Newest studies

Alzheimer’s Disease: From Pathogenesis to Emerging Therapeutic Targets

37/100 ✓ Peer-reviewed Disease mechanisms Journal of Clinical Medicine

Key finding: In particular, accumulating evidence highlights lysosomes as critical sites of intracellular Aβ toxicity. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials

72/100 ✓ Peer-reviewed Cognitive tests and assessment The Lancet

Key finding: Between May 18, 2021, and Sept 8, 2023, 9981 participants were screened, of whom 3808 were randomly assigned; 1855 in evoke (semaglutide, n=928; placebo, n=927) and 1953 in evoke+ (semaglutide, n=976; placebo, n=977). +4 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

The Role of Magnetic Resonance Spectroscopy ( MRS ), Diffusion‐Tensor‐Imaging ( DTI ) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

37/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Magnetic Resonance Imaging

Key finding: Consequently, great emphasis is placed on prevention and the development of early diagnosis techniques, which can lead to timely treatment and the prevention of the consequences of full-blown disease. +4 more findings

• Brain Scans
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Meat Consumption and Cognitive Health by APOE Genotype

59/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: Among 2157 older adults without dementia (mean [SD] age 71.2 [9.2] years; 1337 female [62.0%]), 1680 participants had longitudinal cognition data and 569 participants (26.4%) had APOE34/44 genotypes. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Hearing Loss as a Modifiable Risk Factor for Dementia

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: These findings indicate that severe survey-reported HL and SNHL are strongly associated with dementia.

• Risk Factors

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Association between Plasma P-tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease

71/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: Neuropathology cases included 46 Parkinson's disease and 10 dementia with Lewy bodies, and clinical cases included 173 Parkinson's disease, and 64 controls. +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Type 1 Diabetes and Incident Dementia

64/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Among 283,772 participants (mean [SD] age 64.62 [8.96] years; 56.7% women), 60.3% identified as non-Hispanic White and 13.3% as Hispanic/Latino. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer's disease using the Lumipulse platform

43/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

Key finding: Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). +3 more findings

• Biomarkers
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Annual Wellness Visits and Timing of Advance Care Planning Among Medicare Beneficiaries With Cognitive Impairment

53/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Among 118,174 beneficiaries who received an AWV, 27.62% initiated ACP within 4 years compared with 17.46% of nonrecipients (HR, 1.86; 95% CI, 1.84-1.89). +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Prediction and risk evaluation of delirium after surgery in older patients: development and internal validation of an algorithm from the prospective BioCog cohort study

62/100 ✓ Peer-reviewed Clinical safety British Journal of Anaesthesia

Key finding: Out of 929 patients, 184 (20%) experienced POD. +4 more findings

Full summary, score breakdown and related studies → Original source

Disturbing dreams and dementia incidence across diverse cohort studies: A COSMIC collaboration study

62/100 ✓ Peer-reviewed Genetics Psychiatry and Clinical Neurosciences

Key finding: Disturbing dreams were reported by 24.2% overall and all-cause dementia, and AD incidence was 10.8 and 5.3 per 1000 person-years, respectively. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Contingency of Plasma Dementia Biomarkers on Cognitive Profiles for Prognosis of Incident Dementia: The ARIC Study

43/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Plasma biomarkers such as phospho-tau species are increasingly used in clinical practice for the diagnosis of Alzheimer disease (AD). +3 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Loss of Proteostasis and Abnormal Aging in Down Syndrome: From Mechanisms to Interventions

39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Antioxidants (Basel, Switzerland)

Key finding: Beyond gene-dosage imbalance, trisomy 21 induces widespread transcriptional, metabolic, and proteomic remodeling that establishes a chronic state of proteotoxic and oxidative stress from early development. +3 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Coffee and Tea Intake, Dementia Risk, and Cognitive Function

