Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,001–19,025 of 27,380 studies, newest first · page 761 of 1096.
January 2013 13
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2013-01-01
Characterization of Mexican Americans with mild cognitive impairment and Alzheimer's disease
49/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD
Key finding: The findings showed that Mexican Americans (normal controls, MCI, and AD) were younger, less highly educated, performed more poorly on the MMSE, endorsed more symptoms of depression, were more likely to be diagnosed with diabetes, and possessed the ApoE ε4 allele less frequently. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Psychometric limitations of the mini-mental state examination among nondemented older adults: an evaluation of neurocognitive and magnetic resonance imaging correlates
49/100 ✓ Peer-reviewed Disparities Experimental aging research
Key finding: Overall, MMSE scores exhibited ceiling effects, poor test-retest reliability, limited sensitivity to subtle brain abnormalities, and a high rate of intrusion elsewhere in the neuropsychological battery. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
The global prevalence of dementia: a systematic review and metaanalysis
78/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The detailed estimates in this study constitute the best current basis for policymaking, planning, and allocation of health and welfare resources in dementia care. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-01
Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline
52/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer disease and associated disorders
Key finding: The site physician provided a provisional diagnosis, an estimate of their diagnostic confidence, and their plan for diagnostic evaluation and management both before and after receiving the results from amyloid imaging with florbetapir F18. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease
57/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: AD subjects had smaller ERC thickness and hippocampal and WBV volumes compared to MCI and NDC subjects. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project
44/100 ✓ Peer-reviewed Brain scans and imaging Journal of cognitive neuroscience
Key finding: These preliminary results show that above-average memory capacity can be encountered in advanced age.
Full summary, score breakdown and related studies → Original source
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2013-01-01
Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement
57/100 ✓ Peer-reviewed Getting a diagnosis JAMA neurology
Key finding: Our results show that TREM2 is responsible for an unexpectedly high number of dementia cases in our cohort, suggesting that this gene should be taken into account when mutations in other dementia genes are excluded. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
The worldwide economic impact of dementia 2010
54/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Worldwide costs of dementia are enormous and distributed inequitably.
Full summary, score breakdown and related studies → Original source
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2013-01-01
Midlife obesity and dementia: meta-analysis and adjusted forecast of dementia prevalence in the United States and China
63/100 ✓ Peer-reviewed Prevention and risk Obesity (Silver Spring, Md.)
Key finding: The past and ongoing increase in midlife obesity prevalence will contribute significantly to the future prevalence of dementia and public health measures to reduce midlife obesity are simultaneously primary prevention measures to reduce the risk of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-01
Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial
74/100 ✓ Peer-reviewed Prevention and risk The journal of nutrition, health & aging
Key finding: A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
[Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications]
43/100 ✓ Peer-reviewed Treatments Rinsho shinkeigaku = Clinical neurology
Key finding: Significantly increased levels of oxidized nucleic acids, proteins, and lipids have been described in the brains of subjects with Alzheimer disease (AD) and mild cognitive impairment (MCI) as well as young adults with Down syndrome, compared to age-matched controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-01
Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study
60/100 ✓ Peer-reviewed Treatments Clinical neuropharmacology
Key finding: A 2-hour infusion of 0.1 to 10 mg/kg ponezumab was well tolerated in subjects with mild-to-moderate AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association
55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Peer-reviewed, published literature was searched to ascertain available evidence relevant to these scenarios, and the AIT developed a consensus of expert opinion. +4 more findings
Full summary, score breakdown and related studies → Original source
December 2012 12
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2012-12-31
Molecular imaging of microglial activation in amyotrophic lateral sclerosis
47/100 ✓ Peer-reviewed Inflammation and the immune system PloS one
Key finding: Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain and may be a useful biomarker of inflammation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-28
The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain
36/100 ✓ Peer-reviewed Drug development European journal of pharmacology
Key finding: We have recently shown that analogues of the glucagon-like polypeptide 1 (GLP-1) such as liraglutide have potent neuroprotective properties in a mouse model of Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-26
Can MRI screen for CSF biomarkers in neurodegenerative disease?
45/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) may have overlapping clinical presentations despite distinct underlying neuropathologies, thus making in vivo diagnosis challenging. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-21
Rapid doubling of Alzheimer's amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution
40/100 ✓ Peer-reviewed Biomarkers F1000Research
Key finding: These effects on elevation of brain Aβ exceed those associated with trisomy 21, a known risk for early onset AD pathology, raising the possibility that clinical importance might be attached. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-21
Evaluation of chewing ability and its relationship with activities of daily living, depression, cognitive status and food intake in the community-dwelling elderly
42/100 ✓ Peer-reviewed Cognitive tests and assessment Geriatrics & gerontology international
Key finding: The aim of this study was to assess chewing ability using color-changeable chewing gum and to show the association between chewing ability and geriatric functions, as well as dietary status in the community-dwelling elderly. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-21
Engagement in social activities and progression from mild to severe cognitive impairment: the MYHAT study
57/100 ✓ Peer-reviewed Mild cognitive impairment International psychogeriatrics
Key finding: Alternatively, lesser engagement in social activities may be a marker of impending cognitive decline in MCI.
Full summary, score breakdown and related studies → Original source
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2012-12-21
Automated classification of primary progressive aphasia subtypes from narrative speech transcripts
36/100 ✓ Peer-reviewed Digital health tools Cortex; a journal devoted to the study of the nervous system and behavior
Key finding: Features that varied significantly between the groups were used to train machine learning classifiers, which were then tested on held-out data. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-12-21
Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging
53/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The findings support recent data indicating that the MoCA is superior to the MMSE as a global assessment tool, particularly in discerning earlier stages of cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-20
Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
41/100 ✓ Peer-reviewed Risk genes beyond APOE Neurochemistry international
Key finding: However, the effects of DFO on tau phosphorylation in the presence or absence of iron have yet to be determined. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-20
Alzheimer's Association recommendations for operationalizing the detection of cognitive impairment during the Medicare Annual Wellness Visit in a primary care setting
54/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The AWV requires an assessment to detect cognitive impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-19
In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI
48/100 ✓ Peer-reviewed Brain scans and imaging Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Key finding: The fluid attenuated inversion recovery, T(2), and T(1) weighted scans of these subjects were examined for possible cortical microinfarcts. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-12-19
Effect of study partner on the conduct of Alzheimer disease clinical trials
49/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Patients with nonspouse caregivers less frequently participate in AD dementia trials. +1 more finding
Full summary, score breakdown and related studies → Original source
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