Newest studies

RNA Isoform Diversity in Human Neurodegenerative Diseases

43/100 ✓ Peer-reviewed Genetics eNeuro

Key finding: Single-nucleus RNA-sequencing (snRNA-seq) has revealed new levels of cellular organization and diversity within the human brain. +2 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis

49/100 ✓ Peer-reviewed TREM2 and immune genetics Developmental cell

Key finding: The death of foamy macrophages is a main contributor to plaque progression, but the underlying mechanisms remain unclear. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Blood-Based Biomarkers and Risk of Onset of Mild Cognitive Impairment Over the Short and Long Term

65/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: This study examined whether levels of blood biomarkers of amyloid (Aβ 42 /Aβ 40 ratio), tau (p-tau 181 ), neurodegeneration (NfL), and glial activation and neuroinflammation (glial fibrillary acidic protein [GFAP], YKL40, soluble triggering receptor expressed on myeloid cells 2 [sTREM2]) collected when participants were cognitively normal are associated with the time to onset of MCI. +4 more findings

• Biomarkers
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Shared Genetic Architecture Between COVID-19 Severity and Alzheimer's Disease Across European and African Ancestries

16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research square

Key finding: The global outbreak of COVID-19, caused by the SARS-CoV-2 virus, has been linked to long-term neurological complications, including an increased risk of Alzheimer's disease (AD) among older adults. +3 more findings

• Genetics

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial

80/100 ✓ Peer-reviewed Prevention trials BMC medicine

Key finding: The intervention was feasible and acceptable with the intended number of participants completing the study. +4 more findings

• Clinical Trials
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Accumulated BCAAs and BCKAs contribute to the HFD-induced deterioration of Alzheimer's disease via a dysfunctional TREM2-related reduction in microglial β-amyloid clearance

43/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

Key finding: We found that BCAAs and BCKAs could bind to TREM2 in silico, in pure protein solutions and in the cellular environment. +1 more finding

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Comparison of Plasma p-tau217 and [18F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia

54/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Our study provides evidence that plasma p-tau217 has strong discriminative accuracy for AD among patients with early-onset and/or atypical dementia assessed in specialized settings. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Anti-diabetic agents and the risks of dementia in patients with type 2 diabetes: a systematic review and network meta-analysis of observational studies and randomized controlled trials

65/100 ✓ Peer-reviewed Prevention and risk Alzheimer's Research & Therapy

Key finding: Compared with non-users, SGLT-2i, GLP-1RA, TZD and metformin were associated with the reduced risk of dementia in patients with T2D. SGLT-2i, and GLP-1RA may serve as the optimal choice to improve the cognitive prognosis in patients with T2D. +4 more findings

• Risk Factors
• Clinical Trials
• Prevention

Full summary, score breakdown and related studies → Original source

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): Executive summary of recommendations for primary care

70/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & Dementia

Key finding: If clinicians use this guideline and health-care systems provide adequate resources, outcomes should improve in most patients in most practice settings. +4 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis

77/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: 30 studies, 9,787 individuals pooled across 10 countries +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials

46/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to optimize and validate biomarkers for clinical trials while sharing all data and biofluid samples with the global scientific community. +1 more finding

• Treatments
• Clinical Trials
• Biomarkers

Full summary, score breakdown and related studies → Original source

Progress in reducing mortality from 10 major causes by county poverty level, from 1990-1994 to 2016-2020, in the US

31/100 ✓ Peer-reviewed Risk factors Med (New York, N.Y.)

Key finding: Overall death rates in the US have been declining in the past few decades.

Full summary, score breakdown and related studies → Original source

Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Higher plasma p-tau181 level was associated with worse memory, executive functioning, and language abilities, and greater informant-reported SCD. +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Cerebrospinal Fluid Classical Biomarker Levels in Mixed vs. Pure A+T+ (A+T1+) Alzheimer's Disease

41/100 ✓ Peer-reviewed Tau biomarkers Biomedicines

Key finding: Alzheimer's disease (AD) may present with pure (typical or atypical) and mixed phenotypes, sometimes causing difficulties in (differential) diagnosis. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

18F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease

54/100 ✓ Peer-reviewed Brain scans and imaging Brain communications

Key finding: A subset of participants received cognitive testing and/or the Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III motor exam (off medication). 18F-PI-2620 uptake was low overall in Lewy body disease and correlated with β-amyloid PET in temporal lobe regions and precuneus. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia: New Insights from Single-Cell and Spatial Transcriptomics

43/100 ✓ Peer-reviewed Genetics The American journal of pathology

Key finding: Neurodegenerative diseases, including Alzheimer disease, frontotemporal dementia, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis, are often casually linked to protein aggregation and inclusion. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Analytical and clinical performance of eight Simoa® and Lumipulse® assays for automated measurement of plasma p-tau181 and p-tau217

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: We found a strong, positive correlation between all the measurements. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Intracerebral hemorrhage following mild ARIA-H in an APOE ε2 carrier receiving lecanemab

50/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: Although APOE ε2 is known to be protective against Alzheimer's disease, it has also been shown to increase risk for hemorrhage with cerebral amyloid angiopathy.

• Treatments
• Side Effects
• Genetics

Full summary, score breakdown and related studies → Original source

Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries

41/100 ✓ Peer-reviewed Health systems and care delivery Neurology and Therapy

Key finding: In FFS, AD incidence (2008-2018) decreased (138 to 104); MCI incidence increased (8 to 47), but the sum (MCI + AD) was relatively stable (146 to 151). +4 more findings

• Risk Factors
• Policy

Full summary, score breakdown and related studies → Original source

Single-cell RNA sequencing-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma

59/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of hepatology

Key finding: & aims The combination of atezolizumab and bevacizumab (atezo+bev) is the current standard of care for advanced hepatocellular carcinoma (HCC), providing a median overall survival (OS) of 19.2 months. +3 more findings

Full summary, score breakdown and related studies → Original source

Exploring the Relationship between Dietary Patterns and Mental Health

28/100 ✓ Peer-reviewed Risk factors Journal of Scientific Research and Reports

Key finding: For example, in patients with depression, markers of systemic inflammation are often significantly greater than in controls, which is indicative of immune system dysregulation. +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Disentangling relationships between Alzheimer's disease plasma biomarkers and established biomarkers in patients of tertiary memory clinics

50/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: Although plasma pTau181, pTau217, pTau231, and GFAP were significantly associated with both Aβ-PET and CSF pTau181, Aβ-PET explained more variance in the levels of these biomarkers. +3 more findings

• Biomarkers
• Brain Scans
• Care Services

Full summary, score breakdown and related studies → Original source

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

46/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The same vulnerable inhibitory neuron subtype was depleted in both AD and DLB. +4 more findings

Full summary, score breakdown and related studies → Original source

An innovative model of behavioral healthcare for older adults with serious mental illness, substance use disorders, and dementia

42/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: A total of 2301 patients completed an intake from January 2023 to March 2024. +4 more findings

Full summary, score breakdown and related studies → Original source

Posterior Cortical Atrophy Due to Alzheimer Disease in a Person With Down Syndrome: A Case Report

45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

Key finding: This well-characterized case of PCA syndrome due to AD in a very young patient with DS demonstrates the occurrence of atypical presentations in DS that might be overshadowed by the baseline intellectual disability associated with DS. +4 more findings

• Down Syndrome
• Brain Scans

Full summary, score breakdown and related studies → Original source