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Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease
Christopher Gonzalez Corona, Paula Ospina Lopera, Meredith C Rowe, Clara Vila-Castelar, Averi Giudicessi, Vincent Malotaux, Bing He, Catarina Tristão-Pereira et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2026-02-22
Topic: Plasma and spinal-fluid biomarkers
Carriers had lower LAS-FNAME performance (P < 0.001) and higher p-tau217 (P < 0.001), NfL (P = 0.013), and GFAP (P < 0.001) levels than non-carriers. Higher p-tau217, NfL, and GFAP were associated with worse LAS-FNAME performance, controlling for age, sex, and education. The web-based LAS-FNAME is a promising tool for detecting early memory decline in AD, warranting future studies to evaluate its longitudinal utility. HIGHLIGHTS: The web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME) detects memory decline in presenilin 1 (PSEN1) mutation carriers.LAS-FNAME scores correlate with blood biomarkers in PSEN1 carriers.The web-based format enables remote assessment via participants' personal devices.The study was conducted in Spanish-speaking adults at risk for dementia.Findings support combined use of digital cognitive tools and blood biomarkers.
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APA 7th
Corona, C. G., Lopera, P. O., Rowe, M. C., Vila-Castelar, C., Giudicessi, A., Malotaux, V., et al. (2026). Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.70289
Vancouver
Corona CG, Lopera PO, Rowe MC, Vila-Castelar C, Giudicessi A, Malotaux V, et al. Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). 2026. doi:10.1002/dad2.70289. PMID: 41737720.
BibTeX
@article{corona2026-41737720,
author = {Corona, Christopher Gonzalez and Lopera, Paula Ospina and Rowe, Meredith C and Vila-Castelar, Clara and Giudicessi, Averi and Malotaux, Vincent and He, Bing and Tristão-Pereira, Catarina and others},
title = {{Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2026},
doi = {10.1002/dad2.70289},
pmid = {41737720},
url = {https://doi.org/10.1002/dad2.70289}
}
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Key findings
- Carriers had lower LAS-FNAME performance (P < 0.001) and higher p-tau217 (P < 0.001), NfL (P = 0.013), and GFAP (P < 0.001) levels than non-carriers.
- Higher p-tau217, NfL, and GFAP were associated with worse LAS-FNAME performance, controlling for age, sex, and education.
- The web-based LAS-FNAME is a promising tool for detecting early memory decline in AD, warranting future studies to evaluate its longitudinal utility.
- HIGHLIGHTS: The web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME) detects memory decline in presenilin 1 (PSEN1) mutation carriers.LAS-FNAME scores correlate with blood biomarkers in PSEN1 carriers.The web-based format enables remote assessment via participants' personal devices.The study was conducted in Spanish-speaking adults at risk for dementia.Findings support combined use of digital cognitive tools and blood biomarkers.
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 64/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41737720) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 36 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
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