Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,251–18,275 of 27,380 studies, newest first · page 731 of 1096.
December 2013 18
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2013-12-01
Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people
57/100 ✓ Peer-reviewed Hippocampus size on brain scans JAMA neurology
Key finding: Such findings challenge the proposed sequence and suggest that Aβ-independent precursors underlie AD-typical neurodegenerative patterns. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia
40/100 ✓ Peer-reviewed Hippocampus size on brain scans JAMA psychiatry
Key finding: Our findings support the theory that alterations in hippocampal glutamate levels potentially account for structural deficits in the hippocampus observed in schizophrenia neuroimaging studies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Memory loss in Alzheimer's disease
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Dialogues in clinical neuroscience
Key finding: The individual pattern of impaired memory functions correlates with parameters of structural or functional brain integrity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
The effects of poverty on childhood brain development: the mediating effect of caregiving and stressful life events
52/100 ✓ Peer-reviewed Hippocampus size on brain scans JAMA pediatrics
Key finding: Poverty was associated with smaller white and cortical gray matter and hippocampal and amygdala volumes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-12-01
Epidemiology of diabetes and diabetes complications in the elderly: an emerging public health burden
36/100 ✓ Peer-reviewed Clinical safety Current diabetes reports
Key finding: Persons with diabetes are living longer and are vulnerable to the traditional microvascular and macrovascular complications of diabetes but also at increased risk for geriatric syndromes.
Full summary, score breakdown and related studies → Original source
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2013-12-01
Biomarker Modeling of Alzheimer’s Disease
58/100 ✓ Peer-reviewed Biomarkers Neuron
Key finding: Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in therapeutic trials. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Life in Balance
26/100 ✓ Peer-reviewed Risk factors ASHA Leader
Key finding: The fall caused a sprained wrist and significant bruising to her hip, and although her scrapes and bruises healed, she was left with an overwhelming fear of falling again. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Neuronal clearance of amyloid-β by endocytic receptor LRP1
51/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Accumulation, aggregation, and deposition of amyloid-β (Aβ) peptides generated through proteolytic cleavage of amyloid precursor protein (APP) are likely initiating events in the pathogenesis of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model
48/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Genetic, cell biological, and biochemical studies suggest that reducing amyloid-β (Aβ) production may serve as a rational therapeutic avenue to delay or prevent AD progression. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Human iPSC-based modeling of late-onset disease via progerin-induced aging
53/100 ✓ Peer-reviewed Lewy body dementia Cell stem cell
Key finding: Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Unmet needs of community-residing persons with dementia and their informal caregivers: findings from the maximizing independence at home study
57/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: Many community-residing PWD and their caregivers have unmet dementia-related needs for care, services, and support. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Prevalence and impact of pain among older adults in the United States: findings from the 2011 National Health and Aging Trends Study
60/100 ✓ Peer-reviewed Caregiving Pain
Key finding: The overall prevalence of bothersome pain in the last month was 52.9%, afflicting 18.7 million older adults in the United States. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Hypertension, brain damage and cognitive decline
43/100 ✓ Peer-reviewed Prevention and risk Current hypertension reports
Key finding: Cognitive decline is rapidly becoming an important cause of disability worldwide and contributes significantly to increased mortality.
Full summary, score breakdown and related studies → Original source
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2013-12-01
Predicting Alzheimer disease with β-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing
57/100 ✓ Peer-reviewed Prevention and risk Annals of neurology
Key finding: Subtle memory impairment with a positive β-amyloid scan identifies healthy individuals at high risk for MCI or AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Long-term multivitamin supplementation and cognitive function in men: a randomized trial
69/100 ✓ Peer-reviewed Treatments Annals of internal medicine
Key finding: In male physicians aged 65 years or older, long-term use of a daily multivitamin did not provide cognitive benefits. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-12-01
Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases
39/100 ✓ Peer-reviewed Genetics Rejuvenation research
Key finding: Decline of cognition and increasing risk of neurodegenerative diseases are major problems associated with aging in humans. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-01
Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies
49/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology
Key finding: We found that total β-amyloid pathology scores correlated positively with total α-synuclein pathology scores (ρ = 0.692, p = 0.001).
Full summary, score breakdown and related studies → Original source
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2013-12-01
Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep
64/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: Better sleep consolidation attenuates the effect of APOE genotype on incident AD and development of neurofibrillary tangle pathology. +1 more finding
Full summary, score breakdown and related studies → Original source
November 2013 7
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2013-11-29
Cardiorenal metabolic syndrome and diabetic cognopathy
38/100 ✓ Peer-reviewed Risk factors Cardiorenal medicine
Key finding: We posit that DC develops due to a convergence of aging, genetic and lifestyle abnormalities (overnutrition and lack of exercise), which result in multiple injurious metabolic and immunologic toxicities such as dysfunctional immune responses, oxidative stress, inflammation, insulin resistance, and dysglycemia (systemically and in the brain). +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-11-28
Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers
50/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage. Clinical
Key finding: SPARE-AD and ADAS-Cog were found to have similar predictive value, and their combination was significantly better than their individual performance. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-11-27
Prospective flutemetamol positron emission tomography and histopathology in normal pressure hydrocephalus
50/100 ✓ Peer-reviewed Brain scans and imaging Neuro-degenerative diseases
Key finding: Four of the 17 patients (23.5%) had amyloid-β pathology based on the overall pathology read and also showed increased [(18)F]flutemetamol uptake. [(18)F]Flutemetamol standardized uptake values from the biopsy site were significantly associated with biopsy specimen amyloid-β levels (Pearson's r = 0.67; p = 0.006). +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-11-27
Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic
55/100 ✓ Peer-reviewed Lewy body dementia Cell reports
Key finding: Intranuclear neuronal RNA foci have been observed in ALS and FTD tissues, suggesting that G4C2 RNA may be toxic.
Full summary, score breakdown and related studies → Original source
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2013-11-26
The role of protein glycosylation in Alzheimer disease
43/100 ✓ Peer-reviewed Risk genes beyond APOE The FEBS journal
Key finding: This review serves to highlight the role of protein glycosylation in Alzheimer disease (AD), a topic that has not been thoroughly investigated, although glycosylation defects have been observed in AD patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-11-26
Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms
45/100 ✓ Peer-reviewed Risk factors Nutritional neuroscience
Key finding: It is well known that a poor diet and obesity can lead to certain disorders such as type II diabetes, metabolic syndrome, and heart disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-11-25
Fluid biomarkers for diagnosing dementia: rationale and the Canadian Consensus on Diagnosis and Treatment of Dementia recommendations for Canadian physicians
38/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy
Key finding: The role of fluid biomarkers in patient care is a rapidly evolving field. +3 more findings
Full summary, score breakdown and related studies → Original source
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