Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,376–18,400 of 27,380 studies, newest first · page 736 of 1096.
October 2013 16
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2013-10-01
Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects
76/100 ✓ Peer-reviewed Drug development Mayo Clinic proceedings
Key finding: In patients without baseline cognitive dysfunction, short-term data are most compatible with no adverse effect of statins on cognition, and long-term data may support a beneficial role for statins in the prevention of dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors
36/100 ✓ Peer-reviewed Genetics Current Alzheimer research
Key finding: Epidemiologic researches revealed that genetic factors played a decisive role in the development of both early-onset AD (EOAD) and late-onset AD (LOAD).
Full summary, score breakdown and related studies → Original source
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2013-10-01
Cerebrospinal fluid secretion by the choroid plexus
36/100 ✓ Peer-reviewed Tau biomarkers Physiological reviews
Key finding: Significant emphasis is placed on the concept of isotonic fluid transport across epithelia, as there is still surprisingly little consensus on the basic biophysics of this phenomenon.
Full summary, score breakdown and related studies → Original source
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2013-10-01
Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: Phenotypic expression of psychopathology may be strongly influenced by exposure to maltreatment, leading to a constellation of ecophenotypes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
What is family-centered care for nursing home residents with advanced dementia?
43/100 ✓ Peer-reviewed End-of-life care American journal of Alzheimer's disease and other dementias
Key finding: Family members of NH residents (N = 16) with advanced dementia participated in semistructured qualitative interviews that inquired about overall NH experience, communication, surrogate decision making, emotional reaction, and recommendations for improvement.
Full summary, score breakdown and related studies → Original source
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2013-10-01
Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials
36/100 ✓ Peer-reviewed End-of-life care Aging and disease
Key finding: Numerous clinical trials have so far been unable to identify another neuroprotective agent. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
Longitudinal differences in cognitive functioning among older adults with and without heart failure
62/100 ✓ Peer-reviewed Prevention trials Journal of aging and health
Key finding: The results indicate that cognitive difficulties in memory and speed may occur prior to a HF diagnosis, while those with HF may experience steeper declines in reasoning as measured by word series test. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-10-01
Plasma proteomics for the identification of Alzheimer disease
58/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer disease and associated disorders
Key finding: Significant proteins to differentiate between the CON and AD dementia groups were identified in a comprehensive panel of 107 plasma analytes in the training sample; the accuracy in differentiating these 2 groups was explored in the test sample. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
Priority issues in women's mental health
31/100 ✓ Peer-reviewed Risk factors World Psychiatry
Key finding: The role of primary health care has been studied in several sites and the results are promising, with an emphasis on the usefulness of community support and non-pharmacological interventions 10, 11. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
Balancing Burdens and Benefits: Ethical Issues of Off‐Label Prescription Pharmaceutical Use
49/100 ✓ Peer-reviewed Health systems and care delivery PM&R
Key finding: He has even given a threshold outlining when the practice of medicine ends versus when the practice of unethical, non–institutional review board approved research begins. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
53/100 ✓ Peer-reviewed Lewy body dementia Science translational medicine
Key finding: No significant loss of C9ORF72 expression was observed, and knockdown of the transcript was not toxic to cultured human motor neurons. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
57/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: Induced pluripotent stem cell (iPSC)-differentiated neurons from C9ORF72 ALS patients revealed disease-specific (1) intranuclear GGGGCCexp RNA foci, (2) dysregulated gene expression, (3) sequestration of GGGGCCexp RNA binding protein ADARB2, and (4) susceptibility to excitotoxicity.
Full summary, score breakdown and related studies → Original source
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2013-10-01
Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity
51/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology
Key finding: Both Aβ and tau pathology affect default mode network integrity before clinical onset of Alzheimer disease.
Full summary, score breakdown and related studies → Original source
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2013-10-01
Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials
80/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: During the CEE plus MPA intervention phase, the numbers of CHD cases were 196 for CEE plus MPA vs 159 for placebo (hazard ratio [HR], 1.18; 95% CI, 0.95-1.45) and 206 vs 155, respectively, for invasive breast cancer (HR, 1.24; 95% CI, 1.01-1.53). +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
Effects of memantine on clinical ratings, fluorodeoxyglucose positron emission tomography measurements, and cerebrospinal fluid assays in patients with moderate to severe Alzheimer dementia: a 24-week, randomized, clinical trial
56/100 ✓ Peer-reviewed Treatments Journal of clinical psychopharmacology
Key finding: In comparison with the placebo group, the memantine treatment group had significantly less cognitive decline on the Severe Impairment Battery and significantly less CMRgl declines in regions preferentially affected by AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-10-01
Effect of cognitive reserve markers on Alzheimer pathologic progression
55/100 ✓ Peer-reviewed Genetics Alzheimer disease and associated disorders
Key finding: These findings remained unchanged after accounting for APOE 4, longitudinal missing data, and baseline cognitive performance.
Full summary, score breakdown and related studies → Original source
September 2013 9
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2013-09-28
Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: a systematic review of the literature
61/100 ✓ Peer-reviewed How common it is Dementia and geriatric cognitive disorders extra
Key finding: Key message Extensive variation was observed in conversion rates due to the population sampled, diagnostic criteria, and duration, and because many studies did not account for loss to follow-up. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-27
Gait speed in Parkinson disease correlates with cholinergic degeneration
59/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: Comorbid cortical cholinergic denervation is a more robust marker of slowing of gait in PD than nigrostriatal denervation alone. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-27
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage
48/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Recently, TREM2 variants have been shown to be linked to late onset Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-26
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
36/100 ✓ Peer-reviewed Drug development Neuron
Key finding: They also suggest that immunotherapy specifically designed to block trans-cellular aggregate propagation will be a productive treatment strategy.
Full summary, score breakdown and related studies → Original source
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2013-09-25
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
67/100 ✓ Peer-reviewed Genetics Human Molecular Genetics
Key finding: Our results highlight cell adhesion pathways as important in Tau toxicity and AD susceptibility and demonstrate the power of model organism genetic screens for the functional follow-up of human GWAS.
Full summary, score breakdown and related studies → Original source
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2013-09-25
Benzoate, a D-amino acid oxidase inhibitor, for the treatment of early-phase Alzheimer disease: a randomized, double-blind, placebo-controlled trial
64/100 ✓ Peer-reviewed Treatments Biological psychiatry
Key finding: Sodium benzoate substantially improved cognitive and overall functions in patients with early-phase AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-24
Maternal anxiety and infants' hippocampal development: timing matters
48/100 ✓ Peer-reviewed Hippocampus size on brain scans Translational psychiatry
Key finding: Regression analyses showed that antenatal maternal anxiety did not influence bilateral hippocampal volume at birth.
Full summary, score breakdown and related studies → Original source
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2013-09-23
The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives
36/100 ✓ Peer-reviewed Risk genes beyond APOE Biochimica et biophysica acta
Key finding: This hypothesis maintains that gene inheritance defines an individual's baseline mitochondrial function; inherited and environmental factors determine rates at which mitochondrial function changes over time; and baseline mitochondrial function and mitochondrial change rates influence AD chronology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-09-23
Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials
66/100 ✓ Peer-reviewed Cognitive tests and assessment PloS one
Key finding: Huperzine A is a Chinese herb extract used for Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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