Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,626–24,650 of 27,380 studies, newest first · page 986 of 1096.
January 2003 21
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2003-01-01
Neuropathologic changes in Alzheimer's disease
42/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of clinical psychiatry
Key finding: These include alterations in the function of the monoaminergic neural systems that release glutamate, norepinephrine, and serotonin as well as a few neuropeptide-containing systems. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
54/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of neuropsychiatry and clinical neurosciences
Key finding: The frequency of major depression decreased in severe stages, while agitation, aggression, and psychosis were more frequent in late stages. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Frequency and characteristics of anxiety among patients with Alzheimer's disease and related dementias
52/100 ✓ Peer-reviewed Cognitive tests and assessment The Journal of neuropsychiatry and clinical neurosciences
Key finding: The authors used the anxiety subscale of the Neuropsychiatric Inventory (NPI), an instrument with established reliability and validity, to compare patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
[Biological markers for Alzheimer disease]
30/100 ✓ Peer-reviewed Tau biomarkers Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
Key finding: Cerebrospinal fluid (CSF) is a useful source of diagnostic information. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development
41/100 ✓ Peer-reviewed Risk genes beyond APOE Neuromolecular medicine
Key finding: We now provide evidence that AD patients exhibit an enhanced immune response to Abeta and that, contrary to expectations, Abeta antibodies enhance the neurotoxic activity of the peptide. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease
40/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology
Key finding: Given these NRG-1 actions, we hypothesized that the synaptic loss, gliosis, inflammation, and neuronal death occurring in Alzheimer disease (AD) is associated with altered expression of NRG-1 and its receptors (the erbB2, erbB3, and erbB4 membrane tyrosine kinases). +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Age-dependent cognitive decline in the APP23 model precedes amyloid deposition
47/100 ✓ Peer-reviewed Risk genes beyond APOE The European journal of neuroscience
Key finding: A hidden-platform Morris-type water maze showed an age-dependent decline of spatial memory capacities in the APP23 model. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum
Key finding: Overexpression of genes located on chromosome 21, as a result of extra gene load, has been considered a central hypothesis for the explanation of the DS phenotype. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-01-01
Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's disease patients
54/100 ✓ Peer-reviewed Risk factors Behavioral sleep medicine
Key finding: Sleep in the nursing home environment is extremely fragmented, possibly in part as a result of decreased light exposure. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-01-01
Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management
42/100 ✓ Peer-reviewed Risk factors Drugs
Key finding: Management mainly consists of cumulative dose-reduction or lower dose-intensities, especially in patients who are at higher risk to develop neurotoxic side effects.
Full summary, score breakdown and related studies → Original source
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2003-01-01
Nursing home characteristics associated with tube feeding in advanced cognitive impairment
37/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: Assessment by a speech therapist, staffing ratios, advance directives, fiscal considerations, and specialized dementia units are potentially modifiable factors in nursing homes that may influence the practice of tube feeding in advanced cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Progressive nonfluent aphasia and subsequent aphasic dementia associated with atypical progressive supranuclear palsy pathology
40/100 ✓ Peer-reviewed Digital health tools European neurology
Key finding: Neuropathologic examination revealed findings characteristic of progressive supranuclear palsy (PSP) except that the cortical pathology was more widespread than is typical of PSP. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-01-01
Primary progressive aphasia: PPA and the language network
45/100 ✓ Peer-reviewed Digital health tools Annals of neurology
Key finding: PPA patients showed longer reaction times and reduced accuracy versus controls on the language tasks, but no performance differences on the control task. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-01-01
Delirium symptoms in post-acute care: prevalent, persistent, and associated with poor functional recovery
59/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: The data from this study provide strong preliminary evidence that, in patients newly admitted to post-acute care facilities from acute care hospitals, delirium symptoms are prevalent, persistent, and associated with poor functional recovery. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Poor outcome after first-ever stroke: predictors for death, dependency, and recurrent stroke within the first year
52/100 ✓ Peer-reviewed How common it is Stroke
Key finding: In addition to age and stroke severity, heart diseases and dementia before the stroke seem to have an impact on mortality and recurrence after 1 year. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-01-01
Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment
52/100 ✓ Peer-reviewed How common it is The Lancet. Neurology
Key finding: However, recent evidence also suggests that the aetiological heterogeneity among individuals with MCI could be greater than previously reported.
Full summary, score breakdown and related studies → Original source
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2003-01-01
Evaluation of dementia in the cardiovascular health cognition study
64/100 ✓ Peer-reviewed Disparities Neuroepidemiology
Key finding: The CHS has developed a methodology for longitudinal studies of dementia in large cohorts and represents the largest study of dementia including cognitive testing, MRI and genetic markers.
Full summary, score breakdown and related studies → Original source
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2003-01-01
Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia
63/100 ✓ Peer-reviewed Caregiving The Cochrane database of systematic reviews
Key finding: Memory problems are a defining feature of the early stages of Alzheimer's disease (AD) and vascular dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-01-01
Dementia with Lewy bodies
38/100 ✓ Peer-reviewed Brain scans and imaging Seminars in clinical neuropsychiatry
Key finding: More recently, alpha-synuclein antibodies have revealed extensive neuritic pathology in DLB demonstrating a neurobiological link with other "synucleinopathies" including PD and multiple system atrophy (MSA). +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Lecithin for dementia and cognitive impairment
69/100 ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews
Key finding: Alzheimer's disease sufferers have been found to have a lack of the enzyme responsible for converting choline into acetylcholine within the brain. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-01
Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial
65/100 ✓ Peer-reviewed Treatments Clinical therapeutics
Key finding: The mean (SD) age in the CA group was 72.2(7.5) years (range, 60-80 years), and in the placebo group it was 71.7 (7.4) years(range, 60-80 years). +2 more findings
Full summary, score breakdown and related studies → Original source
December 2002 4
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2002-12-28
Staging of brain pathology related to sporadic Parkinson’s disease
56/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Aging
Key finding: Lesions initially occur in the dorsal motor nucleus of the glossopharyngeal and vagal nerves and anterior olfactory nucleus. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-12-20
Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases
36/100 ✓ Peer-reviewed Drug development Expert Reviews in Molecular Medicine
Key finding: Lipid rafts are also preferential sites of formation for pathological forms of the prion protein (PrPSc) and of the [beta]-amyloid peptide associated with Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2002-12-18
Role of protein kinase B in Alzheimer's neurofibrillary pathology
46/100 ✓ Peer-reviewed Tau biomarkers Acta neuropathologica
Key finding: Activated GSK-3 has been previously shown to be preferentially associated with neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-12-07
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1)
42/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: We previously found that BACE1 also cleaved a membrane-bound sialyltransferase, ST6Gal I. +3 more findings
Full summary, score breakdown and related studies → Original source
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