
43/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: Information on determinants of place of death can inform public health policy regarding care at the end of life and make resource allocation more efficient. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-01
Lifestyle change and the prevention of cognitive decline and dementia: what is the evidence?
36/100 ✓ Peer-reviewed Prevention trials Current opinion in psychiatry
Key finding: Epidemiological work has, however, identified modifiable lifestyle factors, such as poor diet and physical and cognitive inactivity, that are associated with the risk of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-05-01
A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults
76/100 ✓ Peer-reviewed Prevention trials PloS one
Key finding: Visual speed of processing training delivered on-site or at-home to middle-aged or older adults using standard home computers resulted in stabilization or improvement in several cognitive function tests.
Full summary, score breakdown and related studies → Original source
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2013-05-01
Sleep quality and preclinical Alzheimer disease
67/100 ✓ Peer-reviewed Brain tissue and pathology JAMA neurology
Key finding: Sleep and circadian problems are very common in Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-01
Normative values of cognitive and physical function in older adults: findings from the Irish Longitudinal Study on Ageing
53/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: Data were used from the first wave of The Irish Longitudinal Study on Ageing (TILDA), a prospective cohort study that includes a comprehensive health assessment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-05-01
Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults
44/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology
Key finding: The University of Minnesota Medical School in Minneapolis, Minnesota, and the Salhgrenska University Hospital, Sweden. +3 more findings
Full summary, score breakdown and related studies → Original source
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