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Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity
Wang L, Brier MR, Snyder AZ, Thomas JB, Fagan AM, Xiong C, Benzinger TL, Holtzman DM et al.. JAMA neurology, 2013-10-01
Topic: Brain proteins, microglia and lab models
Importance Resting-state functional connectivity magnetic resonance imaging has great potential for characterizing pathophysiological changes during the preclinical phase of Alzheimer disease. Objective To assess the relationship between default mode network integrity and cerebrospinal fluid biomarkers of Alzheimer disease pathology in cognitively normal older individuals. Design, setting, and participants Cross-sectional cohort study at The Charles F. and Joanne Knight Alzheimer's Disease Research Center at Washington University in St Louis, St Louis, Missouri, among 207 older adults with normal cognition (Clinical Dementia Rating, 0). Main outcomes and measures Resting-state functional connectivity magnetic resonance imaging measures of default mode network integrity. Results Decreased cerebrospinal fluid Aβ42 and increased cerebrospinal fluid phosphorylated tau181 were independently associated with reduced default mode network integrity, with the most prominent decreases in functional connectivity observed between the posterior cingulate and medial temporal regions. Observed reductions in functional connectivity were unattributable to age or structural atrophy in the posterior cingulate and medial temporal areas. Similar resting-state functional connectivity magnetic resonance imaging findings in relation to cerebrospinal fluid biomarkers were obtained using region-of-interest analyses and voxelwise correlation mapping. Conclusions and relevance Both Aβ and tau pathology affect default mode network integrity before clinical onset of Alzheimer disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wang, L., Brier, M. R., Snyder, A. Z., Thomas, J. B., Fagan, A. M., Xiong, C., et al. (2013). Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity. JAMA neurology. https://doi.org/10.1001/jamaneurol.2013.3253
Vancouver
Wang L, Brier MR, Snyder AZ, Thomas JB, Fagan AM, Xiong C, et al. Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity. JAMA neurology. 2013. doi:10.1001/jamaneurol.2013.3253. PMID: 23959173.
BibTeX
@article{wang2013-23959173,
author = {Wang, L. and Brier, M. R. and Snyder, A. Z. and Thomas, J. B. and Fagan, A. M. and Xiong, C. and Benzinger, T. L. and Holtzman, D. M. and others},
title = {{Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity}},
journal = {JAMA neurology},
year = {2013},
doi = {10.1001/jamaneurol.2013.3253},
pmid = {23959173},
url = {https://doi.org/10.1001/jamaneurol.2013.3253}
}
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Key findings
- Results Decreased cerebrospinal fluid Aβ42 and increased cerebrospinal fluid phosphorylated tau181 were independently associated with reduced default mode network integrity, with the most prominent decreases in functional connectivity observed between the posterior cingulate and medial temporal regions.
Why it matters
In 207 cognitively normal older adults, lower spinal fluid amyloid and higher phosphorylated tau were each linked to reduced default mode network connectivity on brain scans. This is a cross-sectional association study and does not show that these brain changes cause dementia or that any treatment can reverse them.
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Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 51/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 88 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.9 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 3 / 6 | Cited 6.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Beau M. Ances: h-index 81 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23959173) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
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Read the original
- DOI: 10.1001/jamaneurol.2013.3253
- PubMed: 23959173
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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