Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,626–19,650 of 27,380 studies, newest first · page 786 of 1096.
February 2012 25
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2012-02-23
Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study
59/100 ✓ Peer-reviewed Health systems and care delivery BMJ (Clinical research ed.)
Key finding: Though these findings cannot prove causality, and we cannot rule out the possibility of residual confounding, they provide more evidence of the risk of using these drugs in older patients, reinforcing the concept that they should not be used in the absence of clear need. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-23
Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis
40/100 ✓ Peer-reviewed Drug development PloS one
Key finding: GLP-1 receptors are widely expressed in the brain and spinal cord, and our prior studies have shown that Ex-4 is neuroprotective in several neurodegenerative disease rodent models, including stroke, Parkinson's disease and Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-23
Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project
52/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: The reduced metabolic connections both in hypometabolic and nonhypometabolic areas in pAD patients suggest that metabolic disconnection (reflecting early diaschisis) may antedate remote hypometabolism (early sign of synaptic degeneration).
Full summary, score breakdown and related studies → Original source
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2012-02-22
Circulating IL-6 and CRP are associated with MRI findings in the elderly: the 3C-Dijon Study
60/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: IL-6, and, to a lesser degree, CRP levels were associated with WMH severity as well as global markers of brain atrophy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-22
CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease
53/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Measures of neuronal damage/dysfunction are likely good surrogates for disease progression in Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-22
Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients
46/100 ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry
Key finding: 10 years into PD, a significant proportion of patients developed dopa resistant motor and non-motor features. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-20
Performance on an Everyday Life Activity in Persons Diagnosed with Alcohol Dependency Compared to Healthy Controls: Relations between a Computerized Shopping Task and Cognitive and Clinical Variables†
31/100 ✓ Peer-reviewed Risk factors Alcohol and Alcoholism
Key finding: Performance on the shopping task significantly differentiated patients and healthy controls for several variables and, in particular, for total time. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-19
The adverse effects of air pollution on the nervous system
40/100 ✓ Peer-reviewed Risk factors Journal of toxicology
Key finding: Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. +3 more findings
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2012-02-19
Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models
47/100 ✓ Peer-reviewed Biomarkers Journal of neuroinflammation
Key finding: These results suggest that 4-O-methylhonokiol inhibits LPS-induced amyloidogenesis via anti-inflammatory mechanisms. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-17
Parkinson's disease, insulin resistance and novel agents of neuroprotection
47/100 ✓ Peer-reviewed Drug development Brain : a journal of neurology
Key finding: Furthermore, parallels are also emerging between these same pathways and neurodegeneration associated with Alzheimer's disease and Huntington's disease.
Full summary, score breakdown and related studies → Original source
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2012-02-15
PINK1- and Parkin-mediated mitophagy at a glance
40/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Cell Science
Key finding: Recently, work in cultured cells has shown that Parkin can mediate autophagy of damaged mitochondria (termed mitophagy) (Narendra et al., 2008) downstream of PINK1 (Geisler et al., 2010a; Matsuda et al., 2010; Narendra et al., 2010b; Vives-Bauza et al., 2010). +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-15
A human stem cell model of early Alzheimer's disease pathology in Down syndrome
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Science translational medicine
Key finding: We found that cortical neurons generated from iPS cells and embryonic stem cells from Down syndrome patients developed AD pathologies over months in culture, rather than years in vivo.
Full summary, score breakdown and related studies → Original source
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2012-02-15
Cognitive stimulation to improve cognitive functioning in people with dementia
75/100 ✓ Peer-reviewed Caregiving The Cochrane database of systematic reviews
Key finding: RO emphasised the engagement of nursing assistants in a hopeful, therapeutic process but became associated with a rigid, confrontational approach to people with dementia, leading to its use becoming less and less common. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-13
Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: Childhood maltreatment or abuse is a major risk factor for mood, anxiety, substance abuse, psychotic, and personality disorders, and it is associated with reduced adult hippocampal volume, particularly on the left side. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-13
Performance Characteristics of Amyloid PET with Florbetapir F 18 in Patients with Alzheimer's Disease and Cognitively Normal Subjects
47/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine
Florbetapir F 18 appears to have a wide effective dose range and a high test-retest reliability for both quantitative (SUVr) values and visual assessment of the ligand.
Full summary, score breakdown and related studies → Original source
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2012-02-13
Dementia prevention: current epidemiological evidence and future perspective
52/100 ✓ Peer-reviewed Prevention and risk Alzheimer's research & therapy
Key finding: Multidisciplinary research involving epidemiology, neuropathology, and neuroimaging has provided sufficient evidence that vascular risk factors significantly contribute to the expression and progression of cognitive decline (including dementia) but that active engagement in social, physical, and mentally stimulating activities may delay the onset of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-02-09
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
41/100 ✓ Peer-reviewed Genetics Science (New York, N.Y.)
Key finding: Alzheimer's disease (AD) is associated with impaired clearance of β-amyloid (Aβ) from the brain, a process normally facilitated by apolipoprotein E (apoE).
Full summary, score breakdown and related studies → Original source
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2012-02-09
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
48/100 ✓ Peer-reviewed Brain tissue and pathology Human molecular genetics
Key finding: We performed exome sequencing in five individuals from three ADCA-DN kindreds and identified DNMT1 as the only gene with mutations found in all five affected individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-09
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
48/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: These results support a previously uncharacterized role for TDP-43 in posttranscriptional regulation of miRNA expression in both the nucleus and the cytoplasm.
Full summary, score breakdown and related studies → Original source
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2012-02-09
Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: a prospective study
56/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society
Key finding: Four years after the initial evaluation, 48% with RBD developed dementia, compared to 0% of those without (P-adjusted = 0.014). +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-09
Clinical validation of 18F-AZD4694, an amyloid-β-specific PET radioligand
47/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Noninvasive quantitative approaches provide valid estimates of amyloid-β binding. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-02-07
Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: a 10/66 population-based study
66/100 ✓ Peer-reviewed Mild cognitive impairment PLoS medicine
Key finding: An algorithm-derived diagnosis of aMCI showed few sociodemographic associations but was consistently associated with higher disability and neuropsychiatric symptoms in addition to showing substantial variation in prevalence across LAMIC populations. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-07
Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms
43/100 ✓ Peer-reviewed Mild cognitive impairment Antioxidants & redox signaling
Key finding: Alzheimer's disease (AD) is the most common cause of dementia and a progressive neurodegeneration that appears to result from multiple pathogenic mechanisms (including protein misfolding/aggregation, involved in both amyloid β-dependent senile plaques and tau-dependent neurofibrillary tangles), metabolic and mitochondrial dysfunction, excitoxicity, calcium handling impairment, glial cell dysfunction, neuroinflammation, and oxidative stress. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-06
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis
50/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of immunology (Baltimore, Md. : 1950)
Key finding: Individuals with genetic mutations inactivating TREM2 or DAP12 develop the Nasu-Hakola disease (NHD) with cystic-like lesions of the bone and brain demyelination that lead to fractures and presenile dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-02-03
Concurrent impairments in sleep and memory in amnestic mild cognitive impairment
36/100 ✓ Peer-reviewed Risk factors Journal of the International Neuropsychological Society : JINS
Key finding: Furthermore, aMCI patients spent less time in slow-wave sleep and showed lower delta and theta power during sleep compared to controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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