Newest studies

Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia

62/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: Graph theoretical analysis of the speech/language network showed that regions with shorter functional paths to the epicentre exhibited greater longitudinal atrophy. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Cerebral blood flow in small vessel disease: A systematic review and meta-analysis

73/100 ✓ Peer-reviewed Getting a diagnosis Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: Four longitudinal studies (n = 1079) gave differing results, e.g., more baseline white matter hyperintensity predated falling cerebral blood flow (3.9 years, n = 575); cerebral blood flow was low in regions that developed white matter hyperintensity (1.5 years, n = 40).

• Other Dementias

Full summary, score breakdown and related studies → Original source

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

40/100 ✓ Peer-reviewed Biomarkers Acta Neuropathologica Communications

Key finding: The pathogenic pathways leading to vascular cognitive impairment remain unclear but clinical and experimental data have shown that chronic reactive astrogliosis occurs within white matter lesions, indicating that a sustained pro-inflammatory environment affecting the white matter may contribute towards disease progression. +2 more findings

• Brain Biology
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

40/100 ✓ Peer-reviewed Clinical safety Frontiers in immunology

Key finding: Consequently, substantial evidence has accumulated over the past couple of decades that dysregulation of the KP and the production of neurotoxic metabolites are associated with many neuroinflammatory and neurodegenerative diseases, including Parkinson's disease, AIDS-related dementia, motor neurone disease, schizophrenia, Huntington's disease, and brain cancers.

• Brain Biology

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Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

51/100 ✓ Peer-reviewed Risk factors Physiological reviews

Key finding: Furthermore, we elaborate on the most prominent factors associated with brain insulin resistance, i.e., obesity, T2D, genes, maternal metabolism, normal aging, inflammation, and dementia, and on their roles regarding causes and consequences of brain insulin resistance.

• Risk Factors

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A co-design process developing heuristics for practitioners providing end of life care for people with dementia

40/100 ✓ Peer-reviewed End-of-life care BMC palliative care

Key finding: Four broad areas were identified as requiring complex decisions at the end of life; 1) eating/swallowing difficulties, 2) agitation/restlessness, 3) ending life-sustaining treatment, and 4) providing "routine care" at the end of life. +2 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Inflammasomes link vascular disease with neuroinflammation and brain disorders

36/100 ✓ Peer-reviewed Inflammation and the immune system Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: Inflammatory processes are associated with the aetiology and clinical progression of migraine, psychiatric conditions, epilepsy, cerebrovascular diseases, dementia and neurodegeneration, such as seen in Alzheimer's or Parkinson's disease. +2 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Dementia in the acute hospital: the prevalence and clinical outcomes of acutely unwell patients with dementia

49/100 ✓ Peer-reviewed Disparities QJM : monthly journal of the Association of Physicians

Key finding: A diagnosis of dementia confers an increased risk of either death or further admission within the following 12 months, highlighting the need for better cognitive screening in the acute setting, as well as targeted intervention such as comprehensive geriatric assessment. +2 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

The Empowering Role of Mobile Apps in Behavior Change Interventions: The Gray Matters Randomized Controlled Trial

63/100 ✓ Peer-reviewed Treatments JMIR mHealth and uHealth

Key finding: This paper explores the rationale for a mobile phone-led intervention and details the app's effect on behavior change and subsequent clinical outcomes. +4 more findings

• Clinical Trials
• Risk Factors
• Digital Tools

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[The Social Costs of Dementia in Japan: Focusing on the Informal Care Cost]

38/100 ✓ Peer-reviewed Caregiving Brain and nerve = Shinkei kenkyu no shinpo

Key finding: Due to the rapid increase of the number in people with dementia, social costs of dementia are also expected to rise. +2 more findings

• Caregiving
• Policy

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Identification of Physician-Diagnosed Alzheimer's Disease and Related Dementias in Population-Based Administrative Data: A Validation Study Using Family Physicians' Electronic Medical Records

50/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD

Key finding: Algorithms developed from health administrative data are sensitive and specific for identifying older adults with AD-RD.

• Caregiving

Full summary, score breakdown and related studies → Original source

Juvenile neuronal ceroid lipofuscinosis (Batten disease): current insights

40/100 ✓ Peer-reviewed Risk factors Degenerative neurological and neuromuscular disease

Key finding: Soon after diagnosis, patients begin to have slight ataxic symptoms, and at adolescence extrapyramidal symptoms (rigidity, bradykinesia, slow steps with flexion in hips and knees) occur with increasing frequency. +4 more findings

Full summary, score breakdown and related studies → Original source

[Current evidence on health benefits of the mediterranean diet]

52/100 ✓ Peer-reviewed Prevention trials Revista medica de Chile

Key finding: Several observational cross-sectional and prospective cohort studies show an association between this diet and a lower prevalence and incidence of chronic diseases, such as cardiovascular disease, cancer, metabolic syndrome, diabetes, and neurodegenerative diseases as well as a reduced overall mortality.

