Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,126–18,150 of 27,380 studies, newest first · page 726 of 1096.
January 2014 25
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2014-01-07
Open questions for Alzheimer's disease immunotherapy
40/100 ✓ Peer-reviewed Drug development Alzheimer's research & therapy
Key finding: Despite disappointing results to date from anti-Aβ immunotherapy therapeutic trials, there is continued hope that such immunotherapies, especially if used in the preclinical stages, could prove to be the first disease-modifying therapies available for AD.
Full summary, score breakdown and related studies → Original source
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2014-01-07
The dual role of astrocyte activation and reactive gliosis
36/100 ✓ Peer-reviewed Brain scans and imaging Neuroscience letters
Key finding: Activation of astrocytes is associated with changes in the expression of many genes and characteristic morphological hallmarks, and has important functional consequences in situations such as stroke, trauma, epilepsy, Alzheimer's disease (AD), and other neurodegenerative diseases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-06
Predictors of cognitive impairment in an early stage Parkinson's disease cohort
66/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society
Key finding: Early prediction of future cognitive impairment would help target future interventions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-06
DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline
42/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neurochemistry
Key finding: DJ-1 mutations that result in gene deficiency are linked to increased risk of Parkinson's disease (PD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-06
Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations
48/100 ✓ Peer-reviewed Caregiving Frontiers in neurology
Key finding: The presence of microbleeds has been suggested to confer increased risk of incident intracerebral hemorrhage - particularly in the setting of anticoagulation - and of complications of immunotherapy for AD.
Full summary, score breakdown and related studies → Original source
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2014-01-04
Initiating palliative care consults for advanced dementia patients in the emergency department
45/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Preexisting physician attitudes, knowledge, and beliefs prevent emergency physicians from addressing PC needs for AD patients.
Full summary, score breakdown and related studies → Original source
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2014-01-04
Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers
54/100 ✓ Peer-reviewed Getting a diagnosis Biochemical pharmacology
Key finding: In the US alone, Alzheimer disease (AD) - the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain - causes estimated health-care costs of $ 172 billion per year. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-04
Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study
63/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: This study shows significant therapeutic effects of trazodone 50 mg in community-dwelling AD patients with SD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-03
Early life development in a multiethnic sample and the relation to late life cognition
49/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: These findings demonstrate that early life experiences influence the trajectory of cognitive aging. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-02
Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
40/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy
Key finding: The spectrum of sporadic frontotemporal lobar degeneration associated with tau pathology includes progressive supranuclear palsy, corticobasal degeneration, and Pick's disease.
Full summary, score breakdown and related studies → Original source
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2014-01-02
Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis
47/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: Some reports, mostly retrospective epidemiological studies, have observed a decreased prevalence of AD in patients taking the cholesterol lowering drugs, statins. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-02
Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders
50/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society
Key finding: These findings may help in the search of peripheral AS aggregates in vivo for the early diagnosis of PD.
Full summary, score breakdown and related studies → Original source
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2014-01-02
Effect of tai chi on cognitive performance in older adults: systematic review and meta-analysis
70/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society
Key finding: Tai Chi shows potential to enhance cognitive function in older adults, particularly in the realm of executive functioning and in individuals without significant impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-02
Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration
58/100 ✓ Peer-reviewed Biomarkers Annals of neurology
Key finding: CSF NfL is elevated in symptomatic FTD and correlates with disease severity.
Full summary, score breakdown and related studies → Original source
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2014 year only
Targeting synaptic dysfunction in Alzheimer's disease by administering a specific nutrient combination
38/100 ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer's disease : JAD
Key finding: Memory dysfunction is one key early manifestation in AD and is associated with synapse loss. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014 year only
Cardiovascular risk profile in women and dementia
38/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: To explore current evidence on the association between components of the cardiovascular risk profile and dementia risk in women and men, we reviewed all studies reporting the risk of dementia associated with cardiovascular risk factors stratified by gender and found 53 eligible articles out of over 4,000 published since the year 2000. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014 year only
[Sleep problems in dementia]
38/100 ✓ Peer-reviewed Risk factors Rinsho shinkeigaku = Clinical neurology
Key finding: Age related sleep disturbances and sleep disorders due to the neurodegeneration including REM sleep behavior disorder also increase in dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014 year only
Retinal microvasculature in Alzheimer's disease
38/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: Recent clinic- and population-based studies have demonstrated a link between retinal vascular changes and dementia, in particular AD, and cerebral small vessel disease.
Full summary, score breakdown and related studies → Original source
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2014 year only
A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman
43/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Alzheimer's disease : JAD
Key finding: Mutations in PSEN1 are the most common cause of autosomal dominant familial Alzheimer's disease (FAD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014 year only
PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach
38/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Alzheimer's disease : JAD
Key finding: PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients.
Full summary, score breakdown and related studies → Original source
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2014 year only
Computerized Neurocognitive Test (CNT) in mild cognitive impairment and Alzheimer's disease
38/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia & neuropsychologia
Key finding: Currently, computerized batteries are of great value in detecting cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014 year only
Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease
45/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD
Key finding: p-Tau181 levels were higher in the lvPPA-AD group than in the aMCI-AD group (p < 0.05). +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-01
Multivariate data analysis and machine learning in Alzheimer's disease with a focus on structural magnetic resonance imaging
40/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD
Key finding: In particular, these classifiers have been used to discriminate AD patients from healthy control subjects and to predict conversion from mild cognitive impairment to AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-01
Deep learning based imaging data completion for improved brain disease diagnosis
62/100 ✓ Peer-reviewed Digital health tools Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Key finding: Combining multi-modality brain data for disease diagnosis commonly leads to improved performance.
Full summary, score breakdown and related studies → Original source
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2014-01-01
Who knows, who cares? Dementia knowledge among nurses, care workers, and family members of people living with dementia
36/100 ✓ Peer-reviewed End-of-life care Journal of palliative care
Key finding: This paper reports the results of a study that assessed dementia knowledge among these two cohorts using the Dementia Knowledge Assessment Tool; the study surveyed 279 staff members and 164 family members of residents with dementia.
Full summary, score breakdown and related studies → Original source
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