Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,401–18,425 of 27,380 studies, newest first · page 737 of 1096.
September 2013 25
-
2013-09-21
miR128 up-regulation correlates with impaired amyloid β(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease
36/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of aging
Key finding: New evidence has shown that the lysosomal system might be a crossroad in which etiological factors in AD pathogenesis converge. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-20
Increased neurofilament light chain blood levels in neurodegenerative neurological diseases
66/100 ✓ Peer-reviewed Biomarkers PloS one
Key finding: We developed and validated a novel ECL based sandwich immunoassay for the NfL protein in serum (NfL(Umea47:3)); levels in ALS were more than 20-fold higher than in controls. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2013-09-20
Planning for tomorrow whilst living for today: the views of people with dementia and their families on advance care planning
43/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: Health and social care professionals can build on people's preferences for informal planning by exploring the assumptions underlying them, providing information about the possible illness trajectory and discussing the options of care available.
Full summary, score breakdown and related studies → Original source
-
2013-09-20
The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
52/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica
Key finding: We suggest that this, in itself, cannot be the cause of AD because demonstrating such toxicity requires micromolar concentrations of these Abeta forms, while their levels in brain are a million times lower in the picomolar range. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-19
The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology
36/100 ✓ Peer-reviewed Genetics Progress in retinal and eye research
Key finding: We found that the proteins corresponding to these 65 (candidate) POAG disease genes take part in as few as four common functional molecular networks. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-19
The touchscreen operant platform for testing learning and memory in rats and mice
50/100 ✓ Peer-reviewed Lewy body dementia Nature protocols
Key finding: An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive tests can be run in a manner very similar to touchscreen methods currently used to test human subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-18
Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders
36/100 ✓ Peer-reviewed Genetics American journal of neurodegenerative disease
Key finding: Recently, GWAS of complex diseases and traits have focused less on individual susceptibility variants and instead have emphasized the biological pathways and networks revealed by genetic associations. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-18
Prospective study of Dietary Approaches to Stop Hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging
47/100 ✓ Peer-reviewed Prevention trials The American journal of clinical nutrition
Key finding: Higher levels of accordance with both the DASH and Mediterranean dietary patterns were associated with consistently higher levels of cognitive function in elderly men and women over an 11-y period. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-18
Preclinical AD predicts decline in memory and executive functions in subjective complaints
57/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: We assessed whether preclinical Alzheimer disease (AD) based on CSF biomarkers at baseline predicts decline in cognitive functioning as measured by repeated neuropsychological tests for 4 cognitive domains in patients with subjective complaints. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-18
The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study
59/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Atrophy in FAD is observed early, both in areas commonly associated with sporadic Alzheimer disease and also in the putamen and thalamus, 2 regions associated with early amyloid deposition in FAD mutation carriers. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-16
Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis
75/100 ✓ Peer-reviewed Prevention and risk Annals of neurology
Key finding: Adherence to a Mediterranean diet may contribute to the prevention of a series of brain diseases; this may be of special value given the aging of Western societies. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-15
Does loneliness mediate the relation between social support and cognitive functioning in later life?
52/100 ✓ Peer-reviewed Cognitive tests and assessment Social science & medicine (1982)
Key finding: Moreover, little is known about the underlying mechanisms between social support and cognitive functioning. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-15
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons
55/100 ✓ Peer-reviewed Lewy body dementia Nature neuroscience
Key finding: We found that FUS, an RNA/DNA-binding protein that has been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, is important for the DNA damage response (DDR). +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-13
Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia
74/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging
Key finding: Also, rare recessive mutations have been associated with frontotemporal dementia (FTD). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-13
Reliability of two-dimensional and three-dimensional pseudo-continuous arterial spin labeling perfusion MRI in elderly populations: comparison with 15O-water positron emission tomography
54/100 ✓ Peer-reviewed Mild cognitive impairment Journal of magnetic resonance imaging : JMRI
Key finding: The 3D GRASE pCASL offers better repeatability than 2D EPI pCASL, thereby may provide a reliable imaging marker for the evaluation of disease progression and treatment effects in MCI and early AD subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-12
Multivariate classification of blood oxygen level-dependent FMRI data with diagnostic intention: a clinical perspective
51/100 ✓ Peer-reviewed Digital health tools AJNR. American journal of neuroradiology
Key finding: There has been a recent upsurge of reports about applications of pattern-recognition techniques from the field of machine learning to functional MR imaging data as a diagnostic tool for systemic brain disease or psychiatric disorders. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-12
Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks
54/100 ✓ Peer-reviewed How common it is Statistics in medicine
Key finding: In this work, we propose nonparametric inverse probability of censoring weighting estimators of the AUC corresponding to these two definitions, and we study their asymptotic properties. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-11
Tau immunotherapy and imaging
38/100 ✓ Peer-reviewed Drug development Neuro-degenerative diseases
Key finding: Over 12 years ago, we initiated a tau immunotherapy program, seeking to alleviate the functional impairments associated with tau lesions in tauopathies. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-11
A review of the effects of physical activity and exercise on cognitive and brain functions in older adults
50/100 ✓ Peer-reviewed Prevention trials Journal of aging research
Key finding: Studies supporting the notion that physical activity and exercise can help alleviate the negative impact of age on the body and the mind abound. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2013-09-11
Dementia care in eight European countries: developing a mapping system to explore systems
36/100 ✓ Peer-reviewed End-of-life care Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing
Key finding: The mapping system appears useful from a nurse manager's standpoint for exploring the dementia care pathway. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-11
7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: These results suggest that 7,8-DHF represents a novel oral bioactive therapeutic agent for treating AD.
Full summary, score breakdown and related studies → Original source
-
2013-09-10
Pain and the risk for falls in community-dwelling older adults: systematic review and meta-analysis
81/100 ✓ Peer-reviewed Clinical safety Archives of physical medicine and rehabilitation
Key finding: Community-dwelling older adults with pain were more likely to have fallen in the past 12 months and to fall again in the future. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2013-09-10
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease
52/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: Similar accumulations in mild cognitive impairment cases indicate that spliceosome changes occur in early stages of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2013-09-10
Midlife risk score for the prediction of dementia four decades later
67/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: A combination of modifiable vascular risk factors in midlife is highly predictive of the likelihood of dementia decades later.
Full summary, score breakdown and related studies → Original source
-
2013-09-09
Alteration of the microRNA network during the progression of Alzheimer's disease
50/100 ✓ Peer-reviewed Brain tissue and pathology EMBO Molecular Medicine
Key finding: Profiling of miRNAs in the prefrontal cortex of a second independent cohort of 49 patients grouped by Braak stages revealed 41 deregulated miRNAs.
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →