Newest studies

Human hippocampal neurogenesis in adulthood, ageing and Alzheimer's disease

50/100 ✓ Peer-reviewed Genetics Nature

Key finding: Dysregulated neurogenesis was largely associated with changes in chromatin accessibility. +1 more finding

• Brain Biology

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Motor imagery-based neurofeedback in older adults: neural signatures and feasibility in a randomized controlled trial targeting age-related cognitive decline

42/100 ✓ Peer-reviewed Prevention trials Journal of NeuroEngineering and Rehabilitation

Key finding: Although a substantial proportion of TG participants achieved high MI accuracy values, statistical analyses revealed no cognitive improvements specific to TG, suggesting limited efficacy of the MI-based protocol compared to classical cognitive stimulation. +4 more findings

• Clinical Trials

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Risk of a Dementia Diagnosis in Community-Dwelling Older Adults With Normal MMSE Scores in the United States

44/100 ✓ Peer-reviewed Cognitive tests and assessment American Journal of Medicine Open

Key finding: • Lower MMSE scores—even by a single point—were independently associated with a significantly higher risk of developing ADRD. • Individuals with MMSE scores between 27 and 30 should not be viewed as a uniform group. • Further studies are needed to find ways to prevent ADRD in people who are at risk but do not yet show symptoms. +4 more findings

• Diagnosis

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From Institutions to Care Homes - A Case Study of Residentialization in Danish Profile Nursing Homes -

32/100 ✓ Peer-reviewed Health systems and care delivery Journal of the Korean housing association

Key finding: This study aims to analyze the spatial planning and operational strategies of three profile nursing homes in Copenhagen, Denmark-Hørgården, Peder Lykke Center, and Ørestad Plejecenter-and to derive design and operational implications for the development of Korean unit-based long-term care facilities

• Care Services

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Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment and Early Alzheimer Disease: Protocol for an Exploratory Double-Blind, Randomized, Placebo-Controlled Trial

52/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: Bacopa consumption is known to enhance cognitive performance in healthy individuals and is associated with alterations in pathways related to branched-chain and aromatic amino acid biosynthesis. +2 more findings

• Clinical Trials

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Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model

45/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of clinical investigation

Key finding: Mild traumatic brain injury (mTBI) from a closed-head injury (CHI) can lead to prevalent neuropsychiatric disorders, including mood disorders and an increased risk for neurodegenerative diseases and dementia. +3 more findings

• Brain Biology
• Risk Factors
• Early Stage

Full summary, score breakdown and related studies → Original source

Plasma p-tau217 for Alzheimer's disease diagnosis: a memory clinic implementation approach

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Among 163 patients (mean age 69.3 ± 7.4 years, 52% female), plasma p-tau217 distinguished A+ from A- individuals (area under the curve [AUC] 0.90, 81% sensitivity, 91% specificity). +3 more findings

• Biomarkers
• Diagnosis

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Consultation complexity and professionals consulted: a retrospective cohort study in English primary care

48/100 ✓ Peer-reviewed Health systems and care delivery The British journal of general practice : the journal of the Royal College of General Practitioners

Key finding: To examine changes in workload complexity associated with ARRS implementation.

• Care Services

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Long-term effect of discontinuing anticholinesterase treatment on cognitive decline and mortality in Alzheimer's disease in France: a quasi-experiment and target trial emulation study

40/100 ✓ Peer-reviewed Health systems and care delivery The Lancet regional health. Europe

Key finding: No significant difference in mortality (RR 1·10, 95% CI [0·95-1·29]) was observed over a five-year period. +2 more findings

• Treatments
• Clinical Trials
• Policy

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Evaluation of Memory Changes in Patient with Down Syndrome

26/100 ✓ Peer-reviewed Down syndrome and Alzheimer's SteadFAST Case Reports in PA Studies

Key finding: As chromosome 21 carries the amyloid precursor protein (APP) gene, this puts patients with Down syndrome at a significantly higher risk of developing Alzheimer disease.

• Down Syndrome
• Diagnosis

Full summary, score breakdown and related studies → Original source

Co-Developing a Culturally Tailored Dietary Intervention for ADRD Risk Reduction Using a Community-Based Research Approach: The MIND+SOUL Program

32/100 ✓ Peer-reviewed Risk factors Journal of Participatory Research Methods

Key finding: Alzheimer’s disease and related dementias (ADRD) disproportionately impact older Black American adults, with diet-related cardiometabolic conditions contributing to increased risk.