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts

38/100 ✓ Peer-reviewed TREM2 and immune genetics Clinical reviews in allergy & immunology

Key finding: Receptor activator for NF-κB ligand (RANKL or TNFSF11), a tumor necrosis factor (TNF) superfamily member, is the master cytokine required for osteoclastogenesis with essential co-stimulatory signals mediated by immunoreceptor tyrosine-based activation motif (ITAM)-signaling adaptors, DNAX-associated protein 12 kDa size (DAP12) and FcεRI gamma chain (FcRγ). +3 more findings

Full summary, score breakdown and related studies → Original source

How neuroinflammation contributes to neurodegeneration

58/100 ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)

Key finding: Accumulating evidence suggests that neurodegeneration occurs in part because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of Cerebral Microbleeds With Cognitive Decline and Dementia

62/100 ✓ Peer-reviewed How common it is JAMA neurology

Key finding: Microbleed prevalence was 15.3% (median [interquartile range] count, 1 [1-88]). +4 more findings

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Quality of End-of-Life Care Provided to Patients With Different Serious Illnesses

59/100 ✓ Peer-reviewed Getting a diagnosis JAMA internal medicine

Key finding: Among 57 753 decedents, approximately half of the patients with ESRD, cardiopulmonary failure, or frailty received palliative care consultations (adjusted proportions, 50.4%, 46.7%, and 43.7%, respectively) vs 73.5% of patients with cancer and 61.4% of patients with dementia (P Conclusions and relevance Family-reported quality of end-of-life care was significantly better for patients with cancer and those with dementia than for patients with ESRD, cardiopulmonary failure, or frailty, largely owing to higher rates of palliative care consultation and do-not-resuscitate orders and fewer deaths in the intensive care unit among patients with cancer and those with dementia. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Predicting imminent risk for fracture in patients aged 50 or older with osteoporosis using US claims data

53/100 ✓ Peer-reviewed Digital health tools Archives of osteoporosis

Key finding: In patients with osteoporosis and no recent fracture, falls, older age, poorer health status, comorbidities, and other potential fall risk factors were predictive of imminent risk for fracture. +2 more findings

Full summary, score breakdown and related studies → Original source

At-home tDCS of the left dorsolateral prefrontal cortex improves visual short-term memory in mild vascular dementia

72/100 ✓ Peer-reviewed Prevention trials Journal of the neurological sciences

Key finding: In patients with mild vascular dementia, anodal tDCS of the left DLPFC is able to produce additional effects to cognitive training on visual short-term memory, verbal working memory, and executive control. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Recent global trends in the prevalence and incidence of dementia, and survival with dementia

70/100 ✓ Peer-reviewed Prevention and risk Alzheimer's research & therapy

Key finding: We found no evidence to suggest that the current assumption of constant age-specific prevalence of dementia over time is ill-founded. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: However, recent evidence suggests that the accepted view of APP proteolysis by the canonical α-, β-, and γ-secretases is simplistic, with the discovery of a number of novel APP secretases (including δ- and η-secretases, alternative β-secretases) and additional metabolites, some of which may also cause synaptic dysfunction. +2 more findings

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Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial

60/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Trials

Key finding: Aβ40 levels changed less for the simvastatin group (not statistically significant). +3 more findings

• Clinical Trials
• Down Syndrome
• Prevention

Full summary, score breakdown and related studies → Original source

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

36/100 ✓ Peer-reviewed Drug development Cell reports

Key finding: We conclude that effector function is not required for efficacy, and effectorless tau antibodies may represent a safer approach to targeting tau.

• Brain Biology

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Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril

36/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

Key finding: Aβ(1-42) is the more neurotoxic species, aggregates much faster, and dominates in senile plaque of Alzheimer's disease (AD) patients. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Progress in physical activity over the Olympic quadrennium

57/100 ✓ Peer-reviewed Disparities Lancet (London, England)

Key finding: A finding specific to LMICs was that physical inactivity was higher in urban (vs rural) residents, which is a cause for concern because of the global trends toward urbanisation. +4 more findings

• Health Equity
• Lifestyle

Full summary, score breakdown and related studies → Original source