73/100 ✓ Peer-reviewed Prevention and risk JAMA

Key finding: Greater consumption of caffeinated coffee and tea was associated with lower risk of dementia and modestly better cognitive function, with the most pronounced association at moderate intake levels. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Pharmacotherapy for Depression in Long-Term Care: A Real-World EHR Study

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery medRxiv

Key finding: Overall, 81.7% of residents diagnosed with depression had ≥1 pharmacological depression treatment order. +4 more findings

• Care Services
• Health Equity

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The Efficacy of Cognitive Training Programs in Slowing Cognitive Decline in Alzheimer's Patients

28/100 ✓ Peer-reviewed Prevention trials University of Michigan Undergraduate Research Journal

Key finding: Alzheimer's Disease (AD) is a progressive neurodegenerative condition that gradually impairs cognitive abilities such as memory, attention, and problem-solving, leading to significant challenges in everyday functioning and a decline in quality of life.

• Treatments
• Lifestyle

Full summary, score breakdown and related studies → Original source

Effects of aerobic exercise and computer-based cognitive training on cognition, functional independence, quality of life, and salivary cortisol levels in older adults with mild cognitive impairment: a randomized trial

56/100 ✓ Peer-reviewed Prevention trials Frontiers in Aging Neuroscience

Key finding: Combining aerobic exercise with cognitive training improves clinical outcomes in older adults with MCI and may influence stress-related neurobiological pathways. +4 more findings

• Clinical Trials
• Lifestyle
• Early Stage

Full summary, score breakdown and related studies → Original source

Cost-effectiveness of traditional and novel neurotherapeutic agents for Alzheimer's disease: A systematic review

49/100 ✓ Peer-reviewed Costs and economics Journal of Alzheimer's Disease

Key finding: Quality-adjusted life year (QALY) was the most common effectiveness measure (91%). +4 more findings

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Navigating Dementia Services: An International Review of Informal Caregiver Perspectives

45/100 ✓ Peer-reviewed Caregiving Dementia (London, England)

Key finding: This review underscores significant shortcomings in current dementia service delivery, particularly in coordination, communication, and inclusivity.

• Caregiving

Full summary, score breakdown and related studies → Original source

Family caregiver perspectives on administering home-based stimulation in patients with mild cognitive impairment

33/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: Quantitative ratings assessed caregivers' confidence, burden, and perceived benefits. +1 more finding

• Early Stage
• Caregiving
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Gait and movement analysis for discrimination between people with dementia and healthy control persons based on pose estimation and machine learning

43/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer s Disease

Key finding: In the TUGdt, participants performed the TUG test while simultaneously completing an additional cognitive task (i.e., animal naming (TUGdt-NA) or reciting months in reverse order (TUGdt-MB)).ResultsThe results showed that dual-task classification outperformed the single-task.

• Digital Tools

Full summary, score breakdown and related studies → Original source

Circulating Biomarkers of Neurodegeneration and All-Cause and Dementia-Specific Mortality

80/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: A total of 917 participants had a mean baseline age of 67.4 years (SD 12.1), 49.4% were female, and 48.6% self-identified as Black. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Efficacy of Dang Gui Shao Yao San in treating vascular dementia in animal models: a systematic review and meta-analysis

48/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

Key finding: Animal studies indicate that Dang Gui Shao Yao San (DGSYS) may enhance cognitive function in VaD models through mechanisms such as antioxidation and the enhancement of cerebral blood flow. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Advance Care Planning Intention and Associated Factors Among People With Dementia: A Mixed‐Methods Study

32/100 ✓ Peer-reviewed End-of-life care Journal of Advanced Nursing

Key finding: The overall advance care planning behavioural intention was at a moderately high level. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Estimating cognitive function score from mild cognitive impairment to moderate dementia using a hybrid model combining plasma biomarkers with electroencephalogram signal

39/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease

Key finding: Integrating EEG features with plasma biomarkers improves prediction of cognitive function from mild cognitive impairment to moderate dementia, pending external validation.

• Biomarkers
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source