• Lifestyle
• Prevention

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Multimodal latent composites are associated with cognition and Alzheimer’s disease dementia: a framework for systems-level brain health

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Compared to the CN group, both MCI (β=−1.25, SE=0.19, p <.001) and AD dementia (β=−1.52, SE=0.16, p <.001) participants had lower Brain & Vascular Health composite scores. +2 more findings

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Natural compounds as multitarget agents in Alzheimer's diseases: evidence from in vivo and in vitro models

59/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in pharmacology

Key finding: Overall, the available evidence suggests that natural compounds confer multitarget neuroprotective effects that directly engage with key pathological mechanisms underlying AD. +3 more findings

• Brain Biology
• Treatments

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Clinical meaningfulness of anti-amyloid therapies in early Alzheimer's disease: Perspectives from the East and Southeast Asia region

38/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Anti-amyloid therapies (AATs) have demonstrated statistically significant slowing of disease progression at the group level in pivotal trials in early symptomatic AD. +1 more finding

• Treatments

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Presenting complaints and emergency triage priority of older adults hospitalized with delirium: a retrospective cohort study

53/100 ✓ Peer-reviewed Clinical safety BMC Geriatrics

Key finding: Among 2889 patients with delirium (mean age 85 years; 54.7% female), 59.8% were triaged at SETS 1–2 (high priority) and 40.2% at SETS 3–4 (low priority). +4 more findings

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Mediation of the relationship between air pollution and dementia: A UK Biobank study

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Exposure to the highest quintile of PM 2·5 (Rte:1·14, 95% CI:1·06-1·23), NO x (Rte:1·11, 95% CI:1·03-1·20) or NO 2 (Rte:1·08, 95% CI:0·99-1·16), compared to the lowest quintile, was associated with higher dementia risk. +1 more finding

• Risk Factors

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease

64/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Carriers had lower LAS-FNAME performance (P < 0.001) and higher p-tau217 (P < 0.001), NfL (P = 0.013), and GFAP (P < 0.001) levels than non-carriers. +3 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Quality of Medicare Skilled Home Health for People Living With Dementia in the US : National Patterns and Implications

37/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: We found significant county-level variability in utilization of high-quality home health. +4 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Co-designing a framework to communicate patient-centred outcomes in palliative care: involving patients and the public to reframe understanding

47/100 ✓ Peer-reviewed End-of-life care Journal of Patient-Reported Outcomes

Key finding: Eighteen members of the public-including patients, carers, and individuals with lived experience of both roles-along with two local board members and one representative from a statutory health and social care body, participated and were actively involved in developing the framework and co-producing outputs through structured small-group discussions. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Alzheimer’s related dementia severity classification from magnetic resonance imaging using derivative-free optimization of convolutional neural network

43/100 ✓ Peer-reviewed Getting a diagnosis Scientific Reports

Key finding: Compared to a baseline CNN and contemporary architectures, DAPA-CNN reduces the number of parameters by 85.6%, processing time by 42.8%, and memory usage by 76.6%, making it suitable for resource-constrained clinical environments.

• Brain Scans
• Digital Tools

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Enhanced diagnostic interpretation of the MoCA using machine learning

46/100 ✓ Peer-reviewed Digital health tools Frontiers in Neuroscience

Key finding: Machine learning models consistently outperformed conventional approach. +4 more findings

• Diagnosis
• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source

Down Syndrome

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's StatPearls Publishing, Treasure Island (FL)

Key finding: Although life expectancy has improved significantly in recent decades, individuals with Down syndrome experience unique health needs throughout their lifespan, including heightened risks of heart disease if congenital heart defects are present, hematologic disorders, autoimmune diseases, sleep-disordered breathing, sensory impairments, and neurological conditions such as early-onset Alzheimer disease.

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals

61/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's research & therapy

Key finding: ABI3S209F was significantly associated with increased risk of AD (OR = 1.22, p = 0.0012) and neurodegenerative disorders (OR = 1.21, p = 0.00023), but not with dementia (OR = 1.10, p = 0.06). +4 more findings

• Genetics
• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Berry Consumption and Its Role in the Modulation of Obesity and Mild Cognitive Impairment

53/100 ✓ Peer-reviewed Mild cognitive impairment Nutrients

Key finding: Most dementias are preceded by mild cognitive impairment (MCI), a transitional clinical stage characterized by cognitive decline that does not yet significantly interfere with activities of daily living. +4 more findings

• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Dementia Family Caregivers’ Involvement and Perceived Challenges in Health Care Interactions: Informing the GUIDE Model

52/100 ✓ Peer-reviewed Caregiving Journal of General Internal Medicine

Key finding: Most (92.5%) caregivers performed at least one health care interaction task. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source